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Information of the project and the call

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Studies of interactions and dynamics of intrinsically disordered proteins in crucial biological processes - biophysical perspective including single molecule approach

2016/22/E/NZ1/00656

Keywords:

molecular biophysics interactions disordered proteins mRNA biomineralization single molecule spectroscopy

Descriptors:

  • NZ1_3:
  • NZ1_2:
  • NZ1_5:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Fizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Zofia Niedźwiecka 

Number of co-investigators in the project: 6

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 2 271 306 PLN

Project start date (Y-m-d): 2017-04-10

Project end date (Y-m-d): 2024-04-09

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (13)
  1. Hydrodynamic Radii of Intrinsically Disordered Proteins: Fast Prediction by Minimum Dissipation Approximation and Experimental Validation
    Authors:
    Radost Waszkiewicz, Agnieszka Michas, Michał K. Białobrzewski, Barbara P. Klepka, Maja K. Cieplak-Rotowska, Zuzanna Staszałek, Bogdan Cichocki, Maciej Lisicki, Piotr Szymczak, and Anna Niedzwiecka
    Academic press:
    The Journal of Physical Chemistry Letters (rok: 2024, tom: 15, strony: 5024-5033), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.4c00312 - link to the publication
  2. Exploring the CNOT1(800–999) HEAT Domain and Its Interactions with Tristetraprolin (TTP) as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
    Authors:
    Maja K. Cieplak-Rotowska, Michał Dadlez, Anna Niedźwiecka
    Academic press:
    Biomolecules (rok: 2025, tom: 15(3), 403, strony: 46047), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom15030403 - link to the publication
  3. Diffusion coefficients of elastic macromolecules
    Authors:
    Bogdan Cichocki, Marcin Rubin, Anna Niedźwiecka, Piotr Szymczak
    Academic press:
    Journal of Fluid Mechanics (rok: 2019, tom: 878, strony: R3), Wydawca: CAMBRIDGE UNIV PRESS
    Status:
    Published
    DOI:
    10.1017/jfm.2019.652 - link to the publication
  4. Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry
    Authors:
    Cieplak-Rotowska Maja K., Tarnowski Krzysztof, Rubin Marcin, Fabian Marc R., Sonenberg Nahum, Dadlez Michał, Niedźwiecka Anna
    Academic press:
    Journal of The American Society for Mass Spectrometry (rok: 2018, tom: 29, strony: 158-173), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13361-017-1830-9 - link to the publication
  5. The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor
    Authors:
    Nikola Sozańska, Barbara P. Klepka, Anna Niedzwiecka, Lilia Zhukova, Michał Dadlez, Beata Greb-Markiewicz, Andrzej Ożyhar, Aneta Tarczewska
    Academic press:
    Cell Communication and Signaling (rok: 2025, tom: 1,06527777777778, strony: 46042), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-025-02154-7 - link to the publication
  6. Diversity of hydrodynamic radii of intrinsically disordered proteins
    Authors:
    Michał K. Białobrzewski, Barbara P. Klepka, Agnieszka Michaś, Maja K. Cieplak-Rotowska, Zuzanna Staszałek, Anna Niedźwiecka
    Academic press:
    European Biophysics Journal (rok: 2023, tom: 52, strony: 607-618), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00249-023-01683-8 - link to the publication
  1. Interplay of protein interactions involved in miRNA-mediated gene silencing, as revealed by HDX MS
    Authors:
    M. K. Cieplak-Rotowska, K. Tarnowski, M. Dadlez, M. R. Fabian, N. Sonenberg, A. Niedźwiecka
    Conference:
    19th IUPAB and 11th EBSA Congress (rok: 2017, ), Wydawca: European Biophysics Journal with Biophysics Letters; Springer w imieniu European Biophysics Societes' Association
    Data:
    konferencja 16-20 lipca 2017
    Status:
    Published
    DOI:
    link to the publication
  2. Calcium-mediated aggregation of intrinsically disordered polyanionic proteins involved in early stages of coral biomineralization
    Authors:
    Barbara Klepka, Anna Niedźwiecka
    Conference:
    18th Congress of the Polish Biophysical Society (PTBF) (rok: 2022, ), Wydawca: Polskie Towarzystwo Biofizyczne
    Data:
