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Information on the principal investigator and host institution

Information of the project and the call

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Studies on the 2-thiouridine tRNA damage induced in the cells under oxidative stress

2016/23/B/NZ1/02316

Keywords:

2-thiouridine tRNA Oxidative stress Reactive oxigen species ROS desulfuration 4-pyrimidinone

Descriptors:

  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Sierant 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 846 010 PLN

Project start date (Y-m-d): 2017-09-28

Project end date (Y-m-d): 2022-09-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (3)
  • Book publications / chapters in book publications (1)
  1. Studies on the Oxidative Damage of the Wobble 5-Methylcarboxymethyl-2-Thiouridine in the tRNA of Eukaryotic Cells with Disturbed Homeostasis of the Antioxidant System
    Authors:
    Malgorzata Sierant*, Rafal Szewczyk, Agnieszka Dziergowska, Karolina Krolewska-Golinska, Patrycja Szczupak, Przemyslaw Bernat and Barbara Nawrot
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25(22), strony: 12336), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms252212336 - link to the publication
  1. Studies on the 2-thiouridine-tRNA damage induced in the Saccharomyces cerevisiae yeast cells under oxidative stress conditions.
    Authors:
    M. Sierant, R. Szewczyk, A. Dziergowska, K. Krolewska-Golinska, E. Sochacka, B. Nawrot.
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS PRESS
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  2. Intracellular damage of mcm5S2U-tRNA induced by oxidative stress.
    Authors:
    M. Sierant, R. Szewczyk, K. Krolewska-Golinska, A. Dziergowska, P. Bernat, E. Sochacka, B. Nawrot.
    Conference:
    45th FEBS Congress (rok: 2021, ), Wydawca: FEBS PRESS
    Data:
    konferencja 3-8 lipca
    Status:
    Published
  3. Studies on the oxidative damage of wobble 5-methylcarboxymethyl- 2-thiouridine in transfer RNAs
    Authors:
    Malgorzata Sierant, Patrycja Komar, Rafal Szewczyk, Agnieszka Dziergowska, Elżbieta Sochacka, Barbara Nawrot
    Conference:
    Congress BIO2018 (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21 wrzesień 2018
    Status:
    Published
  1. Sulfur and Selenium modified bacterial tRNAs
    Authors:
    Nawrot Barbara, Sierant Małgorzata, Szczupak Patrycja
    Book:
    Handbook of Chemical Biology of Nucleic Acids (rok: 2023, tom: Nucleic Acids and Gene Expression, strony: 1231-1264), Wydawca: Springer Nature
    Status:
    Published

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