Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Radiopharmaceuticals based on neurokinin-1 receptor antagonists for the diagnosis and therapy of a brain tumour - glioblastoma multiforme.

2017/25/B/NZ7/01896

Keywords:

glioblastoma multiforme aprepitant radiopharmaceuticals NK-1 rceptor NK1 receptor antagonists

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_16:
  • ST4_16: Ionic liquids

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Aleksandra Misicka-Kęsik 

Number of co-investigators in the project: 9

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 961 230 PLN

Project start date (Y-m-d): 2018-02-15

Project end date (Y-m-d): 2022-02-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Nowoczesny komputer z akcesoriami (13 000 PLN)
  2. Pompa strzykawka ze sterownikiem.
  3. Urządzenie filtracyjne do płytek 96-dołkowych z oprzyrządowaniem (76 000 PLN)
  4. Wirnik (rotor) do wirówki (8 000 PLN)
  5. Stacja wodna (10 776 PLN)
  6. Suchy blok grzejny (termoblok) (6 000 PLN)
  7. Wirówka laboratoryjna z wymiennymi rotorami (30 000 PLN)
  8. Homogenizator (6 000 PLN)
  9. Mikrowirówka.
  10. Zbiornik na ciekły azot (Dewar).
  11. Myjka ultradźwiękowa (3 600 PLN)
  12. Vortex z akcesoriami (3 400 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
    Authors:
    Halik, P.; Koźmiński, P.; Matalińska, J.; Lipiński, P.F.J.; Misicka, A.; Gniazdowska, E.
    Academic press:
    Pharmaceutics (rok: 2022, tom: 14, strony: 607), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics14030607 - link to the publication
  2. Application of Neurokinin-1 Receptor in Targeted Strategies for Glioma Treatment. Part I: Synthesis and Evaluation of Substance P Fragments Labeled with 99mTc and 177Lu as Potential Receptor Radiopharmaceuticals
    Authors:
    Agnieszka Majkowska-Pilip, Przemysław Koźmiński, Anna Wawrzynowska, Tadeusz Budlewski, Bogusław Kostkiewicz, Ewa Gniazdowska
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 2542), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23102542 - link to the publication
  3. Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure–Activity Relationships
    Authors:
    Joanna Matalińska, Katarzyna Kosińska, Paweł K. Halik, Przemysław Koźmiński, Piotr F. J. Lipiński, Ewa Gniazdowska, Aleksandra Misicka
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1214), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031214 - link to the publication
  4. Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors
    Authors:
    Halik, P. K.; Lipiński, P.F.J.; Matalińska, J.; Koźmiński, P.; Misicka, A.; Gniazdowska E.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3756), Wydawca: MDPI
    Status:
    Accepted for publication
    DOI:
    10.3390/molecules25163 - link to the publication
  5. The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
    Authors:
    Agnieszka Majkowska-Pilip, Paweł Krzysztof Halik, Ewa Gniazdowska
    Academic press:
    Pharmaceutics (rok: 2019, tom: 11, strony: 443), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics11090443 - link to the publication

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