Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The effects of thyroid hormones in the brain in an animal model of depression

2017/25/B/NZ7/01708

Keywords:

depression thyroid hormones metabolism cognitive processes

Descriptors:

  • NZ7_4: Prevention in population health
  • NZ4_8: Neuroendocrinology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bogusława Budziszewska 

Number of co-investigators in the project: 7

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 550 556 PLN

Project start date (Y-m-d): 2018-01-19

Project end date (Y-m-d): 2021-09-18

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Labirynt T dla szczurów wraz z kamerą (15 000 PLN)
  2. OROBOROS - Oksygraf-2k; Modułowy system respirometrii i fluorymetrii o wysokiej rozdzielczości (335 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (6)
  1. Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression
    Authors:
    Katarzyna Głombik, Jan Detka, Bartosz Bobula, Joanna Bąk, Magdalena Kusek, Krzysztof Tokarski, Bogusława Budziszewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1599), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute)
    Status:
    Published
    DOI:
    10.3390/ijms22041599 - link to the publication
  2. Hormonal regulation of oxidative phosphorylation in the brain in health and disease
    Authors:
    Katarzyna Głombik, Jan Detka, Bogusława Budziszewska
    Academic press:
    Cells (rok: 2021, tom: 10, strony: Cells 2021, 10 (11), 2937), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute)
    Status:
    Published
    DOI:
    10.3390/cells10112937 - link to the publication
  3. Impaired brain energy metabolism: involvement in depression and hypothyroidism
    Authors:
    Katarzyna Głombik, Jan Detka, Anna Kurek, Bogusława Budziszewska
    Academic press:
    Frontiers in Neurosciences (rok: 2020, tom: 14, strony: 45312), Wydawca: James A. Carr, Texas Tech University, United States
    Status:
    Published
    DOI:
    10.3389/fnins.2020.586939 - link to the publication
  4. Mitochondria-targeting therapeutic strategies in the treatment of depression
    Authors:
    Katarzyna Głombik, Bogusława Budziszewska, Agnieszka Basta-Kaim
    Academic press:
    Mitochondrion (rok: 2021, tom: 58, strony: 169-178), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.mito.2021.03.006 - link to the publication
  5. Venlafaxine and L-Thyroxine Treatment Combination: Impact on Metabolic and Synaptic Plasticity Changes in an Animal Model of Coexisting Depression and Hypothyroidism
    Authors:
    Katarzyna Głombik, Jan Detka, Bogusława Budziszewska
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1394), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute)
    Status:
    Published
    DOI:
    10.3390/cells10061394 - link to the publication
  1. Regulation of the glycolysis process in the brain in an animal model of coexisting depression and hypothyroidism: combined efficacy of venlafaxine and L-thyroxine.
    Authors:
    Głombik K, Detka J, Budziszewska B.
    Conference:
    Virtual FENS Regional Meeting 2021; 25-27 August 2021 (rok: 2021, ), Wydawca: Book of Abstracts
    Data:
    konferencja 2021-08-25-27
    Status:
    Published
  2. Brain energy metabolism in an animal model of the co-occurrence of depression and hypothyroidism.
    Authors:
    Głombik K, Detka J, Kurek A, Budziszewska B.
    Conference:
    7th ESE Young Endocrinologists And Scientists (EYES) Meeting, Ateny, Grecja (rok: 2019, ), Wydawca: Opublikowane Endocrine Abstracts, November 2019 Volume 67
    Data:
    konferencja 2019-09-13-15
    Status:
    Published
  3. Chronic treatment with L-thyroxine decreases the level of cleaved caspase-1 (p20) in the frontal cortex and hippocampus in an animal model of coexisting depression and hypothyroidism.
    Authors:
    Detka J, Głombik K, Budziszewska B.
    Conference:
    Virtual FENS Regional Meeting 2021; 25-27 August 2021 (rok: 2021, ), Wydawca: Book of Abstracts
    Data:
    konferencja 2021-08-25-27
    Status:
    Published
  4. Dysregulation of the brain pyruvate dehydrogenase in an animal model of coexistence of depression and hypothyroidism
    Authors:
    Głombik K, Detka J, Kurek A, Budziszewska B.
    Conference:
    FENS Regional Meeting 2019 (FRM2019), BELGRAD, SERBIA (rok: 2019, ), Wydawca: Serbian Neuroscience Society, Abstract book
    Data:
    konferencja 2019-07-10-13
    Status:
    Published
  5. Thyroid hormone regulation of brain metabolism: Study in an animal model of the co-occurrence of depression and hypothyroidism
    Authors:
    Katarzyna Glombik, Jan Detka, Boguslawa Budziszewska
    Conference:
    22nd European Congress of Endocrinology (rok: 2020, ), Wydawca: Endocrine Abstracts (2020) 70 AEP899
    Data:
    konferencja 05 - 09 September 2020 - Online
    Status:
    Published
  6. Metabolic changes in the rat brain in an animal model of coexistence of depression and hypothyroidism
    Authors:
    Budziszewska B., Głombik K., Detka J., Kurek A., Basta-Kaim A.
    Conference:
    7th Conference of the Mediterranean Neuroscience Society Conference, MNS 209, Marrakech, Morocco (rok: 2019, ), Wydawca: Mediterranean Neuroscience Society
    Data:
    konferencja 2019-06-23-27
    Status:
    Published

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