Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Evaluation of the influence of progressive noradrenergic neurodegeneration on dopaminergic system functioning in context of presymptomatic phase of Parkinson's disease.

2017/25/B/NZ7/02406

Keywords:

noradrenergic system dopaminergic system transgenic models Parkinson's disease

Descriptors:

  • NZ7_14:
  • NZ4_9:
  • NZ5_3:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Grzegorz Kreiner 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 620 000 PLN

Project start date (Y-m-d): 2018-01-03

Project end date (Y-m-d): 2023-07-02

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie do archiwizacji i dokumentacji przebiegu projektu (15 000 PLN)
  2. Laptop z podstawowym oprogramowaniem DTP.
  3. Elektroporator (41 200 PLN)
  4. Laptop z podstawowym oprogramowaniem DTP (10 000 PLN)
  5. Stolik stereotaktyczny z pompą infuzyjną.
  6. Wirówka z chłodzeniem (32 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (9)
  1. Genetic lesions of the noradrenergic system trigger induction of oxidative stress and inflammation in the ventral midbrain
    Authors:
    Barut J, Rafa-Zabłocka K, Jurga AM, Bagińska M, Nalepa I, Parlato R, Kreiner G
    Academic press:
    Neurochemistry International (rok: 2022, tom: 155, strony: 45667), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2022.105302 - link to the publication
  2. What have we learned recently from transgenic mouse models about neurodegeneration? The most promising discoveries of this millennium
    Authors:
    Kreiner G
    Academic press:
    Pharmacol Rep (rok: 2018, tom: 70, strony: 1105-1115), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.09.006 - link to the publication
  3. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism
    Authors:
    Kreiner G, Rafa-Zabłocka K, Barut J, Chmielarz P, Kot M, Bagińska M, Parlato R, Daniel WA, Nalepa I
    Academic press:
    Scientific Reports (rok: 2019, tom: 4,02916666666667, strony: 45666), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.3389/fnmol.2019.00106. - link to the publication
  1. The influence of genetically induced loss of noradrenergic neurons on the proand anti-inflammatory markers in the SN/VTA neurons of mice.
    Authors:
    Rafa-Zabłocka K, Barut J, Bagińska M, Nalepa I, Kreiner G
    Conference:
    FENS Regional Meeting (rok: 2021, ), Wydawca: Polish Neuroscience Society
    Data:
    konferencja 25-27.08.2021
    Status:
    Published
  2. E!cient cell-type specific mutagenesis in adult neurons using single, conditional, lentiviral CRISPR/Cas9 vectors - new strategy to study early eects of noradrenergic cells degeneration in Parkinson's disease.
    Authors:
    Barut J, Rafa-Zabłocka K, Wilczkowski M, Baginska M, Domanskyi A, Herian M, Gołembiowska K, Kreiner G
    Conference:
    51st Annual Meeting of SfN - Neuroscience 2022 (rok: 2022, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 12-16.11.2022
    Status:
    Published
  3. Utilization of conditional single lentivirus CRISPR/Cas9 vector for efficient gene knockout generation in adult neurons in vivo and in vitro
    Authors:
    Barut J, Rafa-Zabłocka K, Chmielarz P, Bagińska M, Domanskyi A, Kreiner G
    Conference:
    FENS Regional Meeting (rok: 2021, ), Wydawca: Polish Neuroscience Society
    Data:
    konferencja 25-27.08.2021
    Status:
    Published
  4. Evaluation of the TIF-IA-deficient mouse model of slow progressive noradrenergic degeneration as a tool to study presymptomatic phase of Parkinson's disease
    Authors:
    Rafa-Zabłocka K, Barut J, Baginska M, Domanskyi A, Nalepa I, Kreiner G
    Conference:
    FENS 2020 Virtual Forum | International Neuroscience (rok: 2020, ), Wydawca: FENS
    Data:
    konferencja 11-15.07
    Status:
    Published
  5. Exploitation of in-vitro and in-vivo models characterized by enhancement of astrocytes upon noradrenergic targeting for study of presymptomatic Parkinson's disease
    Authors:
    Barut J, Rafa-Zabłocka K, Jurga A, Bagińska M, Nalepa I, Parlato R, Kreiner G
    Conference:
    34th ECNP Congress (rok: 2021, ), Wydawca: Elsevier
    Data:
    konferencja 2-5.10.2021
    Status:
    Published
  6. Transgenic mice with progressive degeneration of noradrenergic neurons restricted to locus coeruleus present depressive-like behavior and motor disturbances
    Authors:
    Rafa-Zablocka K, Barut J, Baginska M, Kreiner G
    Conference:
    35th ECNP Congress (rok: 2022, ), Wydawca: Elsevier
    Data:
    konferencja 15-18.10.2022
    Status:
    Published
  7. Single, conditional, lentiviral CRISPR/Cas9 vectors for efficient mutagenesis in neurons – a possible new strategy for modeling prodromal Parkinson's disease
    Authors:
    Barut J, Rafa-Zabłocka K, Chmielarz P, Domanskyi A, Baginska M, Herian M, Gołembiowska K, Kreiner G
    Conference:
    35th ECNP Congress (rok: 2022, ), Wydawca: Elsevier
    Data:
    konferencja 15-18.10.2022
    Status:
    Published
  8. Phenotypic alterations observed in mice genetically depleted of Dbh-expressing cells in the locus coeruleus associated with the prodromal symptoms of Parkinson's disease
    Authors:
    Rafa-Zablocka K, Barut J, Kreiner G
    Conference:
    51st Annual Meeting of SfN - Neuroscience 2022 (rok: 2022, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 12-16.11.2022
    Status:
    Published
  9. Effects of genetic impairment of the noradrenergic system on the expression of inflammatory markers in the SN/VTA neurons of mice.
    Authors:
    Rafa-Zabłocka K, Barut J, Bagińska M, Nalepa I, Kreiner G
    Conference:
    4th Central European Biomedical Congress (rok: 2021, ), Wydawca: CEBC Abstracts
    Data:
    konferencja 7-9.06.2021
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy