Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of E3 ligase complexes in integration of protein homeostasis and aging.

2016/23/B/NZ3/00753

Keywords:

Caenorhabditis elegans ubiquitin proteostasis aging mitochondria CHN-1 PDR-1 UFD-2

Descriptors:

  • NZ3_4: Ageing
  • NZ1_1: Molecular biology
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Wojciech Pokrzywa 

Number of co-investigators in the project: 3

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 116 875 PLN

Project start date (Y-m-d): 2017-09-28

Project end date (Y-m-d): 2021-03-27

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termocykler.
  2. Pistolet Genowy (135 000 PLN)
  3. System do szybkiego transferu białek.
  4. Mikroskop stereoskopowy (2 szt.) (64 000 PLN)
  5. Inkubator z chłodzeniem (2 szt.) (60 000 PLN)
  6. Pompa dozująca.

Information in the final report

  • Publication in academic press/journals (4)
  1. A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing
    Authors:
    Vishnu Balaji,Leonie Müller,Robin Lorenz,Éva Kevei,William H. Zhang,Ulises Santiago,Jan Gebauer,Ernesto Llamas,David Vilchez,Carlos J. Camacho,Wojciech Pokrzywa,Thorsten Hoppe
    Academic press:
    Molecular Cell (rok: 2022, tom: 82, strony: 45307), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molcel.2022.08.003 - link to the publication
  2. Ubiquitin Signaling Regulates RNA Biogenesis, Processing, and Metabolism
    Authors:
    Pankaj Thapa, Nilesh Shanmugam, Wojciech Pokrzywa
    Academic press:
    Bioessays (rok: 2019, tom: 42, strony: 45301), Wydawca: WILEY Periodicals Inc
    Status:
    Published
    DOI:
    10.1002/bies.201900171 - link to the publication
  3. Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis
    Authors:
    Vishnu Balaji, Wojciech Pokrzywa, Thorsten Hoppe
    Academic press:
    Bioessays (rok: 2018, tom: 40, strony: 45301), Wydawca: WILEY Periodicals Inc
    Status:
    Published
    DOI:
    10.1002/bies.201700223 - link to the publication
  4. A heterotypic assembly mechanism regulates CHIPE3ligase activity
    Authors:
    Aniruddha Das, Pankaj Thapa, Ulises Santiago, Nilesh Shanmugam, Katarzyna Banasiak, Katarzyna Dąbrowska, Hendrik Nolte, Natalia A Szulc, Rose M Gathungu, Dominik Cysewski, Marcus Krüger, Michał Dadlez, Marcin Nowotny, Carlos J Camacho, Thorsten Hoppe, Wojciech Pokrzywa
    Academic press:
    EMBO Journal (rok: 2022, tom: 41, strony: 45315), Wydawca: EMBO Press
    Status:
    Published
    DOI:
    10.15252/embj.2021109566 - link to the publication

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