Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Spectral histopathology, FTIR and immunoSERS, for the recognition of biochemical status of pre-metastatic niche and micrometastasis in murine model of breast cancer

2016/23/B/NZ4/01379

Keywords:

cancer micrometastasis murine breast cancer model spectral histopathology FTIR spectroscopy SERS spectroscopy

Descriptors:

  • ST4_3: Molecular architecture and structure
  • NZ4_5: Anatomical pathology
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Kamilla Małek 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 011 050 PLN

Project start date (Y-m-d): 2017-08-04

Project end date (Y-m-d): 2022-02-03

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer (10 000 PLN)
  2. Laptop 2 szt..
  3. Rotator (4 000 PLN)
  4. Wytrząsarka.
  5. Elementy optyczne, elektroniczne i mechaniczne do spektrometrów IR i ramanowskiego (2 szt.) (15 000 PLN)
  6. Licencja Microsoft Office.
  7. dyski przenośne 4 szt..
  8. Elementy optyczne, elektroniczne i mechaniczne do spektrometrów IR i ramanowskiego (4 szt.) (32 000 PLN)
  9. Komputer stacjonarny.
  10. Kontaktowy kontroler temperatury (3 000 PLN)
  11. Licencja programu SOLO+MIA (5 497 PLN)
  12. Rzutnik multimedialny.
  13. Skaner wiązki laserowej.
  14. Wirówka laboratoryjna z regulacją temperatury (20 000 PLN)
  15. laser do spektrometru ramanowskiego (120 000 PLN)
  16. przenośne dyski o pojemności > 1 TB (2 szt.) (1 200 PLN)
  17. Obiektyw o powiększeniu 25x do mikroskopu FTIR Agilent model 670 (60 000 PLN)
  18. Oprogramowanie specjalistyczne (3 szt.) (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Book publications / chapters in book publications (1)
  1. Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs
    Authors:
    A. Blat, E. Wiercigroch, M. Smeda, A. Wislocka,S. Chlopicki, K. Malek
    Academic press:
    Journal of Biophotonics (rok: 2019, tom: 12, strony: 45302), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jbio.201900067 - link to the publication
  2. Label-free FTIR spectroscopy detects and visualizes the early stage of pulmonary micrometastasis seeded from breast carcinoma
    Authors:
    Karolina Chrabaszcz, Agnieszka Jasztal, Marta Smęda, Bartosz Zieliński, Aneta Blat, Max Diem, Stefan Chlopicki, Kamilla Malek, Katarzyna M. Marzec
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2018, tom: 1864, strony: 3574-3584), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2018.08.022 - link to the publication
  3. Fourier Transform Infrared Polarization Contrast Imaging Recognizes Proteins Degradation in Lungs upon Metastasis from Breast Cancer
    Authors:
    K. Chrabaszcz, K. Kaminska, C.L. Song, J. Morikawa, M. Kujdowicz, E. Michalczyk, M. Smeda, M. Stojak, A. Jasztal, S.G. Kazarian, K. Malek
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13020162 - link to the publication
  4. Tracking extracellular matrix remodeling in lungs induced by breast cancer metastasis. Fourier Transform Infrared spectroscopic studies
    Authors:
    K. Chrabaszcz, K. Kaminska, K. Augustyniak, M. Kujdowicz, M. Smeda, A. Jasztal, M. Stojak, K.M. Marzec, K. Malek
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25010236 - link to the publication
  5. High-Resolution Fourier Transform Infrared (FT-IR) Spectroscopic Imaging for Detection of Lung Structures and Cancer-Related Abnormalities in a Murine Model
    Authors:
    Karolina Augustyniak, Karolina Chrabaszcz, Marta Smeda, Marta Stojak, Katarzyna M. Marzec, Kamilla Malek
    Academic press:
    Applied Spectroscopy (rok: 2021, ), Wydawca: SAGE journals
    Status:
    Published
    DOI:
    10.1177/00037028211025540 - link to the publication
  6. High and ultra-high definition of infrared spectral histopathologygives an insight into chemical environment of lung metastases inbreast cancer
    Authors:
    Karolina Augustyniak, Karolina Chrabaszcz, Agnieszka Jasztal, Marta Smeda, Guillermo Quintas, Julia Kuligowska, Katarzyna M. Marzec, Kamilla Malek
    Academic press:
    Journal of Biophotonics (rok: 2019, tom: e201800345, strony: 45299), Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    10.1002/jbio.201800345 - link to the publication
  7. Molecular profiling of the intestinal mucosa and immune cells of the colon by multi-parametric histological techniques
    Authors:
    Łukasz Zadka, Karolina Chrabaszcz, Igor Buzalewicz, Ewelina Wiercigroch, Natalia Glatzel-Plucińska, Łukasz Szleszkowski, Agnieszka Gomułkiewicz, Aleksandra Piotrowska, Krzysztof Kurnol, Piotr Dzięgiel, Tomasz Jurek, Kamilla Malek
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 45307), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-90761-y - link to the publication
  8. Multimodal vibrational studies of drug uptake in vitro: Is the whole greater than the sum of their parts?
    Authors:
    David Perez‐Guaita, Karolina Chrabaszcz, Kamilla Malek, Hugh J. Byrne
    Academic press:
    Journal of Biophotonics (rok: 2020, tom: 13, strony: e202000264), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jbio.202000264 - link to the publication
  1. Vibrational imaging of proteins: changes in the tissues and cells in the lifestyle disease studies
    Authors:
    K. Majzner, K. Czamara, M.Z. Pacia, J. Dybaś, E. Bik, K. Chrąbaszcz, E. Bik, K. Chrabąszcz, E. Wiercigroch, A. Dorosz, A. Wisłocka, K. M. Marzec, K. Małek, M. Barańska
    Book:
    Vibrational Spectroscopy in Protein Research (rok: 2020, tom: 1, strony: 177-218), Wydawca: Elsevier
    Status:
    Published