Projects funded by the NCN

Information on the principal investigator and host institution

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The role of codependent 5-HT1a and 5-HT7 receptor signalling in the hippocampal stress response

2016/23/N/NZ4/03224

Keywords:

5-HT7 5-HT1A stress corticosterone hippocampus

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology
  • NZ3_6: Cell neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Marcin Siwiec 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 149 760 PLN

Project start date (Y-m-d): 2017-07-20

Project end date (Y-m-d): 2023-07-19

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse
    Authors:
    Marcin Siwiec, Bartosz Bobula, Michał Kiełbiński, Nikola Multan, Grzegorz Hess, Krzysztof Tokarski
    Academic press:
    Pharmacological Reports , Wydawca: Springer Nature
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. The use of serotonin type 7 receptor antagonists as a pharmacological intervention in chronic stress. Insights from animal studies
    Authors:
    Marcin Siwiec, Grzegorz Hess
    Academic press:
    The International Journal of Biochemistry & Cell Biology (rok: 2024, tom: 175, strony: 106647), Wydawca: Elsevier
    Status:
    Published
    DOI:
    0.1016/j.biocel.2024.106647 - link to the publication
  3. Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior
    Authors:
    Monika Bijata, Ewa Bączyńska, Franziska E Müller, Krystian Bijata, Julia Masternak, Adam Krzystyniak, Bernadeta Szewczyk, Marcin Siwiec, Svitlana Antoniuk, Matylda Roszkowska, Izabela Figiel, Marta Magnowska, Krzysztof H Olszyński, Agnieszka D Wardak, Adam Hogendorf, Błażej Ruszczycki, Nataliya Gorinski, Josephine Labus, Tomasz Stępień, Sylwia Tarka, Andrzej J Bojarski, Krzysztof Tokarski, Robert K Filipkowski, Evgeni Ponimaskin, Jakub Wlodarczyk
    Academic press:
    Cell Reports (rok: 2022, tom: 38, strony: 110532), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2022.110532 - link to the publication

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