Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pharmacological suppression of ischemia/reperfusion injury to improve the function of the heart. Ex vivo and in vivo studies.

2016/23/B/NZ3/03151

Keywords:

ischemia reperfusion synergy MMP-2 posttranslational modifications

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Sawicki 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 340 150 PLN

Project start date (Y-m-d): 2017-10-02

Project end date (Y-m-d): 2022-10-01

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. 1 licencja na program do analizy żeli 2DE (15 000 PLN)
  2. System do wysokorozdzielczej ultrasonograficznej oceny parametrów pracy serca (470 000 PLN)
  3. 2 komputery (stacjonarne lub laptopy) (2 szt.) (10 000 PLN)
  4. 2 licencje na program statystyczny GraphPad Prism w najwyższej dostępnej wersji, (2 szt.) (1 100 PLN)
  5. Oprogramowanie: 2 podstawowe oprogramowania nowo zakupionych komputerów (Microsoft Office), (2 szt.) (1 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (17)
  1. Cardioprotective effect of MMP-2-inhibitor-NO-donor hybrid against ischaemia/reperfusion injury.
    Authors:
    Krzywonos-Zawadzka A1, Franczak A1, Olejnik A1, Radomski M2, Gilmer JF3, Sawicki G1,2, Woźniak M1, Bil-Lula I1.
    Academic press:
    J Cell Mol Med. (rok: 2019, tom: 23(4), strony: 2836-2848), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/jcmm.14191. - link to the publication
  2. The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases.
    Authors:
    Olejnik A, Franczak A, Krzywonos-Zawadzka A, Kałużna-Oleksy M, Bil-Lula I.
    Academic press:
    Biomed Res Int. (rok: 2018, tom: eCollection, strony: 5171945), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2018/5171945. - link to the publication
  3. Klotho protein contributes to cardioprotection during ischemia/reperfusion injury
    Authors:
    Agnieszka Olejnik, Anna Krzywonos-Zawadzka, Marta Banaszkiewicz, Iwona Bil-Lula
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2020, tom: 24, strony: 6448-6458), Wydawca: Wiley online
    Status:
    Published
    DOI:
    10.1111/jcmm.15293 - link to the publication
  4. Low frequency electromagnetic field decreases ischemia-reperfusion injury of human cardiomyocytes and supports their metabolic function.
    Authors:
    Biały D1, Wawrzyńska M2, Bil-Lula I3, Krzywonos-Zawadzka A3, Sapa-Wojciechowska A3, Arkowski J2, Woźniak M3,4, Sawicki G3,4.
    Academic press:
    Exp Biol Med (Maywood). (rok: 2018, tom: 10, strony: 809-816), Wydawca: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/1535370218779773 - link to the publication
  5. Mixture of MMP-2, MLC and NOS inhibitors affects NO metabolism and protects heart from cardiac I/R injury
    Authors:
    Anna Krzywonos-Zawadzka, Aleksandra Franczak, Grzegorz Sawicki, and Iwona Bil-Lula
    Academic press:
    Cardiology Research and Practice (rok: 2020, tom: 2020, strony: 2020:1561478), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/1561478 - link to the publication
  6. Silencing RNA for MMPs May Be Utilized for Cardioprotection
    Authors:
    Marta Banaszkiewicz ,1 Anna Krzywonos-Zawadzka , Agnieszka Olejnik , Agnieszka Noszczyk-Nowak , Iwona Bil-Lula
    Academic press:
    Cardiovascular erapeutics (rok: 2022, tom: 2022, strony: ID 9729018), Wydawca: WILEY Hindawi
    Status:
    Published
    DOI:
    10.1155/2022/9729018 - link to the publication
  7. In vivo study on doxycycline protective mechanisms during myocardial ischemia injury in rats
    Authors:
    Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Iwona Bil-Lula
    Academic press:
    Biomedicines (rok: 2024, ), Wydawca: MDPI
    Status:
    Submitted
  8. Expression of atrial‑fetal light chains in cultured human cardiomyocytes after chemical ischemia‑reperfusion injury.
    Authors:
    MARTA BANASZKIEWICZ, AGNIESZKA OLEJNIK, ANNA KRZYWONOS-ZAWADZKA, KORNELA HAŁUCHA, [AUT. KORESP.] IWONA BIL-LULA.
    Academic press:
    MOLECULAR MEDICINE REPORTS (rok: 2021, tom: 24, strony: art. 770 [10s.]), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/mmr.2021.12410 - link to the publication
  9. Tissue expression of atrial and ventricular myosin light chains in the mechanism of adaptation to oxidative stress.
    Authors:
    MARTA BANASZKIEWICZ, ANNA KRZYWONOS-ZAWADZKA, AGNIESZKA OLEJNIK, [AUT. KORESP.] IWONA BIL-LULA.
    Academic press:
    Int.J.Mol.Sci. (rok: 2020, tom: 21, strony: art.8384 [16s]), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21218384 - link to the publication

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