Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The second life of salinomycin: Chemo- and regioselective modifications of salinomycin and their influence on the anti-cancer and anti-microbial activity

2016/23/D/ST5/00242

Keywords:

Ionophores synthesis anticancer activity antimicrobial activity

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Antoszczak 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 726 338 PLN

Project start date (Y-m-d): 2017-07-11

Project end date (Y-m-d): 2020-07-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer typu notebook (6 000 PLN)
  2. Waga laboratoryjna (8 000 PLN)
  3. Laboratoryjna pompa strzykawkowa (15 000 PLN)
  4. System do chromatografii typu FLASH i preparatywnej z detektorami UV oraz ELSD (300 000 PLN)
  5. Łaźnia (myjka) ultradźwiękowa (9 000 PLN)
  6. Kolumny do HPLC z wypełnieniem chiralnym (10 000 PLN)
  7. Modułowy, wielostanowiskowy system do syntezy równoległej (50 000 PLN)
  8. Kolumny do HPLC (analityczne i preparatywne) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (1)
  • Book publications / chapters in book publications (1)
  1. Synteza i aktywność biologiczna pochodnych salinomycyny
    Authors:
    M. Antoszczak*, A. Huczyński, B. Brzezinski
    Academic press:
    Wiadomości Chemiczne (rok: 2017, tom: 71, strony: 629-661), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Biokoniugaty antybiotyków jonoforowych - Cele, strategie syntezy i właściwości
    Authors:
    M. Antoszczak*, M. Kordylas, A. Huczyński
    Academic press:
    Wiadomości Chemiczne (rok: 2018, tom: 72, strony: 45319), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo
    Authors:
    M. Antoszczak*, A. Urbaniak, M. Delgado, E. Maj, B. Borgstrom, J. Wietrzyk, A. Huczyński, Y. Yuan, T.C. Chambers, D. Strand
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2018, tom: 156, strony: 510-523), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.07.021 - link to the publication
  4. Synthesis and anticancer activity of dimeric polyether ionophores
    Authors:
    M. Sulik, E. Maj, J. Wietrzyk, A. Huczyński, M. Antoszczak*
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 1039), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10071039 - link to the publication
  5. Synthesis and anticancer activity of tertiary amides of salinomycin and their C20-oxo analogues
    Authors:
    D. Czerwonka, A. Urbaniak, S. Sobczak, S. Piña-Oviedo, T.C. Chambers, M. Antoszczak*, A. Huczyński
    Academic press:
    ChemMedChem (rok: 2020, tom: 15, strony: 236-246), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cmdc.201900593 - link to the publication
  6. A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents
    Authors:
    M. Antoszczak*
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 166, strony: 48-64), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.01.034 - link to the publication
  7. Anti-trypanosomal activity of doubly modified salinomycin derivatives
    Authors:
    M. Antoszczak*, D. Steverding, M. Sulik, J. Janczak, A. Huczyński
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 173, strony: 90-98), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.03.061 - link to the publication
  8. Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro
    Authors:
    A. Urbaniak, M. Delgado, M. Antoszczak, A. Huczyński, T.C. Chambers
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2018, tom: 99, strony: 384-390), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2018.01.081 - link to the publication
  9. A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
    Authors:
    M. Antoszczak*
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 164, strony: 366-377), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.12.057 - link to the publication
  10. Anti-parasitic activity of polyether ionophores
    Authors:
    M. Antoszczak, D. Steverding, A. Huczyński
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 166, strony: 32-47), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.01.035 - link to the publication
  11. Antibacterial activity of singly and doubly modified salinomycin derivatives
    Authors:
    M. Sulik, K. Stępień, J. Stefańska, A. Huczyński, M. Antoszczak*
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2020, tom: 30, strony: 127062), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2020.127062 - link to the publication
  12. Overcoming resistance to platinum-based drugs in ovarian cancer by salinomycin and its derivatives – An in vitro study
    Authors:
    M. Michalak, M.S. Lach, M. Antoszczak, A. Huczyński, W.M. Suchorska
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 537), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25030537 - link to the publication
  13. Salinomycin and its derivatives – A new class of multiple-targeted magic bullets"
    Authors:
    M. Antoszczak, A. Huczyński
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 176, strony: 208-227), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.05.031 - link to the publication
  14. Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei
    Authors:
    D. Czerwonka, Y. Barcelos, D. Steverding, A. Cioch, A. Huczyński, M. Antoszczak*
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2020, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.ejmech.2020.112900 - link to the publication
  1. Double modification of polyether ionophores: Synthesis and biological activity of novel salinomycin derivatives
    Authors:
    M. Antoszczak*, D. Czerwonka, A. Urbaniak, S. Sobczak, T.C. Chambers, A. Huczyński
    Conference:
    2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery (rok: 2019, ), Wydawca: MDPI
    Data:
    konferencja 43600
    Status:
    Published
  1. Zastosowanie antybiotyków jonoforowych oraz ich pochodnych w walce ze śpiączką afrykańską
    Authors:
    M. Sulik, M. Antoszczak*, A. Huczyński
    Book:
    Na pograniczu chemii i biologii (rok: 2019, tom: XXXIX, strony: 45557), Wydawca: Wydawnictwo Naukowe UAM
    Status:
    Published

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