Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of neurotrophins and angiogenic cytokines in the pathophysiology of treatment-induced peripheral neuropathy in patients with multiple myeloma

2016/23/B/NZ7/03363

Keywords:

multiple myeloma neuropathy neurotrophins angiogenic factors

Descriptors:

  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Medycyny i Stomatologii

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bogusław Machaliński 

Number of co-investigators in the project: 4

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 124 900 PLN

Project start date (Y-m-d): 2017-08-04

Project end date (Y-m-d): 2021-02-03

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. 6-kanałowy system do detekcji PCR w czasie rzeczywistym.
  2. Aparat do separacji immunomagnetycznej autoMACS® Pro Separator (Miltenyi Biotec) (250 000 PLN)
  3. Podstawa termocyklera c1000.
  4. Wielomodułowy czytnik mikropłytek.

Information in the final report

  • Publication in academic press/journals (8)
  1. Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
    Authors:
    Łuczkowska K, Sokolowska KE, Taryma-Lesniak O, Pastuszak K, Supernat A, Bybjerg-Grauholm J, Hansen LL, Paczkowska E, Wojdacz TK, Machaliński B
    Academic press:
    Scientific Reports (rok: 2021, tom: 10;11(1), strony: 9846), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-89128-0 - link to the publication
  2. Bortezomib-Induced Epigenetic Alterations in Nerve Cells: Focus on the Mechanisms Contributing to the Peripheral Neuropathy Development
    Authors:
    Karolina Łuczkowska, Dorota Rogińska, Piotr Kulig, Anna Bielikowicz, Bartłomiej Baumert, Bogusław Machaliński.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 2431), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052431 - link to the publication
  3. The Potential Role of Proinflammatory Cytokines and Complement Components in the Development of Drug-Induced Neuropathy in Patients with Multiple Myeloma
    Authors:
    Łuczkowska K, Rutka M, Rogińska D, Paczkowska E, Baumert B, Milczarek S, Górska M, Kulig P, Osękowska B, Janowski M, Safranow K, Sommerfeld K, Borowiecka E, Zawodny P, Koclęga A, Helbig G, Machaliński B.
    Academic press:
    Journal of Clinical Medicine (rok: 2021, tom: 4;10(19), strony: 4584), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm10194584 - link to the publication
  4. microRNAs as the biomarkers of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma.
    Authors:
    Łuczkowska K, Rogińska D, Ulańczyk Z, Safranow K, Paczkowska E, Baumert B, Milczarek S, Osękowska B, Górska M, Borowiecka E, Sommerfeld K, Zawodny P, Szudy-Szczyrek A, Hus M, Machaliński B
    Academic press:
    Leukemia & Lymphoma (rok: 2021, tom: 62(11), strony: 2768-2776), Wydawca: TAYLOR & FRANCIS LTD
    Status:
    Published
    DOI:
    10.1080/10428194.2021.1933478 - link to the publication
  5. Molecular Mechanisms of Bortezomib Action: Novel Evidence for the miRNA-mRNA Interaction Involvement
    Authors:
    Karolina Łuczkowska , Dorota Rogińska , Zofia Ulańczyk , Edyta Paczkowska , Christian Andreas Schmidt , Bogusław Machaliński
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 5;21(1), strony: 350), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21010350. - link to the publication
  6. Pathophysiology of drug-induce peripheral neuropathy in patients with multiple myeloma.
    Authors:
    Luczkowska K, Litwinska Z, Paczkowska E, Machalinski B
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2018, tom: 69(2), strony: 165-172), Wydawca: JAGIELLONIAN UNIV SCHOOL MED
    Status:
    Published
    DOI:
    10.26402/jpp.2018.2.02 - link to the publication
  7. Effect of Bortezomib on Global Gene Expression in PC12-Derived Nerve Cells
    Authors:
    Karolina Łuczkowska, Dorota Rogińska, Zofia Ulańczyk, Bogusław Machaliński
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 23;21(3), strony: 751), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21030751 - link to the publication
  8. Peripheral neuropathy in patients with multiple myeloma: molecular effects of bortezomib
    Authors:
    Karolina Łuczkowska, Bogusław Machaliński
    Academic press:
    Acta Haematologica Polonica (rok: 2021, tom: 4 (52), strony: 375–381), Wydawca: VIA Medica Journal
    Status:
    Published
    DOI:
    0.5603/AHP.2021.0071 - link to the publication

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