Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Structural and functional analysis of immune checkpoints

2017/25/B/NZ1/00827

Keywords:

immune checkpoints immune system regulation signal transduction

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_4: Structural biology
  • NZ3_1: Cell biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Dubin 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 923 600 PLN

Project start date (Y-m-d): 2018-01-26

Project end date (Y-m-d): 2022-09-25

Project duration:: 56 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator do hodowli komórek (35 000 PLN)
  2. Dysk zewnętrzny 2 szt..

Information in the final report

  • Publication in academic press/journals (5)
  1. Macrocyclic Peptide Inhibitor of PD‐1/PD‐L1 Immune Checkpoint
    Authors:
    Magiera‐Mularz, K., Kuska, K., Skalniak, L., Grudnik, P., Musielak, B., Plewka, J., Kocik, J., Stec, M., Weglarczyk, K., Sala, D., Wladyka, B., Siedlar, M., Holak, T.A., Dubin, G.
    Academic press:
    Advanced Therapeutics (rok: 2021, tom: 4:(2), strony: 2000195 (1-6)), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/adtp.202000195 - link to the publication
  2. Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis
    Authors:
    Zyla, E., Musielak, B., Holak, T.A., Dubin, G.
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 4848), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26164848 - link to the publication
  3. Ultrasensitive electrochemical determination of the cancer biomarker protein sPD-L1 based on a BMS-8-modified gold electrode
    Authors:
    Niedziałkowski, P., Bojko, M., Ryl, J., Wcisło, A., Spodzieja, M., Magiera-Mularz, K., Guzik, K., Dubin, G., Holak, T., Ossowski, T., Rodziewicz-Motowidło, S.
    Academic press:
    Bioelectrochemistry (rok: 2021, tom: 139, strony: 107742), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2021.107742 - link to the publication
  4. Development of selective ssDNA micro-probe for PD-1 detection as a novel strategy for cancer imaging
    Authors:
    Malicki, S., Czarna, A., Zyla, E., Pucelnik, B., Galan, W., Chruscicka, B., Kaminska, M., Sochaj-Gregorczyk, A., Magiera-Mularz, K., Zieba, B., Wang, J., Benedyk-Machaczka, M., Koziel, J., Dubin, G., Mydel, P.
    Academic press:
    Scientific Reports (rok: 2023, tom: nd, strony: nd), Wydawca: Nature Portfolio
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe
    Authors:
    Malicki, S., Pucelik, B., Zyla, E., Benedyk-Machaczka, M., Galan, W., Golda A., Sochaj-Gregorczyk, A., Kaminska, M., Encarnacao, J.C., Chruscicka, B., Marti, H.-P., Chen, T.J., Magiera-Mularz, K., Zieba, B., Holak, T.A., Dabrowski, J.M., Czarna, A., Koziel, J., Mydel, P., Dubin, G.
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15, strony: 687), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15060697 - link to the publication

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