Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Cannabidiol as potential therapeutic agent for psoriasis and its role in the stabilization of physiological level of lipid mediators.

2016/23/B/NZ7/02350

Keywords:

psoriasis cannabidiol lipid mediators

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Skrzydlewska 

Number of co-investigators in the project: 18

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 447 468 PLN

Project start date (Y-m-d): 2017-08-03

Project end date (Y-m-d): 2021-08-02

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Pompa binarna UPLC (187 900 PLN)
  2. Automatyczny podajnik próbek UPLC (112 000 PLN)

Information in the final report

  • Publication in academic press/journals (26)
  1. Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis.
    Authors:
    Wójcik P., Biernacki M., Wroński A., Łuczaj W., Waeg G., Žarković N. Skrzydlewska E.
    Academic press:
    Int. J. Molec. Sci. (rok: 2019, tom: 20, strony: 4249), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20174249 - link to the publication
  2. Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris.
    Authors:
    Jarocka-Karpowicz I., Biernacki M., Wroński A., Gęgotek A., Skrzydlewska E.:
    Academic press:
    Biomolecules 2020, 10, 3, Article ID 367, 20 pp. doi:10.3390/biom10030367. (rok: 2020, tom: 10, strony: Article ID 367, 20 pp), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10030367 - link to the publication
  3. Effect of redox imbalance on protein modifications in lymphocytes of psoriatic patients.
    Authors:
    Wójcik P., Gęgotek A., Wroński A., Jastrząb A., Żebrowska A., Skrzydlewska E.
    Academic press:
    J. Biochem. 2020,167,323-331; doi:10.1093/jb/mvz096 (rok: 2020, tom: 167, strony: 323-331), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/jb/mvz096 - link to the publication
  4. Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol
    Authors:
    Michał Biernacki 1 , Małgorzata Michalina Brzóska 2 , Agnieszka Markowska 1 , Małgorzata Gała˙zyn-Sidorczuk 2, Bogdan Cylwik 3 , Agnieszka G˛egotek 1 and El˙zbieta Skrzydlewska
    Academic press:
    Antioxidants (rok: 2021, tom: 10, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10060821 - link to the publication
  5. Oxidative Stress and Lipid Mediators Modulate Immune Cell Functions in Autoimmune Diseases
    Authors:
    Piotr Wójcik 1 , Agnieszka G˛egotek 1, Neven Žarkovi´c 2 and El˙zbieta Skrzydlewska 1,*
    Academic press:
    IJMS (rok: 2021, tom: 22, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020723 - link to the publication
  6. Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients
    Authors:
    E. Ambrożewicz,1 P. Wojcik,1 A. Wroński,2 W. Luczaj,1 A. Jastrząb,1 N. Zarkovic,3 E.Skrzydlewska1*
    Academic press:
    Cells (rok: 2018, tom: 7(10), strony: 159), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells71001159 - link to the publication
  7. Therapeutic application of cannabidiol on UVA and UVB irradiated ratskin. A proteomic study
    Authors:
    Sinemyiz Atalaya, Agnieszka G˛egoteka, Adam Wro´nskib, Pedro Domiguesc,El˙zbieta Skrzydlewskaa,∗
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2021, tom: 192, strony: 45300), Wydawca: ELsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2020.113656 - link to the publication
  8. Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol
    Authors:
    W.Łuczaj, M.Rosário Domingues, P.Domingues, E.Skrzydlewska
    Academic press:
    Antioxidants (rok: 2020, tom: 9, strony: 1178), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9121178 - link to the publication
  9. Changes in the Physicochemical Properties of Blood and Skin Cell Membranes as a Result of Psoriasis Vulgaris and Psoriatic Arthritis Development
    Authors:
    Dobrzyńska I., Szachowicz-Petelska B., Wroński A., Jarocka-Karpowicz I., Skrzydlewska E.
    Academic press:
    IJMS (rok: 2020, tom: 21, strony: 9129), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239129 - link to the publication
  10. Reduced Proteasome Activity and Enhanced Autophagy in Blood Cells of Psoriatic Patients
    Authors:
    P.Karabowicz, A.Wronski, H.Ostrowska, G.Waeg, N.Zarkovic, E.Skrzydlewska
    Academic press:
    Int J Molec Sci (rok: 2020, tom: 21, strony: 7608), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21207608 - link to the publication
  11. Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients
    Authors:
    W.Łuczaj, I.Dobrzynska, A.Wronski, M.R.Domingues, P.Domingues, E.Skrzydlewska
    Academic press:
    Int.J.Mol.Sci. (rok: 2020, tom: 21, strony: 6592), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186592 - link to the publication
  12. Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol
    Authors:
    Wojciech Łuczaj 1,* , Anna Jastrza˛b 1 , Maria do Rosário Domingues 2,3 , Pedro Domingues 2 and El˙zbieta Skrzydlewska
    Academic press:
    IJMS (rok: 2021, tom: 22, strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22168700 - link to the publication
