Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Derivatives of aromatic polyene macrolides of improved selective toxicity

2016/23/B/NZ7/01223

Keywords:

polyenes antifungal agents selective toxicity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ6_7: Mycology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Sławomir Milewski 

Number of co-investigators in the project: 8

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 943 050 PLN

Project start date (Y-m-d): 2017-07-04

Project end date (Y-m-d): 2021-07-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Źródło światła monochromatycznego (45 000 PLN)
  2. Chromatograf przeciwprądowy pola odśrodkowego (445 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Light-Induced Transformation of the Aromatic Heptaene Antifungal Antibiotic Candicidin D into Its All-Trans Isomer
    Authors:
    Paweł Szczeblewski, Tomasz Laskowski, Aleksandra Bałka, Edward Borowski, Sławomir Milewski
    Academic press:
    Journal of Natural Products (rok: 2018, tom: 81, strony: 1540-1545), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jnatprod.7b00821 - link to the publication
  2. The complete stereochemistry of the antibiotic candicidin A3 (syn. ascosin A3, levorin A3)
    Authors:
    Julia Borzyszkowska-Bukowska, Paweł Szczeblewski, Agnieszka Konkol, Jakub Grynda, Katarzyna Szwarc-Karabyka, Tomasz Laskowski
    Academic press:
    Natural Products Research (rok: 2020, tom: 34, strony: 2869-2879), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14786419.2019.1596095 - link to the publication
  3. Ipertrofan revisited - the complete stereochemistry of mepartrcin A and B
    Authors:
    Paweł Szczeblewski, Witold Andrałojć, Justyna Polit, Aneta Żabka, Konrad Winnicki, Tomasz Laskowski
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 5533), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26185533 - link to the publication
  4. Isopartricin - an aromatic analogue of Amphotericin B. An old drug in a new light, which causes a structural changes
    Authors:
    Paweł Szczeblewski, Justyna Górska, Witold Andrałojć, Patryk Janke, Karolina Wąsik, Tomasz Laskowski
    Academic press:
    Antibiotics (rok: 2021, tom: 10, strony: 1102), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antibiotics10091102 - link to the publication
  5. Quest for the molecular basis of improved selective toxicity of all-trans isomers of aromatic heptaene macrolide antifungal antibiotics
    Authors:
    Julia Borzyszkowska-Bukowska, Justyna Górska, Paweł Szczeblewski, Tomasz Laskowski, Piotr Szweda, Iwona Gabriel, Jakub Jurasz, Katarzyna Kozłowska-Tylingo, Sławomir Milewski
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 10108), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221810108 - link to the publication

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