Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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NK cells with inducible expression of CAR as novel immunotherapy increasing the efficacy of monoclonal antibodies.

2016/23/B/NZ5/02622

Keywords:

NK cells chimeric antigen receptors anti-CD20 therapeutic antibodies

Descriptors:

  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Beata Pyrzyńska 

Number of co-investigators in the project: 4

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 651 770 PLN

Project start date (Y-m-d): 2017-08-01

Project end date (Y-m-d): 2022-07-31

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. CAR-NK as a Rapidly Developed and Efficient Immunotherapeutic Strategy Against Cancer.
    Authors:
    Włodarczyk M, Pyrzyńska B.
    Academic press:
    Cancers (rok: 2023, tom: 15(1), strony: 117-132), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15010117 - link to the publication
  2. NK Cell Degranulation Triggered by Rituximab Identifies Potential Markers of Subpopulations with Enhanced Cytotoxicity toward Malignant B Cells.
    Authors:
    Wlodarczyk M., Torun A., Zerrouqi A., Pyrzynska B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 8980), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25168980 - link to the publication
  3. Potassium/sodium cation carriers robustly upregulate CD20 antigen by targeting MYC and synergize with anti-CD20 immunotherapies to eliminate malignant B cells.
    Authors:
    Torun A., Zdanowicz A., Miazek-Zapala N., Zapala P., Jedrzejczyk M., Ciechanowicz A., Pilch Z., Pradhan B., Skorzynski M., Mikołaj Słabicki4, Grzegorz Rymkiewicz5, Joanna Barankiewicz , Martines C., Laurenti L., Struga M., Winiarska M., Golab J., Kucia M., Ratajczak M.Z., Huczynski A., Calado D.P., Efremov D.G, Zerrouqi A., Pyrzynska B.
    Academic press:
    Haematologica (rok: 2024, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Ferrata-Storti Foundation
    Status:
    Submitted
    DOI:
    nie - link to the publication
  1. Natural killer immune response is promoted by the treatment of B-cell lymphoma cancer cells with membrane ionophores.
    Authors:
    Zerrouqi A., Torun A., Miazek N., Pilch Z., Golab J., Pyrzynska B.
    Conference:
    AACR Special Conference on Tumor Immunology and Immunotherapy, Boston, MA, USA (rok: 2020, ), Wydawca: AACR
    Data:
    konferencja 43786
    Status:
    Published
  2. Salinomycin expands the cytotoxicity of both anti-CD20 monoclonal antibodies and natural killer cells towards non-Hodgkin lymphomas.
    Authors:
    Zerrouqi A., Miazek-Zapala N., Torun A., Zapala P., Golab J., Winiarska M., Pyrzynska B.
    Conference:
    Annual Meeting of the American Association for Cancer Research (AACR), Atlanta, GA, USA (rok: 2019, ), Wydawca: AACR
    Data:
    konferencja 43553
    Status:
    Published

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