  13. The differences in proteome profile of cannabidiol treated skin fibroblasts following UVA or UVB irradiation in 2D and 3D cell cultures
    Authors:
    Gęgotek A., Atalay S., , Domingues P., Skrzydlewska
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 995), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8090995 - link to the publication
  14. The proteomic profile of keratinocytes and lymphocytes in psoriatic patients
    Authors:
    Agnieszka Gęgotek1, Pedro Domingues2, Adam Wroński3, Ewa Ambrożewicz1, Elżbieta Skrzydlewska1*
    Academic press:
    Proteomic Clinical Application (rok: 2019, tom: 1800119, strony: 1800119), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/prca.201800119 - link to the publication
  15. Antioxidant and Anti-inflammatory Effect of Cannabidiol Contributes to the Decreased Lipid Peroxidation of Keratinocytes of Rat Skin Exposed to UV Radiation
    Authors:
    Anna Jastrząb,1 Iwona Jarocka-Karpowicz,1 Agnieszka Markowska,1 Adam Wroński,2 Agnieszka Gęgotek ,1 and Elżbieta Skrzydlewska
    Academic press:
    Hindawi Oxidative Medicine and Cellular Longevity (rok: 2021, tom: 2021, strony: 13), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/6647222 - link to the publication
  16. Cannabidiol decreases metalloproteinase activity and normalizes angiogenesis factor expression in UVB-irradiated keratinocytes from psoriatic patients
    Authors:
    Gęgotek A., Atalay S., Wroński A., Markowska A., Skrzydlewska E
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2021, tom: 11, strony: Article ID 7624389, 11 pages), Wydawca: HIndawi
    Status:
    Published
    DOI:
    10.3390/ijms22168700 - link to the publication
  17. Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation.
    Authors:
    Jastrząb A., Gęgotek A., Skrzydlewska E.
    Academic press:
    Cells, (rok: 2019, tom: 8, strony: 827), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8080827 - link to the publication
  18. Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions
    Authors:
    A.Gęgotek, P.Domingues, A.Wroński E.Skrzydlewska
    Academic press:
    Int J Molec Sci (rok: 2020, tom: 21, strony: 5363), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21155363 - link to the publication
  19. Disease-Dependent Antiapoptotic Effects of Cannabidiol for Keratinocytes Observed upon UV Irradiation
    Authors:
    Piotr Wójcik 1 , Agnieszka G˛egotek 1 , Neven Žarkovi´c 2 and El˙zbieta Skrzydlewska
    Academic press:
    IJMS (rok: 2021, tom: 22, strony: 45310), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189956 - link to the publication
  20. Lipidomic Analysis Reveals Specific Differences between Fibroblast and Keratinocyte Ceramide Profile of Patients with Psoriasis Vulgaris
    Authors:
    Łuczaj W., Wroński A., Domingues P., Domingues M.R., Skrzydlewska E.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: Article ID 630, 14 pp), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25030630 - link to the publication
  21. Proteomic plasma profile of psoriatic patients
    Authors:
    Agnieszka Gęgotek, Pedro Domingues, Adam Wroński, Piotr Wojcik, Elżbieta Skrzydlewska1*
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2018, tom: 155, strony: 185-193), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2018.03.068 - link to the publication
  22. UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol.
    Authors:
    Gęgotek A., Atalay S., Skrzydlewska E.
    Academic press:
    Sci.Reports 11 (2021) 20666. https://doi.org/10.1038/s41598-021-00134-8 (rok: 2021, tom: 11, strony: 13, 20666), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-00134-8 - link to the publication
  23. Analytical approaches to assess metabolic changes in psoriasis
    Authors:
    Wojciech Łuczaj, Agnieszka Gęgotek, Elżbieta Skrzydlewska
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis 205 (2021) 11435 (rok: 2021, tom: 205, strony: 45308), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2021.114359 - link to the publication
  24. Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients
    Authors:
    P.Wójcik, M.Garley, A.Wronski, E.Jabłonska, E. Skrzydlewska
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 6795), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186795 - link to the publication
  25. Changes in Hepatic Phospholipid Metabolism in Rats under UV Irradiation and Topically Treated with Cannabidiol
    Authors:
    Michał Biernacki , Anna Jastrza˛b and Elz˙bieta Skrzydlewska
    Academic press:
    Antioxidants (rok: 2021, tom: 10,, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10081157 - link to the publication
  26. The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People
    Authors:
    Barbara Szachowicz-Petelska 1, Wojciech Łuczaj 2, Adam Wroński 3, Anna Jastrząb 2 and Izabela Dobrzyńska 1,*
    Academic press:
    Membranes (rok: 2021, tom: 11, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11020111 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy