Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Glycation and kynurenine pathway in modulation of cancer microenvironment

2017/25/B/NZ4/01198

Keywords:

AGEs kynurenine cancer immune regulation

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_12: Other related subjects
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Katolicki Uniwersytet Lubelski Jana Pawła II Wydział Nauk Ścisłych i Nauk o Zdrowiu

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Staniszewska 

Number of co-investigators in the project: 4

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 067 780 PLN

Project start date (Y-m-d): 2018-02-06

Project end date (Y-m-d): 2023-01-05

Project duration:: 59 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikroskop odwrócony (30 000 PLN)
  2. wirówka (8 000 PLN)
  3. Wirówka (40 000 PLN)
  4. pojemnik na ciekły azot (18 000 PLN)
  5. Termocykler (50 000 PLN)
  6. Apart do elektroforezy w żelu agarozowym (10 000 PLN)
  7. Apart do elektrofprezy 2D (20 000 PLN)
  8. Aspirator do plynów (6 000 PLN)
  9. wirówka.

Information in the final report

  • Publication in academic press/journals (9)
  1. Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures
    Authors:
    Ilona Sadok, Kamila Rachwał, Magdalena Staniszewska
    Academic press:
    Journal of Visualized Experiments (rok: 2020, tom: 159, strony: https://www.jove.com/video/61031), Wydawca: MyJoVE Corporation
    Status:
    Published
    DOI:
    10.3791/61031 - link to the publication
  2. Improved Voltammetric Determination of Kynurenine at the Nafion Covered Glassy Carbon Electrode – Application in Samples Delivered from Human Cancer Cells
    Authors:
    I. Sadok, K. Tyszczuk-Rotko, R. Mroczka, J. Kozak, M. Staniszewska
    Academic press:
    International Journal of Tryptophan Research (rok: 2021, tom: 14, strony: 45305), Wydawca: SAGE Publication Ltd.
    Status:
    Published
    DOI:
    10.1177/11786469211023468 - link to the publication
  3. Kynurenine and anthranilic acid in the peritoneum correlate with the stage of gastric cancer disease
    Authors:
    9.K. Gęca, K. Rawicz-Pruszyński, R. Mlak, I. Sadok, W.P. Polkowski, M. Staniszewska
    Academic press:
    International Journal of Tryptophan Research (rok: 2022, tom: 15, strony: 45301), Wydawca: SAGE Publication Ltd.
    Status:
    Published
    DOI:
    10.1177/11786469211065620 - link to the publication
  4. Reliable chromatographic assay for measuring of indoleamine 2,3-dioxygenase (IDO) activity in human cancer cells
    Authors:
    I. Sadok, K. Rachwał, I. Jonik, M. Staniszewska
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2021, tom: 36, strony: 581-592), Wydawca: Taylor and Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2021.1882451 - link to the publication
  5. Reliable chromatographic assay for measuring of indoleamine 2,3-dioxygenase 1 (IDO1) activity in human cancer cells
    Authors:
    Ilona Sadok , Kamila Rachwał , Ilona Jonik and Magdalena Staniszewska
    Academic press:
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (rok: 2021, tom: 36, strony: 581-592), Wydawca: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2021.1882451 - link to the publication
  6. UHPLC-ESI-MS/MS Quantification of Relevant Substrates and Metabolites of the Kynurenine Pathway Present in Serum and Peritoneal Fluid from Gastric Cancer Patients—Method Development and Validation
    Authors:
    I. Sadok, K. Jędruchniewicz, K. Rawicz-Pruszyński, M. Staniszewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6972-6992), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136972 - link to the publication
  7. Analysis of the Site-Specific Myoglobin Modifications in the Melibiose-Derived Novel Advanced Glycation End-Product.
    Authors:
    Gostomska-Pampuch K, Wiśniewski JR, Sowiński K, Gruszecki WI, Gamian A, Staniszewska M
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(21), strony: 13036), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232113036 - link to the publication
  8. Application of the optimized and validated LC–MS method for simultaneous quantification of tryptophan metabolites in culture medium from cancer cells
    Authors:
    Ilona Sadok, Kamila Rachwał, Magdalena Staniszewska
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2019, tom: 176, strony: 112895-112816), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2019.112805 - link to the publication
  9. Proteins in human body fluids contain in vivo antigen analog of the melibiose-derived glycation product: MAGE
    Authors:
    Gostomska-Pampuch K., Gamian A., Rawicz-Pruszyński K., Gęca K., Tkaczuk-Włach J., Jonik I., Ożga K., Staniszewska M.
    Academic press:
    Scientific Reports (rok: 2022, tom: 12(1), strony: 7520), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-11638-2 - link to the publication

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