Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Functional study of rare BRAF mutations on liver cancer development using CRISPR/Cas9 system

2017/25/N/NZ5/01885

Keywords:

BRAF mutations liver cancer CRISPR/Cas9

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_1: Etiology of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Genetyki i Biotechnologii Zwierząt Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Magdalena Śmiech 

Number of co-investigators in the project: 2

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 180 000 PLN

Project start date (Y-m-d): 2018-02-07

Project end date (Y-m-d): 2021-08-06

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Book publications / chapters in book publications (1)
  1. Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks
    Authors:
    Magdalena Śmiech, Paweł Leszczyński, Hidetoshi Kono, Christopher Wardell, Hiroaki Taniguchi
    Academic press:
    Genes (rok: 2020, tom: 11, strony: 1–14), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/genes11111342 - link to the publication
  2. Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression
    Authors:
    Magdalena Śmiech, Paweł Leszczyński, Christopher Wardell, Piotr Poznański, Mariusz Pierzchała, Hiroaki Taniguchi
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1548), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms23031548 - link to the publication
  1. Cloning-Free (DNA-Free) CRISPR-Cas9-Mediated Gene Editing in Human Liver Cell Line and Its Detection
    Authors:
    Magdalena Śmiech, Paweł Leszczyński, Effi Haque, Hiroaki Taniguchi
    Book:
    CRISPR-Cas Methods (rok: 2020, tom: brak, strony: 163-171), Wydawca: Springer Protocols Handbooks
    Status:
    Published

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