    konferencja 6 – 9 września 2022
    Status:
    Published
  3. Fluorescence Correlation Spectroscopy Studies of Properties and Interactions of Intrinsically Disordered Proteins Involved in Regulation of Gene Expression
    Authors:
    K. Białobrzewski, A. M. Michaś, M. K. Cieplak-Rotowska, M. Duszka, A. Niedźwiecka
    Conference:
    18th Congress of the Polish Biophysical Society (rok: 2022, ), Wydawca: Polskie Towarzystwo Biofizyczne
    Data:
    konferencja 06-09.09.2022
    Status:
    Published
  4. Studies of interactions and conformational dynamics of intrinsically disordered proteins involved in miRNA-mediated gene silencing
    Authors:
    M. K. Białobrzewski, A. M. Michaś, M. K. Cieplak-Rotowska, A. Niedźwiecka
    Conference:
    Zakopane School of Physics, Breaking Frontiers: Submicron Structures in Physics and Biology (rok: 2023, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 23-27.05.2023
    Status:
    Published
  5. Formation of coral acid-rich protein aggregates with calcium cations - is there a liquid-liquid phase separation out there?
    Authors:
    Barbara Klepka, Agnieszka Michaś, Anna Niedźwiecka
    Conference:
    Cellular mechanisms driven by phase separation (rok: 2022, ), Wydawca: EMBL/EMBO
    Data:
    konferencja 9 – 12 maja 2022
    Status:
    Published
  6. Intrinsically disordered proteins that regulate fundamental biological processes – challenging targets for biophysical studies
    Authors:
    A. Niedźwiecka, M. K. Cieplak-Rotowska, M. K. Białobrzewski, B. Klepka
    Conference:
    Zakopane School of Physics -Breaking Frontiers: Submicron Structures in Physics and Biology (rok: 2023, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 23-27.05.2023
    Status:
    Published
  7. FCS and confocal studies of early stages of biomineralization steered by intrinsically disordered coral acid-rich proteins
    Authors:
    Barbara Klepka, Anna Niedźwiecka
    Conference:
    7th European Workshop on Advanced Fluorescence Methods 2022 (rok: 2022, ), Wydawca: LMU Munich
    Data:
    konferencja 5 - 9 grudnia 2022
    Status:
    Published
  8. Coral acid-rich protein-mediated emergence of calcium carbonate spherulitic structures,
    Authors:
    B. Klepka, T. Wojciechowski, A. Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 8 (rok: 2023, ), Wydawca: European Physical Society
    Data:
    konferencja 14-18 maja 2023
    Status:
    Published
  9. Formation of calcium carbonate spherulites driven by coral polyanionic protein
    Authors:
    B. Klepka, T. Wojciechowski, A. Niedźwiecka
    Conference:
    Zakopane School of Physics -Breaking Frontiers: Submicron Structures in Physics and Biology (rok: 2023, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 23-27 maja 2023
    Status:
    Published
  10. Influence of aromatic substituents at mRNA 5' cap analogues on their interactions with human eIF4E protein
    Authors:
    Michał Białobrzewski, Karolina Piecyk, Marzena Jankowska-Anyszka, Janusz Stępiński, Edward Darżynkiewicz, Anna Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 7 (rok: 2019, ), Wydawca: European Physical Society
    Data:
    konferencja 15-19 maja 2019
    Status:
    Published
  11. Identification of the GW182 silencing domain-binding site on CNOT1
    Authors:
    Agnieszka Stelmachowska, Maja Cieplak-Rotowska, Anna Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 7 (rok: 2019, ), Wydawca: European Physical Society
    Data:
    konferencja 15-19 maja 2019
    Status:
    Published
  12. Liquid-liquid phase separation of GW182 Silencing Domain
    Authors:
    M. K. Białobrzewski, Z. Staszałek, A. Michaś, A. Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 8 (rok: 2023, ), Wydawca: European Physical Society
    Data:
    konferencja 14-18 June 2023
    Status:
    Published
  13. Expression and purification of intrinsically disordered C-terminal fragments of PARN in fusion with mCherry for FCS and SEC studies
    Authors:
    Z. Staszałek, M. K. Białobrzewski, A. Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 8 (rok: 2023, ), Wydawca: European Physical Society
    Data:
    konferencja 14-18 czerwca 2023
    Status:
    Published

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