Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Changes in microRNA expression induced by homocysteine and homocysteine thiolactone

2016/23/N/NZ3/01216

Keywords:

protein N-homocysteinylation gene expression microRNA epigenetic modification

Descriptors:

  • NZ2_3: Proteomics
  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Łukasz Witucki 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2017-08-24

Project end date (Y-m-d): 2022-08-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (6)
  1. Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice
    Authors:
    Witucki Łukasz, Jakubowski Hieronim
    Academic press:
    The FASEB Journal (rok: 2024, tom: 38, strony: e70072), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202302116R - link to the publication
  2. Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease
    Authors:
    Witucki Ł, Krupik M, Jakubowski H, Szulc M, Mikołajczak PŁ, Jodynis-Liebert J, Kujawska M
    Academic press:
    Nutrients (rok: 2022, tom: 14, strony: 10), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu14102014. - link to the publication
  3. Homocysteine metabolites inhibit autophagy by upregulating miR-21-5p, miR-155-5p, miR-216-5p, and miR-320c-3p in human vascular endothelial cells
    Authors:
    Witucki Łukasz, Jakubowski Hieronim
    Academic press:
    Scientific reports (rok: 2024, tom: 14, strony: 7151), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-57750-3 - link to the publication
  1. Hyperhomocysteinemia and bleomycin hydrolase deficiency accelerate neurodegeneration by epigenetic dysregulation of mTOR signaling and inhibition of autophagy in mice
    Authors:
    Suszyńska-Zajczyk J.,Witucki Ł., Jacek Wróblewski J., Jakubowski H.
    Conference:
    EMBO Symposium: Probing neural dynamics with behavioural genetics. (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 43564
    Status:
    Published
  2. Hyperhomocysteinemia causes cognitive impairment by hyper-activating mTOR and impairing autophagy via the inhibition of Phf8 histone demethylase in mice
    Authors:
    Łukasz Witucki, Joanna Suszyńska-Zajczyk, Jacek Wróblewski, Robert K Filipkowski, Hieronim Jakubowski
    Conference:
    Fourth Annual Rutgers Brain Health Institute Symposium (rok: 2018, ), Wydawca: Rutgers Brain Health Institue Symposium
    Data:
    konferencja 30.11.2018
    Status:
    Published
  3. H4K20ME1-MEDIATED EPIGENETIC DYSREGULATION OF MTOR/AUTOPHAGY INCREASES AMYLOID BETA ACCUMULATION AND COGNITIVE/NEUROMOTOR DEFICITS IN HYPERHOMOCYSTEINEMIC AND BLEOMYCIN HYDROLASE-DEFICIENT MICE
    Authors:
    L. Witucki, J. Suszynska-Zajczyk, J. Wróblewski, H. Jakubowski
    Conference:
    16th International Conference on Alzheimer's and Parkinson's Diseases: Mechanisms, Clinical Strategies and promising Treatments of Neurodegenerative Diseases (rok: 2022, ), Wydawca: 16th International Conference on Alzheimer's and Parkinson's Diseases: Mechanisms, Clinical Strategies and promising Treatments of Neurodegenerative Diseases
    Data:
    konferencja 15-20.03
    Status:
    Published
  4. Epigenetic dysregulation of mTOR signaling and autophagy increases Aβ accumulation and cognitive deficits in hyperhomocysteinemia and bleomycin hydrolase deficient mice
    Authors:
    Witucki Ł., Suszyńska-Zajczyk J., Jacek Wróblewski J., Jakubowski H.
    Conference:
    Homocysteine Mini-Conference (rok: 2019, ), Wydawca: Homocysteine Mini-Conference,
    Data:
    konferencja 43734
    Status:
    Published
    DOI:
    link to the publication
  5. Silencing Cbs or Blmh gene promotes accumulation of amyloid beta via the Phf8/H4K20me1/mTOR/autophagy pathway in mouse neuroblastoma N2A- APPswe cells.
    Authors:
    Witucki Ł, Suszyńska-Zajczyk J, Jakubowski H.
    Conference:
    Homocysteine Mini-Conference Poznań (rok: 2020, ), Wydawca: Homocysteine Mini-Conference Poznań
    Data:
    konferencja 25.09.2020
    Status:
    Published
  6. Hyperhomocysteinemia causes cognitive impairment by hyper-activating mTOR and impairing autophagy via the inhibition of Phf8 histone demethylase in mice
    Authors:
    Łukasz Witucki, Joanna Suszyńska-Zajczyk, Jacek Wróblewski, Robert Filipkowski, Hieronim Jakubowski
    Conference:
    Folic Acid, Vitamin B12, and One-Carbon Metabolism (rok: 2018, ), Wydawca: FASEB
    Data:
    konferencja 29.07-03.08
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy