Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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A molecular analysis of the CRNDE gene and an attempt to assess the function and clinical significance of the newly discovered micropeptide encoded by this gene

2016/23/D/NZ5/01453

Keywords:

CRNDE prognostic marker micropeptide lncRNA oncogene

Descriptors:

  • NZ1_1: Molecular biology
  • NZ5_3: Pathogenesis of human diseases
  • NZ2_1: Molecular genetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łukasz Szafron 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 400 000 PLN

Project start date (Y-m-d): 2017-07-18

Project end date (Y-m-d): 2020-07-17

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zamrażarka niskotemperaturowa + mikroskop fluorescencyjny odwrócony.
  2. Inkubator z wytrząsaniem (Biogenet ES-20) (12 500 PLN)
  3. Mikroskop odwórcony (20 000 PLN)
  4. komora laminarna (28 000 PLN)
  5. Pipetor elektriniczny Swiftpet Pro (HTL) (1 000 PLN)
  6. hemocytometr (1 500 PLN)
  7. Inkubator komórek z kontrolą stężenia CO2 (37 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. PROM1, CXCL8, RUNX1, NAV1 and TP73 genes as independent markers predictive of prognosis or response to treatment in two cohorts of high-grade serous ovarian cancer patients
    Authors:
    Agnieszka Dansonka-Mieszkowska, Laura Aleksandra Szafron, Magdalena Kulesza, Anna Stachurska, Pawel Leszczynski, Agnieszka Tomczyk-Szatkowska, Piotr Sobiczewski, Joanna Parada, Mariusz Kulinczak, Joanna Moes-Sosnowska, Barbara Pienkowska-Grela, Jolanta Kupryjanczyk, Magdalena Chechlinska, Lukasz Michal Szafron
    Academic press:
    PLOS One (rok: 2022, tom: 17, strony: e0271539), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0271539 - link to the publication
  2. Multi-faceted analysis showing CRNDE gene, transcripts and the lately confirmed micropeptide as key players in ovarian carcinogenesis
    Authors:
    Anna Balcerak, Laura A. Szafron, Tymon Rubel, Bianka Swiderska, Arkadiusz Bonna, Roksana Iwanicka-Nowicka, Jolanta Kupryjanczyk, Lukasz M. Szafron
    Academic press:
    PLOS Medicine , Wydawca: PLOS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. The CRNDEP localization and interactions suggest its role in RNA metabolism, response to stress and cellular component organization
    Authors:
    Balcerak, A; Cysewski, D; Rubel, T; Grzybowska, E; Dansonka-Mieszkowska, A; Szafron, L
    Conference:
    43rd FEBS Congress, Biochemistry Forever (rok: 2018, ), Wydawca: WILEY
    Data:
    konferencja 7-12.07.2018
    Status:
    Published
  2. CRNDE is involved in the cell cycle progression, proliferation rate and microtubular cytoskeleton regulation.
    Authors:
    A. Balcerak, D. Cysewski, T. Rubel, E. Grzybowska, A. Dansonka-Mieszkowska, J. Kupryjanczyk, L. Szafron
    Conference:
    ASCB | EMBO 2018 Meeting (rok: 2018, ), Wydawca: Molecular Biology of the Cell
    Data:
    konferencja 08-12.12.2018
    Status:
    Accepted for publication

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