Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Radiopharmaceuticals based on neurokinin-1 receptor antagonists for the diagnosis and therapy of a brain tumour - glioblastoma multiforme.

2017/25/B/NZ7/01896

Keywords:

glioblastoma multiforme aprepitant radiopharmaceuticals NK-1 rceptor NK1 receptor antagonists

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_16:
  • ST4_16: Ionic liquids

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Aleksandra Misicka-Kęsik 

Number of co-investigators in the project: 9

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 961 230 PLN

Project start date (Y-m-d): 2018-02-15

Project end date (Y-m-d): 2022-02-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Nowoczesny komputer z akcesoriami (13 000 PLN)
  2. Vortex z akcesoriami (3 400 PLN)
  3. Wirnik (rotor) do wirówki (8 000 PLN)
  4. Zbiornik na ciekły azot (Dewar).
  5. Homogenizator (6 000 PLN)
  6. Stacja wodna (10 776 PLN)
  7. Suchy blok grzejny (termoblok) (6 000 PLN)
  8. Myjka ultradźwiękowa (3 600 PLN)
  9. Urządzenie filtracyjne do płytek 96-dołkowych z oprzyrządowaniem (76 000 PLN)
  10. Mikrowirówka.
  11. Pompa strzykawka ze sterownikiem.
  12. Wirówka laboratoryjna z wymiennymi rotorami (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
    Authors:
    Halik, P.; Koźmiński, P.; Matalińska, J.; Lipiński, P.F.J.; Misicka, A.; Gniazdowska, E.
    Academic press:
    Pharmaceutics (rok: 2022, tom: 14, strony: 607), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics14030607 - link to the publication
  2. Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure–Activity Relationships
    Authors:
    Joanna Matalińska, Katarzyna Kosińska, Paweł K. Halik, Przemysław Koźmiński, Piotr F. J. Lipiński, Ewa Gniazdowska, Aleksandra Misicka
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1214), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031214 - link to the publication
  3. Application of Neurokinin-1 Receptor in Targeted Strategies for Glioma Treatment. Part I: Synthesis and Evaluation of Substance P Fragments Labeled with 99mTc and 177Lu as Potential Receptor Radiopharmaceuticals
    Authors:
    Agnieszka Majkowska-Pilip, Przemysław Koźmiński, Anna Wawrzynowska, Tadeusz Budlewski, Bogusław Kostkiewicz, Ewa Gniazdowska
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 2542), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23102542 - link to the publication
  4. The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
    Authors:
    Agnieszka Majkowska-Pilip, Paweł Krzysztof Halik, Ewa Gniazdowska
    Academic press:
    Pharmaceutics (rok: 2019, tom: 11, strony: 443), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics11090443 - link to the publication
  5. Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors
    Authors:
    Halik, P. K.; Lipiński, P.F.J.; Matalińska, J.; Koźmiński, P.; Misicka, A.; Gniazdowska E.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3756), Wydawca: MDPI
    Status:
    Accepted for publication
    DOI:
    10.3390/molecules25163 - link to the publication

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