Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Smart nanoparticles based on polylactides copolymers and their stereocomplexes as potential delivery systems of biological active compounds

2016/23/D/ST5/02458

Keywords:

polylactide stereocomplexes nanoparticles drug-delivery carriers

Descriptors:

  • ST5_10:
  • ST5_11:
  • ST5_22:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marek Brzeziński 

Number of co-investigators in the project: 2

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 575 500 PLN

Project start date (Y-m-d): 2017-07-19

Project end date (Y-m-d): 2021-07-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Program MestReNova (4 000 PLN)
  2. Kamera CDD (Carl Zeiss) (30 000 PLN)
  3. Krany do linii próźniowej.
  4. Laptop Lenovo.
  5. Linia próżniowa (2 szt.) (20 000 PLN)
  6. Myjka ultradźwiękowa Sonic-5.
  7. Pompy infuzyjne PHD ULTRA™ (4 szt.) (72 000 PLN)
  8. Suszarka.
  9. Program CorelDRAW X8 (2 szt.) (6 000 PLN)
  10. Wyciągarka pipet P 97 (40 000 PLN)
  11. Komputer przenośny (2 szt.) (8 000 PLN)
  12. Mikroskop optyczny z kamerą (Microscope Primovert iLED) (45 000 PLN)
  13. Program Sigma Plot (3 szt.) (9 000 PLN)
  14. Wirówka 50mL (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  1. Self-Assembly of Triblock Copolymers from Cyclic Esters as a Tool for Tuning Their Particle Morphology
    Authors:
    M. Socka, M. Brzezinski, A. Michalski, A. Kacprzak, T. Makowski, and A. Duda
    Academic press:
    Langmuir (rok: 2018, tom: 34, strony: 3701-3710), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.8b00440 - link to the publication
  2. Biocompatible polymers combined with cyclodextrins: Fascinating materials for drug delivery applications
    Authors:
    Bartłomiej Kost , Marek Brzeziński , Marta Socka, Małgorzata Baśko, Tadeusz Biela
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3404), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25153404 - link to the publication
  3. Nanobiocatalyst from lipase non-covalently immobilized on multiwalled carbon nanotubes for copolymerization of ε-caprolactone and trimethylene carbonate
    Authors:
    Marta Socka, Magdalena Sitko, Sławomir Boncel, Bartłomiej Kost, Anna Chrobok, Marek Brzezinski
    Academic press:
    Polymer Degradation and Stability (rok: 2019, tom: 170, strony: 109000), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymdegradstab.2019.109000 - link to the publication
  4. PLA/β-CD-based fibres loaded with quercetin as potential antibacterial dressing materials
    Authors:
    Bartłomiej Kost, Mariia Svyntkivska, Marek Brzezinski, Tomasz Makowski, Ewa Piorkowska, Katarzyna Rajkowska, Alina Kunicka-Styczynska, Tadeusz Biela
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2020, tom: 190, strony: 110949), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2020.110949 - link to the publication
  5. PLA Stereocomplexed Microspheres Modified with Methyl-β-Cyclodextrin as an Atropine Delivery System. Synthesis and Characterization
    Authors:
    Bartłomiej Kost, Marek Brzezinski, Magdalena Zimnicka, Marta Socka, Ewelina Wielgus, Marta Słowianek, Tadeusz Biela
    Academic press:
    Materials Today Communications (rok: 2020, tom: 25, strony: 101605), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mtcomm.2020.101605 - link to the publication
  6. Nanocarriers based on block copolymers of L-proline and lactide: The effect of core crosslinking versus its pH-sensitivity on their cellular uptake
    Authors:
    Marek Brzezinski, Bartłomiej Kost, Weronika Gonciarz, Agnieszka Krupa, Marta Socka, Maciej Rogala
    Academic press:
    European Polymer Journal (rok: 2021, tom: 156, strony: 110572), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2021.110572 - link to the publication
  7. pH-tunable nanoparticles composed of copolymers of lactide and allyl-glycidyl ether with various functionalities for the efficient delivery of anti-cancer drugs
    Authors:
    B. Kost, W. Gonciarz, A. Krupa, M. Socka, M. Rogala, T. Biela, M. Brzezinski
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2021, tom: 204, strony: 111801), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2021.111801 - link to the publication
  8. Microfluidic-assisted nanoprecipitation of biodegradable nanoparticles composed of PTMC/PCL (co)polymers, tannic acid and doxorubicin for cancer treatment
    Authors:
    Brzeziński, M., Socka, M., Makowski, T., Kost, B., Cieślak, M., Królewska-Golińska, K.
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2021, tom: 201, strony: 111598), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2021.111598 - link to the publication
  9. Simultaneous Stereocomplexation of Polylactides during Polymerization of d-LA in the Presence of a PLLA Template
    Authors:
    Marek Brzeziński, Adam Michalski, Bartłomiej Kost, Marta Socka, Marcin Florczak, Grzegorz Łapienis, Tadeusz Biela
    Academic press:
    Macromol. Chem. Phys. (rok: 2020, tom: 221, strony: 1900571), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/macp.201900571 - link to the publication
  10. Microfluidic-assisted nanoprecipitation of biodegradable nanoparticles composed of PTMC/PCL (co)polymers, tannic acid and doxorubicin for cancer treatment
    Authors:
    Brzeziński, M., Socka, M., Makowski, T., Kost, B., Cieślak, M., Królewska-Golińska, K.
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2021, tom: 201, strony: 111598), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2021.111598 - link to the publication
  11. Nanoparticles from supramolecular polylactides overcome drug resistance of cancer cells
    Authors:
    M.Brzeziński, S.Wedepohl, B.Kost, M.Calderón
    Academic press:
    European Polymer Journal (rok: 2018, tom: 109, strony: 117-123), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2018.08.060 - link to the publication
  12. Stereocomplexed micelles based on polylactides with β-cyclodextrin core as anti-cancer drug carriers
    Authors:
    B. Kost, M. Brzeziński, M. Cieślak, K. Królewska-Golińska, T. Makowski, M.Socka, T. Biela
    Academic press:
    European Polymer Journal (rok: 2019, tom: 120, strony: 109271), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2019.109271 - link to the publication
  13. Microfluidics for producing polylactide nanoparticles and microparticles and their drug delivery application
    Authors:
    Marek Brzeziński, Marta Socka, Bartłomiej Kost
    Academic press:
    Polymer International (rok: 2019, tom: 68(6), strony: 997-1014), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/pi.5753 - link to the publication
  14. Stereocomplexed PLA microspheres: Control over morphology, drug encapsulation and anticancer activity
    Authors:
    M. Brzeziński, B. Kost, S. Wedepohl, M. Socka, T. Biela, M. Calderón
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2019, tom: 184, strony: 110544), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2019.110544 - link to the publication
  15. Microfluidics for producing polylactide nanoparticles and microparticles and their drug delivery application
    Authors:
    Marek Brzeziński, Marta Socka, Bartłomiej Kost
    Academic press:
    Polymer International (rok: 2019, tom: 68(6), strony: 997-1014), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/pi.5753 - link to the publication

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