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The impact of mother's milk microbiome, child's alimentary tract microbiome and child's skin micobiome on clinical course, natural tollerance development and methylation of selected genes involved in immune regulation in children with food allergy.

2017/25/B/NZ5/00141

Keywords:

food allergy tollerance microbiome epigenetics

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_1: Etiology of human diseases
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Lekarski

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Grzybowski 

Number of co-investigators in the project: 8

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 753 020 PLN

Project start date (Y-m-d): 2018-01-19

Project end date (Y-m-d): 2023-01-18

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study
    Authors:
    Ewa Łoś-Rycharska, Marcin Gołębiewski , Marcin Sikora, Tomasz Grzybowski, Marta Gorzkiewicz, Maria Popielarz, Julia Gawryjołek, Aneta Krogulska
    Academic press:
    Nutrients (rok: 2021, tom: 13, strony: 1682), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu13051682 - link to the publication
  2. The methylation profile of IL4, IL5, IL10, IFNG and FOXP3 associated with environmental exposures differed between Polish infants with the food allergy and/or atopic dermatitis and without the disease
    Authors:
    Marta Gorzkiewicz, Ewa Łoś-Rycharska, Julia Gawryjołek, Marcin Gołębiewski, Aneta Krogulska, Tomasz Grzybowski
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14, strony: 14:1209190), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1209190 - link to the publication
  3. Mother's Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
    Authors:
    Marcin Gołębiewski, Ewa Łoś-Rycharsk, Marcin Sikora, Tomasz Grzybowski, Marta Gorzkiewicz, Aneta Krogulska
    Academic press:
    Nutrients (rok: 2021, tom: 13(10), strony: 3600), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu13103600 - link to the publication
  4. The microbiome and its impact on food allergy and atopic dermatitis in children.
    Authors:
    Łoś-Rycharska Ewa, Gołębiewski Marcin, Grzybowski Tomasz, Rogalla-Ładniak Urszula, Krogulska Aneta
    Academic press:
    Advances in Dermatology and Allergology (rok: 2020, tom: 5, strony: 641-650), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/ada.2019.90120. - link to the publication

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