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Rutin and ascorbic acid cooperation in cytoprotective effect on fibroblasts and keratinocytes exposed to UVA and UVB radiation

2017/25/N/NZ7/00863

Keywords:

rutin ascorbic acid skin cells UV radiation lipidomics protomics polyteraphy

Descriptors:

  • NZ7_3: Physical culture and health promotion
  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agnieszka Gęgotek 

Number of co-investigators in the project: 3

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 151 872 PLN

Project start date (Y-m-d): 2018-01-10

Project end date (Y-m-d): 2022-01-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (4)
  1. Cytoprotective effect of ascorbic acid and rutin against oxidative changes in the proteome of skin fibroblasts cultured in a three-dimensional system
    Authors:
    Gęgotek Agnieszka, Jarocka-Karpowicz Iwona, Skrzydlewska Elżbieta
    Academic press:
    Nutrients (rok: 2020, tom: 12, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu12041074 - link to the publication
  2. Exogenous antioxidants impact on UV-induced changes in membrane phospholipids and the effectiveness of the endocannabinoid system in human skin cells
    Authors:
    Gęgotek Agnieszka, Jastrząb Anna, Dobrzyńska Marta, Biernacki Michał, Skrzydlewska Elżbieta
    Academic press:
    Antioxidants (rok: 2021, tom: 10, strony: 1260), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10081260 - link to the publication
  3. Rutin and ascorbic acid cooperation in antioxidant and antiapoptotic effect on human skin keratinocytes and fibroblasts exposed to UVA and UVB radiation
    Authors:
    Agnieszka Gęgotek, Ewa Ambrożewicz, Anna Jastrząb, Iwona Jarocka-Karpowicz, Elżbieta Skrzydlewska
    Academic press:
    Archives of Dermatological Research (rok: 2019, tom: brak, strony: 45308), Wydawca: SpringerLink
    Status:
    Published
    DOI:
    10.1007/s00403-019-01898-w - link to the publication
  4. Biological effect of protein modifications by lipid peroxidation products
    Authors:
    Agnieszka Gęgotek, Elżbieta Skrzydlewska
    Academic press:
    Chemistry and Physics of Lipids (rok: 2019, tom: 221, strony: 46-52), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chemphyslip.2019.03.011 - link to the publication
  5. Effects of natural antioxidants on phospholipid and ceramide profiles of 3D-cultured skin fibroblasts exposed to UVA or UVB radiation
    Authors:
    Gęgotek Agnieszka, Łuczaj Wojciech, Skrzydlewska Elżbieta
    Academic press:
    Antioxidants (rok: 2021, tom: 10, strony: 578), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10040578 - link to the publication
  6. Natural exogenous antioxidants defense against changes in human skin fibroblasts proteome disturbed by UVA radiation
    Authors:
    Agnieszka Gęgotek, Pedro Domingues, Elżbieta Skrzydlewska
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2020, tom: 2020, strony: 3216415), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/3216415 - link to the publication
  7. Synergistic cytoprotective effects of rutin and ascorbic acid on the proteomic profile of 3D- cultured keratinocytes exposed to UVA or UVB radiation.
    Authors:
    Agnieszka Gęgotek, Iwona Jarocka-Karpowicz, Elżbieta Skrzydlewska
    Academic press:
    Nutrients (rok: 2019, tom: 11, strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu11112672 - link to the publication
  1. Ascorbic acid and rutin cooperation in protecting of the proteome of UV irradiated fibroblasts cultured in a three-dimensional system
    Authors:
    Gęgotek Agnieszka, Domingues Pedro, Skrzydlewska Elżbieta
    Conference:
    20th Biennial Meeting of SFRR International (rok: 2021, ), Wydawca: brak
    Data:
    konferencja 15-18.03.2021
    Status:
    Published
  2. Effect of natural antioxidants and lipid peroxidation products on keratinocyte proteomic profile
    Authors:
    Gęgotek Agnieszka, Bielawska Katarzyna, Skrzydlewska Elżbieta
    Conference:
    7th European Lipidomics Meeting (rok: 2018, ), Wydawca: brak
    Data:
    konferencja 26-29.09.2018
    Status:
    Published
  3. Rutin and ascorbic acid cooperation in protection against UV-induced oxidative PTMs of proteins in 3D cultured keratinocytes
    Authors:
    Agnieszka Gęgotek, Sinemyiz Atalay, Elżbieta Skrzydlewska
    Conference:
    Advances in the Study of Lipid and Protein Oxidation: From Methods to Targets (rok: 2019, ), Wydawca: brak
    Data:
    konferencja 13-15.03.2019
    Status:
    Published
  4. The differences in rutin and ascorbic acid mechanism action against UV-induced changes in human skin fibroblasts
    Authors:
    Gęgotek Agnieszka, Łuczaj Wojciech, Ambrożewicz Ewa, Skrzydlewska Elżbieta
    Conference:
    9th International Conference on Skin Ageing & Challenges (rok: 2018, ), Wydawca: brak
    Data:
    konferencja 25-27.02.2018
    Status:
    Published

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