Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Studies of a role of selected plant preparations in intestinal barrier protection in the human Caco-2 monolayer model related to the prevention of metabolic syndrome

2016/23/D/NZ7/00958

Keywords:

edible species low-grade inflammation Caco-2 gut barrier leakage transepithelial transport

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Monika Czerwińska 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 465 050 PLN

Project start date (Y-m-d): 2017-08-04

Project end date (Y-m-d): 2022-08-03

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Woltometr Millicell ERS-2 (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (7)
  1. In vitro α-amylase and pancreatic lipase inhibitory activity of Cornus mas L. and Cornus alba L. fruit extracts
    Authors:
    Świerczewska, A., Buchholz, T., Melzig, M.F., Czerwińska, M.E.
    Academic press:
    Journal of Food and Drug Analysis (rok: 2019, tom: 27, strony: 249-258), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.jfda.2018.06.005 - link to the publication
  2. Gut microbiota metabolism and the permeability of natural products contained in infusions from herb of European goldenrod Solidago virgaurea L
    Authors:
    Popowski, D., Czerwińska, M.E., Kruk, A., Pawłowska, K.A., Zentek, J., Melzig, M.F., Piwowarski, J.P., Granica, S.
    Academic press:
    Journal of Ethnopharmacology (rok: 2021, tom: 273, strony: 113924), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jep.2021.113924 - link to the publication
  3. Pancreatic lipase and α-amylase inhibitory activity of extracts from selected plant materials after gastrointestinal digestion in vitro
    Authors:
    Siegień, J., Buchholz, T., Popowski, D., Granica, S., Osińska, E., Melizg M.F., Czerwińska, M.E.
    Academic press:
    Food Chemistry (rok: 2021, tom: 355, strony: 129414), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.foodchem.2021.129414 - link to the publication
  4. Cornus mas and Cornus officinalis—a comparison of antioxidant and immunomodulatory activities of standardized fruit extracts in human neutrophils and Caco-2 models
    Authors:
    Czerwińska M. E., Bobińska A., Cichocka K., Buchholz T., Woliński K., Melzig M.F.
    Academic press:
    Plants (rok: 2021, tom: 10, strony: 2347), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/plants10112347 - link to the publication
  5. Potentially bio-accessible metabolites from an extract of Cornus mas fruit after gastrointestinal digestion in vitro and gut microbiota ex vivo treatment
    Authors:
    Olędzka A., Cichocka K., Woliński K., Melzig M.F., Czerwińska M.E.
    Academic press:
    Nutrients (rok: 2022, tom: 14, strony: 2287), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu14112287 - link to the publication
  6. Inhibition of digestive enzymes and antioxidant activity of extracts from fruits of Cornus alba, Cornus sanguinea subsp. hungarica and Cornus florida – a comparative study
    Authors:
    Truba J., Stanisławska I., Walasek M., Wieczorkowska W., Woliński K., Buchholz T., Melizg M.F., Czerwińska M.E.
    Academic press:
    Plants (rok: 2020, tom: 9, strony: 122), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/plants9010122 - link to the publication
  7. Fruits of Hippophaё rhamnoides in human leukocytes and Caco-2 cell monolayer models – a question about their preventive role in lipopolysaccharide leakage and cytokine secretion in endotoxemia
    Authors:
    Laskowska A.K., Wilczak A., Skowrońska W., Michel P., Melzig M.F., Czerwińska M.E.
    Academic press:
    Frontiers in Pharmacology (rok: 2022, tom: 13, strony: 9 8 1 8 7 4), Wydawca: Frontiers
    Status:
    Accepted for publication
    DOI:
    1 - link to the publication
  1. Cornus mas and Cornus officinalis – immunomodulatory activities of standardized extracts
    Authors:
    Czerwińska M.E., Bobińska A., Cichocka K., Buchholz T., Woliński K., Melzig M.F.
    Conference:
    XXIV Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego (rok: 2021, ), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Data:
    konferencja 22-24.09.2021
    Status:
    Published
  2. Anti-lipase and anti-amylase activity of extracts from selected plant materials after gastrointestinal digestion in vitro
    Authors:
    Monika E. Czerwińska, Justyna Siegień, Tina Buchholz, Dominik Popowski, Sebastian Granica, Matthias F. Melzig
    Conference:
    4th International Conference on Natural Products Utilization: from Plants to Pharmacy Shelf (ICNPU-2019) (rok: 2019, ), Wydawca: ICNPU
    Data:
    konferencja 43614
    Status:
    Published
  3. Cornus mas fruit – searching of its role in inflammation-related metabolic disorders and the fate of its metabolites after gastrointestinal transformation in vitro
    Authors:
    Agata Olędzka, Katarzyna Cichocka, Konrad Woliński, Matthias F. Melzig, Monika E. Czerwińska
    Conference:
    ACCORD 2022. Interdisciplinary Conference on Drug Sciences, Warszawa, Polska (rok: 2022, ), Wydawca: -
    Data:
    konferencja 26-28.05.2022
    Status:
    Published
  4. Sea buckthorn fruits – Potential lipid-lowering activity and preventive role in atherosclerosis-linked low-grade inflammation from epithelial cells to leukocytes response
    Authors:
    Aleksandra Wilczak, Piotr Michel, Matthias F. Melzig, Monika E. Czerwińska
    Conference:
    90th EAS Congress, Mediolan, Włochy (rok: 2022, ), Wydawca: Elsevier
    Data:
    konferencja 22-25.05.2022
    Status:
    Published
  5. The screening of anti-lipase and anti-amylase activity of selected edible plant materials
    Authors:
    Monika E. Czerwińska, Justyna Siegień, Sebastian Granica, Tina Buchholz, Matthias F. Melzig
    Conference:
    11th International Symposium on Chromatography of Natural Products (ISCNP 2018) (rok: 2018, ), Wydawca: Chair and Department of Pharmacognosy with Medicinal Plant Unit of Medical University of Lublin, Lublin
    Data:
    konferencja 4-7.06.2018
    Status:
    Published
  6. Cornus mas and Cornus alba fruits - the comparative study of α-amylase and pancreatic lipase inhibitory effects
    Authors:
    Monika E. Czerwińska , Anita Świerczewska, Tina Buchholz, Matthias F. Melzig
    Conference:
    66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) (rok: 2018, ), Wydawca: Society for Medicinal Plant and Natural Product Research (GA)
    Data:
    konferencja 26-29.08.2018
    Status:
    Published
  7. Fruits of Hippophaë rhamnoides – a question about their preventive role in gut barrier leakage, epithelial inflammation, and glucose transport.
    Authors:
    Anna Laskowska, Aleksandra Wilczak, Weronika Skowrońska, Piotr Michel, Matthias F. Melzig, Monika E. Czerwińska
    Conference:
    ACCORD 2022. Interdisciplinary Conference on Drug Sciences, Warszawa, Polska (rok: 2022, ), Wydawca: -
    Data:
    konferencja 26-28.05.2022
    Status:
    Published

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