Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Biological response induced by high antitumor active unsymmetrical bisacridines against human colon and lung cancers and improved by nanoparticles drug delivery.

2016/23/B/NZ7/03324

Keywords:

unsymmetrical bisacridines antitumor activity cellular response nanoparticles coniugated with bisacridines,

Descriptors:

  • NZ3_1: Cell biology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewa Augustin 

Number of co-investigators in the project: 7

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 343 220 PLN

Project start date (Y-m-d): 2017-10-02

Project end date (Y-m-d): 2021-07-01

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. termobloki.
  2. chłodziarka laboratoryjna.
  3. Pompa do odsysania pożywek (ssak medyczny) (3 600 PLN)
  4. laptop.
  5. Łaźnia ultradźwiękowa. (8 000 PLN)
  6. Spektrofotometr NanoDrop One (61 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (8)
  1. Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells.
    Authors:
    Pilch J., Kowalik P., Bujak P., Nowicka A. M., Augustin E.
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano11020462 - link to the publication
  2. Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA Gquadruplexes
    Authors:
    Ewa Paluszkiewicz, Barbara Horowska, Barbara Borowa-Mazgaj, Grażyna Peszyńska-Sularz, Jolanta Paradziej-Łukowicz, Ewa Augustin, Jerzy Konopa, Zofia Mazerska
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2020, tom: 204, strony: 112599), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2020.112599 - link to the publication
  3. The influence of antitumor unsymmetrical bisacridines on 3D cancer spheroids growth and viability
    Authors:
    Jolanta Kulesza, Monika Pawłowska, Ewa Augustin
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 6262), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26206262 - link to the publication
  4. New Unsymmetrical Bisacridine Derivatives Noncovalently Attached to Quaternary Quantum Dots Improve Cancer Therapy by Enhancing Cytotoxicity toward Cancer Cells and Protecting Normal Cells
    Authors:
    Joanna Pilch, Edyta Matysiak-Brynda, Agata Kowalczyk, Piotr Bujak, Zofia Mazerska, Anna M. Nowicka and Ewa Augustin
    Academic press:
    ACS Applied Materials & Interfaces (rok: 2020, tom: 12, strony: 17276-17289), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsami.0c02621 - link to the publication
  1. New antitumor unsymmetrical bisacridines derivatives affect cmyc and KRas level leading to cell death and accelerated senescence in human lung and colon cancer cells
    Authors:
    Monika Pawłowska, Jolanta Kulesza, Zofia Mazerska, Ewa Augustin
    Conference:
    The 45th FEBS Virtual Congress, Lubljana, Slovenia. Molecules for life: Towards New Horizons (rok: 2021, ), Wydawca: FEBS
    Data:
    konferencja 03-08.07.2021
    Status:
    Published
  2. The impact of pH-dependent quantum dots-unsymmetrical bisacridine nanoconjugates on the lysosomal content and the cytotoxicity in lung and colon cancer cells as well as in normal cells.
    Authors:
    Pilch J., Bujak P., Kowalczyk A., Nowicka A. M., Augustin E
    Conference:
    The 41st EORTC-PAMM Winter Meeting. (rok: 2020, ), Wydawca: PAMM
    Data:
    konferencja 13-15.02.2020
    Status:
    Published
  3. Quntum dots conjugates with unsymmetrical bisacridines enhance cytotoxicity of these antitumor compounds in lung cancer cells and have protecting effects on normal cells.
    Authors:
    Pilch J, Pawłowska M, Bujak P, Nowicka A, Augustin E
    Conference:
    30th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Irleand (rok: 2018, ), Wydawca: European Journal of Cancer, Supplement Elsevier
    Data:
    konferencja 13-16.11.2018
    Status:
    Published
  4. Effects of unsymmetrical bisacridines on the spherical culture system of HCT116 colon and H460 lung cancer cell lines.
    Authors:
    Jolanta Kulesza, Monika Pawłowska, Ewa Augustin
    Conference:
    The 45th FEBS Virtual Congress, Lubljana, Slovenia. Molecules of life: Towards New Horizons (rok: 2021, ), Wydawca: FEBS
    Data:
    konferencja 03-08.07.2021
    Status:
    Published
  5. The cellular rsponse of human colon and lung cancer cells to tratment with unsymmetrical bisacridine derivatives.
    Authors:
    Milena Gospodarek, Monika Pawłowska, Ewa Augustin
    Conference:
    Kongres BIO2018 (rok: 2018, ), Wydawca: Acta Biochimica Polonica, vol. 65, suppl. 2, 2018
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  6. The influence of quantum dots Ag-In-Zn-S conjugated with unsymmetrical bisacridine derivatives on cytotoxicity and cell cycle distribution in lung and colon cancer cells.
    Authors:
    Joanna Pilch, Piotr Bujak, Anna M. Nowicka, Ewa Augustin
    Conference:
    Kongres BIO2018 (rok: 2018, ), Wydawca: Acta Biochimica Polonica, vol.65, suppl.2 , 2018
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  7. Comparison of cellular response induce by unsymmetrical bisacridine derivative, C-2045 and its monomer subunit, C-1311 in HCT116 and H460 cancer cells.
    Authors:
    Monika Pawłowska, Małgorzata Górczak, Sylwia Ossowska, Joanna Polewska, Ewa Augustin
    Conference:
    Kongres BIO2018 (rok: 2018, ), Wydawca: Acta Biochmica Polonica, vol. 65, suppl. 2, 2018
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  8. The conjugation of antitumor unsymmetrical bisacridines with quantum dots enhance cytotoxicity and change the biological response in lung and colon cancer cells
    Authors:
    Joanna Pilch, Piotr Bujak, Anna M. Nowicka, Ewa Augustin
    Conference:
    The 45th FEBS Virtual Congress, Lublajana, Slovenia. Molecules for life: Towards New Horizons (rok: 2021, ), Wydawca: FEBS
    Data:
    konferencja 03-08.07.2021
    Status:
    Published

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