Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Self-association of cholesterol molecules near the mambrane oversaturated with cholesterol modelling initial stages of processes leading to atherosclerotic plaque formation: computer simulation and experiment

2016/22/M/NZ1/00187

Keywords:

atherosclerosis crystal nucleation cholesterol domains oxysterols molecular modelling

Descriptors:

  • NZ1_3: Biophysics
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marta Pasenkiewicz-Gierula 

Number of co-investigators in the project: 5

Call: HARMONIA 8 - announced on 2016-06-15

Amount awarded: 351 884 PLN

Project start date (Y-m-d): 2017-04-14

Project end date (Y-m-d): 2021-10-13

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (2)
  1. Formation of cholesterol bilayer domains precedes formation of cholesterol crystals in membranes made of the major phospholipids of human eye lens fiber cell plasma membranes.
    Authors:
    L. Mainali, M. Pasenkiewicz-Gierula, W. K. Subczynski
    Academic press:
    Current Eye Research (rok: 2020, tom: 45, strony: 162–172), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/02713683.2019.1662058 - link to the publication
  2. Data for molecular dynamic simulations in the OPLSAA force field: Partial charges of cholesterol, C7-hydroxycholesterol and C7-hydroperoxycholesterol, torsional parameters for the hydroperoxy group of C7-hydroperoxycholesterol
    Authors:
    M. Markiewicz*, R. Szczelina, M. Pasenkiewicz-Gierula
    Academic press:
    Data in Brief (rok: 2021, tom: 39, strony: 107483), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2021.07.022 - link to the publication
  3. Effect of Electrical Parameters and Cholesterol Concentration on Giant Unilamellar Vesicles Electroformation
    Authors:
    Z. Boban, A. Puljas, D. Kovač, W. K. Subczynski, M. Raguz
    Academic press:
    Cell Biochemistry and Biophysics (rok: 2020, tom: 78, strony: 157–164), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12013-020-00910-9 - link to the publication
  4. Hypothetical pathway for formation of cholesterol microcrystals initiating the atherosclerotic process
    Authors:
    W. K. Subczynski, M. Pasenkiewicz-Gierula
    Academic press:
    Cell Biochemistry and Biophysics (rok: 2020, tom: 78, strony: 241–247), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12013-020-00925-2 - link to the publication
  5. Chirality affects cholesterol-oxysterol association in water, a computational study
    Authors:
    M. Markiewicz*, R. Szczelina, B. Milanovic, W. K. Subczynski, M. Pasenkiewicz-Gierula*
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2021, tom: 19, strony: 4319-4335), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2021.07.022 - link to the publication
  1. Computer Modelling of the Lipid Matrix of Biomembranes
    Authors:
    Marta Pasenkiewicz-Gierula, Michał Markiewicz
    Book:
    Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes (rok: 2019, tom: 8, strony: 331-370), Wydawca: Springer
    Status:
    Published
  2. Role of cholesterol in maintaining the physical properties of the plasma membrane
    Authors:
    W. K. Subczynski, M. Pasenkiewicz-Gierula, J. Widomska, N. Stein
    Book:
    Cholesterol: from biophysics to the clinics (rok: 2022, tom: -, strony: 41-71), Wydawca: Academic Press is an imprint of Elsevier
    Status:
    Published

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