Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Impact of hypoxia on molecular characteristic and biological properties, including heart regenerative capacity of extracellular vesicles released by human induced pluripotent stem cells

2016/23/D/NZ3/01310

Keywords:

extracellular vesicles hypoxia induced pluripotent stem cells heart regeneration

Descriptors:

  • NZ3_8: Stem cell biology
  • NZ1_1: Molecular biology
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sylwia Bobis-Wozowicz 

Number of co-investigators in the project: 6

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 967 750 PLN

Project start date (Y-m-d): 2017-07-19

Project end date (Y-m-d): 2022-07-18

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Hypoxic extracellular vesicles from hiPSCs protect cardiomyocytes from oxidative damage by transferring antioxidant proteins and enhancing Akt/Erk/NRF2 signaling
    Authors:
    Sylwia Bobis-Wozowicz, Milena Paw, Michał Sarna, Sylwia Kędracka-Krok, Kinga Nit, Natalia Błażowska, Anna Dobosz, Ruba Hammad, Toni Cathomen, Ewa Zuba-Surma, Małgorzata Tyszka-Czochara, Zbigniew Madeja.
    Academic press:
    Cell Communication and Signaling , Wydawca: BioMed Central
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFb/SMAD2 axis
    Authors:
    Milena Paw, Agnieszka A Kusiak, Kinga Nit, Jacek J Litewka, Marcin Piejko, Dawid Wnuk, Michał Sarna, Kinga Fic, Kinga B Stopa, Ruba Hammad, Olga Barczyk-Woznicka, Toni Cathomen, Ewa Zuba-Surma, Zbigniew Madeja, Paweł E Ferdek, Sylwia Bobis-Wozowicz
    Academic press:
    BMC Medicine (rok: 2023, tom: 21, strony: 412), Wydawca: Bio Med Central
    Status:
    Published
    DOI:
    10.1186/s12916-023-03117-w. - link to the publication
  3. Editorial: Extracellular Vesicles as Next Generation Therapeutics.
    Authors:
    Bobis-Wozowicz S, Marbán E.
    Academic press:
    Front Cell Dev Biol. (rok: 2022, tom: 10, strony: 919426), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fcell.2022.919426 - link to the publication
  4. Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism.
    Authors:
    Nit K, Tyszka-Czochara M, Bobis-Wozowicz S.
    Academic press:
    J Pers Med. (rok: 2021, tom: 11, strony: 905), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jpm11090905 - link to the publication
  5. SB203580-A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma.
    Authors:
    Paw M, Wnuk D, Nit K, Bobis-Wozowicz S, Szychowski R, Ślusarczyk A, Madeja Z, Michalik M.
    Academic press:
    Int J Mol Sci. (rok: 2021, tom: 22, strony: 12790), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222312790 - link to the publication
  1. Antifibrotic properties of extracellular vesicles derived from human induced pluripotent stem cells
    Authors:
    Milena Paw, Kinga Polańska, Marcin Piejko, Sylwia Kedracka-Krok, Ruba Hammad, Dawid Wnuk, Toni Cathomen, Zbigniew Madeja, Ewa Zuba-Surma, Sylwia Bobis-Wozowicz
    Conference:
    International Society for Extracellular Vesicles Annual Meeting 2020 (rok: 2020, ), Wydawca: Taylor & Francis Group
    Data:
    konferencja 20-22.07.2020r.
    Status:
    Published
  2. Hypoxic extracellular vesicles protect human cardiomyocytes from oxidative damage
    Authors:
    Sylwia Bobis-Wozowicz, Natalia Błażowska, Milena Paw, Sylwia Kędracka-Krok, Ruba Hammad, Kinga Nit, Toni Cathomen, Zbigniew Madeja
    Conference:
    European Society for Cell and Gene Therapy (ESGCT) Collaborative Virtual Congress (rok: 2021, ), Wydawca: Mary Ann Liebert
    Data:
    konferencja 19-22.10.2021
    Status:
    Published

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