Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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2-ketoglutarate and 2-hydroxyglutarate as a potential metabolic modulators of an active DNA demethylation process among colorectal cancer patients.

2017/25/N/NZ5/00378

Keywords:

colorectal cancer epigenetic modifications glutarates TETs UPLC-MS/MS

Descriptors:

  • NZ5_5: Diagnostics in human diseases
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Martyna Modrzejewska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 120 000 PLN

Project start date (Y-m-d): 2018-02-13

Project end date (Y-m-d): 2021-02-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do oznaczania próbek laboratoryjnych BRADY.
  2. Czytnik ELISA z oprogramowaniem (22 500 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. Normalization of metabolic data to total thymine content and its application to determination of 2-hydroxyglutarate
    Authors:
    Martyna Modrzejewska*, Maciej Gawronski , Daniel Gackowski
    Academic press:
    Analytical Biochemistry (rok: 2021, tom: 618, strony: 45299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ab.2021.114129 - link to the publication
  1. D-2-hydroxyglutarate as a possible biomarker of progressing inflammatory bowel diseases to colorectal cancer. The clinical approach.
    Authors:
    Modrzejewska M, Gackowski D, Szpotan J, Foksiński M
    Conference:
    The 43rd FEBS Congress Biochemistry Forever 2018 (rok: 2018, ), Wydawca: FEBS Open Bio 2018 : Vol. 8, suppl. 1, s. 286.
    Data:
    konferencja 7-12.07
    Status:
    Published
  2. A simple UPLC-UV method for normalization of cellular concentration of metabolites involved in an active DNA demethylation process
    Authors:
    Modrzejewska M, Gawroński M, Starczak M, Foksiński M, Gackowski D
    Conference:
    3rd Congress of Polish Biosciences BIO2018 "Through interdisciplinary approach into new solutions' (rok: 2018, ), Wydawca: Acta Biochim. Pol. 2018 : Vol. 65, suppl. 2, s. 98.
    Data:
    konferencja 18-21.09
    Status:
    Published

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