Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Optimization of supramolecular helicates size in terms of interaction with DNA and antitumor activity

2017/24/C/ST5/00181

Keywords:

helicate silver(I) copper(I) DNA anticancer activity

Descriptors:

  • ST5_12: Methods of nanomaterials/materials synthesis
  • ST5_14: Other related subjects
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Fik 

Number of co-investigators in the project: 3

Call: SONATINA 1 - announced on 2016-12-15

Amount awarded: 497 853 PLN

Project start date (Y-m-d): 2017-11-03

Project end date (Y-m-d): 2020-03-02

Project duration:: 28 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Optimization of supramolecular helicates size in terms of interaction with DNA and antitumor activity

2017/24/C/ST5/00181

Keywords:

helicate silver(I) copper(I) DNA anticancer activity

Descriptors:

  • ST5_12: Methods of nanomaterials/materials synthesis
  • ST5_14: Other related subjects
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Fik 

Number of co-investigators in the project: 3

Call: SONATINA 1 - announced on 2016-12-15

Amount awarded: 497 853 PLN

Project start date (Y-m-d): 2017-11-03

Project end date (Y-m-d): 2020-03-02

Project duration:: 28 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Dynamic Helicates Self-Assembly from Homo and Heterotopic Dynamic Covalent Ligand Strands
    Authors:
    Antonio Santoro, Jan Holub, Marta Fik-Jaskółka, Ghislaine Vantomme, Jean-Marie Lehn
    Academic press:
    Chemistry - A European Journal (rok: 2020, tom: 26, strony: 15664-15671), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/chem.202003496 - link to the publication
  2. New Artificial Biomimetic Enzyme Analogues Based on Iron(II/III) Schiff Base Complexes: An Effect of (Benz)imidazole Organic Moieties on Phenoxazinone Synthase and DNA Recognition
    Authors:
    Aleksandra Bocian, Martyna Szymańska, Daria Brykczyńska, Maciej Kubicki, Monika Wałęsa-Chorab, Giovanni N. Roviello, Marta A. Fik-Jaskółka, Adam Gorczyński, Violetta Patroniak
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 3173), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24173173 - link to the publication
  3. Luminescent pyrenyl-GNA nucleosides: synthesis, photophysics and confocal microscopy studies in cancer HeLa cells
    Authors:
    Joanna Skiba, Aleksandra Kowalczyk, Marta A. Fik, Magdalena Gapińska, Damian Trzybiński, Krzysztof Woźniak, Valerije Vrček, Rafał Czerwieniec, Konrad Kowalski
    Academic press:
    Photochemical & Photobiological Sciences (rok: 2019, tom: 18, strony: 2449-2460), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9pp00271e - link to the publication
  4. Spectroscopic and SEM evidences for G4-DNA binding by a synthetic alkyne-containing amino acid with anticancer activity
    Authors:
    Marta A. Fik-Jaskółka, Anna F. Mkrtchyan, Ashot S. Saghyan, Rosanna Palumbo, Agnieszka Belter, Liana A. Hayriyan, Hayarpi Simonyan, Valentina Roviello, Giovanni N. Roviello
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2020, tom: 229, strony: 117884), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.117884 - link to the publication
  5. Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect
    Authors:
    Marta A. Fik-Jaskółka, Izabela Pospieszna-Markiewicz, Giovanni N. Roviello, Maciej Kubicki, Wanda Radecka-Paryzek, Violetta Patroniak
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 2122-2126), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.0c03260 - link to the publication
  6. Anthracene-thymine luminophores: Synthesis, photophysical properties, and imaging in living HeLa cells
    Authors:
    Artur Jabłoński, Aleksandra Kowalczyk, Marta A. Fik, Damian Trzybiński, Krzysztof Woźniak, Katerina Vinogradova, Sława Glińska, Valerije Vrček, Rafał Czerwieniec, Konrad Kowalski
    Academic press:
    Dyes and Pigments (rok: 2019, tom: 170, strony: 107554), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2019.107554 - link to the publication
  7. Biological macromolecule binding and anticancer activity of synthetic alkyne-containing L-phenylalanine derivatives
    Authors:
    Marta A. Fik-Jaskółka, Anna F. Mkrtchyan, Ashot S. Saghyan, Rosanna Palumbo, Agnieszka Belter, Liana A. Hayriyan, Hayarpi Simonyan, Valentina Roviello, Giovanni N. Roviello
    Academic press:
    Amino Acids (rok: 2020, tom: 52, strony: 755-769), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s00726-020-02849-w - link to the publication
  8. Co(II/III) Complexes with Benzoxazole and Benzothiazole Ligands as Efficient Heterogenous Photocatalysts for Organic Dyes Degradation
    Authors:
    Martyna Szymańska, Włodzimierz Czepa, Cezary Hołubowicz, Renata Świsłocka, Teresa Łuczak, Maciej Kubicki, Joanna Karpińska, Marta A. Fik-Jaskółka, Violetta Patroniak
    Academic press:
    Catalysts (rok: 2019, tom: 9, strony: 913), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal9110913 - link to the publication
  9. Thiophene-benzothiazole dyad ligand and its Ag(I) complex – Synthesis, characterization, interactions with DNA and BSA
    Authors:
    Martyna Szymańska, Małgorzata Insińska-Rak, Grzegorz Dutkiewicz, Giovanni N. Roviello, Marta A. Fik-Jaskółka, Violetta Patroniak
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 319, strony: 114182), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.114182 - link to the publication

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