Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Efficient simulation algorithms for models of stochastic processes in computational biology and synthesis of the signaling pathways models.

2016/23/B/ST6/03455

Keywords:

computational biology signaling pathways modelling and simulation

Descriptors:

  • ST6_13: Bioinformatics, biocomputing, DNA and molecular computation
  • ST6_12: Scientific computing, simulation and modelling tools
  • ST7_4: Micro- and nanosystems engineering

Panel:

ST6 - Computer science and informatics: informatics and information systems, computer science, scientific computing, intelligent systems

Host institution :

Politechnika Śląska, Wydział Automatyki, Elektroniki i Informatyki

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Krzysztof Puszyński 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 895 400 PLN

Project start date (Y-m-d): 2017-08-24

Project end date (Y-m-d): 2021-08-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer przenośny (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (3)
  • Book publications / chapters in book publications (3)
  1. Petri nets and ODEs as complementary methods for comprehensive analysis on an example of the ATM–p53–NF-κB signaling pathways
    Authors:
    Gutowska K, Kogut D, Kardynska M, Formanowicz P, Smieja J, Puszynski K
    Academic press:
    Scientific Reports (rok: 2021, tom: N.A., strony: N.A.), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-022-04849-0 - link to the publication
  2. Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling
    Authors:
    Paszek A, Kardyńska M, Begnall J, Smieja J, Spiller D, Widlak P, Kimmel M, Widlak W, Paszek P
    Academic press:
    Cell Communication and Signaling (rok: 2020, tom: 18, strony: 45312), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-020-00583-0 - link to the publication
  3. Activation of the atypical NF-κB pathway induced by ionizing radiation is not affected by a p53 status.
    Authors:
    Gracjana Zając, Marek Rusin, Barbara Łasut-Szyszka, Krzysztof Puszyński, Piotr Widłak
    Academic press:
    Acta Biochimica Polonica (rok: 2021, tom: N.A., strony: N.A.), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2020_5942 - link to the publication
  4. Application of Sensitivity Analysis for Molecular Drug Targets Searching with Regard to the NF-κB Signaling Pathway
    Authors:
    Kardyńska M, Smieja J, Puszynski K
    Academic press:
    International Journal of Pharma Medicine and Biological Sciences (rok: 2021, tom: 1, strony: 82-87), Wydawca: IJPMBS
    Status:
    Published
    DOI:
    10.2.82-87 - link to the publication
  5. Sensitivity Analysis Aimed at Finding Potential Molecular Drug Targets
    Authors:
    Jaroslaw Smieja, Małgorzata Kardyńska, Marta Pudlo
    Academic press:
    Mathematica Applicanda (Matematyka Stosowana) (rok: 2019, tom: 47 (2), strony: 197-205), Wydawca: Polskie Towarzystwo Matematyczne
    Status:
    Published
    DOI:
    10.14708/ma.v47i2.6488 - link to the publication
  6. Application of sensitivity analysis to discover potential molecular drug targets
    Authors:
    Malgorzata Kardynska, Jaroslaw Smieja, Pawel Paszek, Krzysztof Puszynski
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: n.d., strony: n.d.), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  7. Computational determination of the optimal dose of the cis-platinum to maximize the life time of patients diagnosed with cancer
    Authors:
    Emilia Kozłowska, Krzysztof Puszynski
    Academic press:
    Mathematica Applicanda (Matematyka Stosowana) (rok: 2019, tom: 47 (2), strony: 187-196), Wydawca: Polskie Towarzystwo Matematyczne
    Status:
    Published
    DOI:
    10.14708/ma.v47i2.6485 - link to the publication
  8. Piece-wise linear models of biological systems - Application, analysis, and comparison with nonlinear models using the example of the p53 regulatory module
    Authors:
    Magdalena Ochab, Krzysztof Puszynski
    Academic press:
    Plos One (rok: 2020, tom: 1, strony: 20), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0243823 - link to the publication
  9. Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level.
    Authors:
    Kardyńska M, Paszek A, Smieja J, Spiller D, Widlak W, White MR, Paszek P, Kimmel M
    Academic press:
    Plos Computational Biology (rok: 2018, tom: 14, strony: 25), Wydawca: Plos Computational Biology
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1006130 - link to the publication
  10. Single stranded-DNA detection: the role of Wip1 in ATR-dependent pathway.
    Authors:
    Kurpas M, Jonak K, Puszynski K
    Academic press:
    Mathematica Applicanda (Matematyka Stosowana) (rok: 2018, tom: 46, strony: 10), Wydawca: Polskie Towarzystwo Matematyczne
    Status:
    Published
    DOI:
    10.14708/ma.v46i1.6375 - link to the publication
  1. Apoptotic Regulatory Module as Switched Control System - Analysis of Asymptotic Properties
    Authors:
    Ochab M , Swierniak Andrzej , Klamka Jerzy , Puszynski Krzysztof
    Conference:
    the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) (rok: 2018, ), Wydawca: SCITEPRESS – Science and Technology Publications, Lda.
    Data:
    konferencja 19-21.01.2018
    Status:
    Published
  2. Correction of the genes expression measurements based on the probes design features.
    Authors:
    Krzysztof Puszynski ; Anna Lalik ; Roman Jaksik
    Conference:
    The 13th International Conference on Signal Processing and Communication Systems, ICSPCS'2019 (rok: 2019, ), Wydawca: IEEE
    Data:
    konferencja 43815
    Status:
    Published
  3. Influence of the Stochasticity in the Model on the Certain Drugs Pharmacodynamics
    Authors:
    Krzysztof Puszynski
    Conference:
    7th International Work-Conference, IWBBIO 2019 (rok: 2019, ), Wydawca: Springer Nature Switzerland AG 2019
    Data:
    konferencja 43593
    Status:
    Published
  1. System with switchings as models of regulatory modules in genomic cell systems
    Authors:
    Andrzej Swierniak, Magdalena Ochab, Krzysztof Puszynski
    Book:
    Studies in Systems, Decision and Control (rok: 2020, tom: 1, strony: 29), Wydawca: Springer
    Status:
    Published
  2. Układy sterowania z przełaczeniami jako modele modułów regulacyjnych w sieciach genowo-komórkowych
    Authors:
    Andrzej Swierniak, Magdalena Ochab, Krzysztof Puszynski
    Book:
    Automatyka, robotyka i przetwarzanie informacji (rok: 2019, tom: 1, strony: 31), Wydawca: PWN
    Status:
    Published
  3. Influence of the Number of Thresholds on the Dynamics of Models with Switchings of the Biological Systems
    Authors:
    Magdalena Ochab, Krzysztof Puszynski
    Book:
    Advanced, Contemporary Control (rok: 2020, tom: 1, strony: 587-598), Wydawca: Springer, Cham
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy