Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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New strategies in cancer therapy - bioinorganic conjugates of cytostatics and boron clusters.

2016/23/D/NZ1/02611

Keywords:

boron clusters hybride molecules boron neutron capture therapy (BNCT)

Descriptors:

  • NZ1_9: Biotechnology
  • NZ1_11: Other related subjects

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Goszczyński 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 759 980 PLN

Project start date (Y-m-d): 2017-09-14

Project end date (Y-m-d): 2021-07-13

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Icosahedral boron clusters as modifying entities for biomolecules
    Authors:
    Goszczynski, T. M., Fink, K., and Boratynski, J.
    Academic press:
    Expert Opinion on Biological Therapy (rok: 2018, tom: 18, strony: 205-213), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14712598.2018.1473369 - link to the publication
  2. Metallacarborane Derivatives Effective against Pseudomonas aeruginosa and Yersinia enterocolitica.
    Authors:
    Swietnicki, W., Goldeman, W., Psurski, M., Nasulewicz-Goldeman, A., Boguszewska-Czubara, A., Drab, M., Sycz, J., and Goszczyński, T. M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, 6762, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136762 - link to the publication
  3. Synthesis and Biological Activity of Thymosin β4-Anionic Boron Cluster Conjugates
    Authors:
    Fink, K., Kobak, K., Kasztura, M., Boratyński, J., and Goszczyński, T. M.
    Academic press:
    Bioconjugate Chemistry (rok: 2018, tom: 29, strony: 3509-3515), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.8b00646 - link to the publication
  4. Metallacarborane Derivatives as Innovative Anti-Candida albicans Agents.
    Authors:
    Kubinski, K.; Maslyk, M.; Janeczko, M.; Goldeman, W.; Nasulewicz-Goldeman, A.; Psurski, M.; Martyna, A.; Boguszewska-Czubara, A.; Cebula, J.; Goszczynski, T.M.
    Academic press:
    Journal of Medicinal Chemistry (rok: 2022, tom: 65, strony: 13935-13945), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.2c01167 - link to the publication
  5. Metallacarboranes as a tool for enhancing the activity of therapeutic peptides
    Authors:
    Fink, K., Boratynski, J., Paprocka, M., and Goszczynski, T. M.
    Academic press:
    Annals of the New York Academy of Sciences (rok: 2019, tom: 1457, strony: 128-141), Wydawca: John Wiley & Sons, Inc.
    Status:
    Published
    DOI:
    10.1111/nyas.14201 - link to the publication

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