Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Lsr2 protein as a global chromosomal organizer and transcription factor in Mycobacterium - an interplay of Lsr2 with SMC complex and HupB

2017/25/B/NZ1/00657

Keywords:

Lsr2 HupB SMC bacterial chromosome Mycobacterium transcription factor

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jolanta Zakrzewska-Czerwińska 

Number of co-investigators in the project: 6

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 906 000 PLN

Project start date (Y-m-d): 2018-01-10

Project end date (Y-m-d): 2021-07-09

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Homogenizator do wydajnej i powtarzalnej lizy komórek Mycobacterium (60 000 PLN)
  2. Zestaw do elektroforezy kapilarnej do analizy jakości kwasów nukleinowych (150 000 PLN)
  3. komputer.
  4. System dokumentacji żeli agarozowych.
  5. System Mikroprzepływowy CellASIC ONIX 2 wraz z podstawowym zestawem drenów (100 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Lsr2, a nucleoid-associated protein influencing mycobacterial cell cycle
    Authors:
    Kołodziej M, Trojanowski D, Bury K, Hołówka J, Matysik W, Kąkolewska H, Feddersen H, Giacomelli G, Konieczny I, Bramkamp M, Zakrzewska-Czerwińska J.
    Academic press:
    Sci Rep. (rok: 2021, tom: 11(1), strony: 2910), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-021-82295-0 - link to the publication
  2. Thiosemicarbazide Derivatives Decrease the ATPase Activity of Staphylococcus aureus Topoisomerase IV, Inhibit Mycobacterial Growth, and Affect Replication in Mycobacterium smegmatis
    Authors:
    Aleksandra Kowalczyk, Agata Paneth, Damian Trojanowski, Piotr Paneth, Jolanta Zakrzewska-Czerwińska, Paweł Stączek
    Academic press:
    Interenational Journal of Molecular Sciences (rok: 2021, tom: 22(8), strony: 3881), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22083881 - link to the publication
  3. Lsr2 and its novel paralogue mediate the adjustment of Mycobacterium smegmatis to unfavorable environmental conditions
    Authors:
    Marta Kołodziej, Tomasz Łebkowski, Przemysław Płociński, Joanna Hołówka, Mariola Paściak, Bartosz Wojtaś, Katarzyna Bury, Igor Konieczny, Jarosław Dziadek, Jolanta Zakrzewska-Czerwińska
    Academic press:
    mSphere (rok: 2021, tom: 6 (3), strony: e00290-21), Wydawca: ASM
    Status:
    Published
    DOI:
    10.1128/mSphere.00290-21 - link to the publication
  4. Molekularne podstawy organizacji chromatyny bakteryjnej
    Authors:
    Marta Kołodziej Jolanta Zakrzewska-Czerwinska, Joanna Hołówka
    Academic press:
    Postępy Biochemii (rok: 2019, tom: 65, strony: 202-211), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2019_270 - link to the publication
  5. Watching DNA Replication Inhibitors in Action: Exploiting Time-Lapse Microfluidic Microscopy as a Tool for Target-Drug Interaction Studies in Mycobacterium
    Authors:
    Damian Trojanowski, Marta Kołodziej, Joanna Hołówka, Rolf Müller, Jolanta Zakrzewska-Czerwińska
    Academic press:
    Antimicrob Agents Chemother (rok: 2019, tom: 63(10), strony: 45307), Wydawca: ASM
    Status:
    Published
    DOI:
    10.1128/AAC.00739-19 - link to the publication
  6. Where and When Bacterial Chromosome Replication Starts: A Single Cell Perspective
    Authors:
    Damian Trojanowski, Joanna Hołowka Jolanta Zakrzewska-Czerwińska
    Academic press:
    Front. Microbiol. (rok: 2018, tom: 9, strony: 2819), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2018.02819 - link to the publication
  7. Nucleoid Associated Proteins: The Small Organizers That Help to Cope With Stress
    Authors:
    Joanna Hołówka, Jolanta Zakrzewska-Czerwińska
    Academic press:
    Front. Microbiol. (rok: 2020, tom: 11, strony: 45298), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2020.00590 - link to the publication