Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Influence of epigenetic factors on susceptibility to and clinical form of idiopathic scoliosis - analysis global DNA methylation and local CpG islands methylation of estrogen receptores type 1 and typ 2 genes and ladybird homeobox 1 gene

2016/23/D/NZ5/02606

Keywords:

idiopathic scoliosis IS AIS epigenetics DNA methylation CpG islands methylation estrogen receptor type 1 estrogen receptor type 2 ESR1 ESR2 ladybird homeobox 1 LBX1

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Janusz 

Number of co-investigators in the project: 4

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 765 500 PLN

Project start date (Y-m-d): 2017-07-17

Project end date (Y-m-d): 2022-07-16

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Pirosekwenator - PyroMark Q48 Autoprep Instrument (350 000 PLN)
  2. Laptop (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Methylation of Estrogen Receptor 1 Gene in the Paraspinal Muscles of Girls with Idiopathic Scoliosis and Its Association with Disease Severity
    Authors:
    Piotr Janusz, Małgorzata Chmielewska, Mirosław Andrusiewicz, Małgorzata Kotwicka, Tomasz Kotwicki
    Academic press:
    Genes (rok: 2021, tom: 21, strony: 790), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes12060790. - link to the publication
  2. Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis
    Authors:
    Małgorzata Chmielewska, Piotr Janusz, Mirosław Andrusiewicz, Tomasz Kotwicki, Małgorzata Kotwicka
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 22331), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-78454-4 - link to the publication
  3. Association of LBX1 Gene Methylation Level with Disease Severity in Patients with Idiopathic Scoliosis: Study on Deep Paravertebral Muscles
    Authors:
    Piotr Janusz, Małgorzata Tokłowicz, Mirosław Andrusiewicz, Małgorzata Kotwicka, Tomasz Kotwicki
    Academic press:
    Genes (rok: 2022, tom: 13, strony: 1556), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes13091556 - link to the publication

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