Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The reins of NETs - identification of mechanisms controlling the inflammatory potential of NETs

2016/22/E/NZ6/00336

Keywords:

granulocytes neutrophil traps NETs inflammatory state

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Kozieł 

Number of co-investigators in the project: 5

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 989 000 PLN

Project start date (Y-m-d): 2017-04-12

Project end date (Y-m-d): 2024-04-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (1)
  1. Citrullination-resistant LL-37 is a potent antimicrobial agent in the inflammatory environment high in arginine deiminase activity
    Authors:
    Bryzek D, Golda A, Budziaszek J, Kowalczyk D, Wong A, Bielecka E, Shakamuri P, Svoboda P, Pohl J, Potempa J, Koziel J.
    Academic press:
    International Journal of Molecular Sciences, special issue Peptides for Health Benefits 2020 (rok: 2020, tom: 21, strony: 9126), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239126 - link to the publication
  2. Conjugate of Enkephalin and Temporin Peptides as a Novel Therapeutic Agent for Sepsis
    Authors:
    Golda A, Kosikowska-Adamus P, Babyak O, Lech M, Wysocka M, Lesner A, Potempa J, Koziel J.
    Academic press:
    Bioconjugate Chemistry (rok: 2018, tom: 29, strony: 4127-4139), Wydawca: ACSPublications
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.8b00763 - link to the publication
  3. Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor.
    Authors:
    Aliko A, Kamińska M, Falkowski K, Bielecka E, Benedyk-Machaczka M, Malicki S, Kozieł J, Wong A, Bryzek D, Kantyka T, Mydel P.
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: 20(9), strony: pii: E2174), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20092174. - link to the publication
  4. A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.
    Authors:
    Wong A, Bryzek D, Dobosz E, Scavenius C, Svoboda P, Rapala-Kozik M, Lesner A, Frydrych I, Enghild J, Mydel P, Pohl J, Thompson PR, Potempa J, Koziel J.
    Academic press:
    J of Immunology (rok: 2018, tom: Apr 1;200(7), strony: 2327-2340), Wydawca: The American Association of Immunologists, Inc.
    Status:
    Published
    DOI:
    10.4049/jimmunol.1701391 - link to the publication
  5. The case for periodontitis in the pathogenesis of rheumatoid arthritis
    Authors:
    Potempa J., Mydel P., Koziel J.
    Academic press:
    Nature Reviews Rheumatology (rok: 2017, tom: 13(10), strony: 606-620), Wydawca: Macmillan Publishers Limited, part of Springer Nature
    Status:
    Published
    DOI:
    10.1038/nrrheum.2017.132 - link to the publication
  6. Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits.
    Authors:
    Bryzek D, Ciaston I, Dobosz E, Gasiorek A, Makarska A, Sarna M, Eick S, Puklo M, Lech M, Potempa B, Potempa J, Koziel J.
    Academic press:
    PLoS Pathogens (rok: 2019, tom: 15(5), strony: e1007773), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1007773 - link to the publication
  7. Pros and cons of causative association between periodontitis and rheumatoid arthritis.
    Authors:
    Koziel J, Potempa J.
    Academic press:
    Periodontol 2000 (rok: 2022, tom: 89(1), strony: 83-98), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/prd.12432 - link to the publication
  8. The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus.
    Authors:
    Golda A, Kosikowska-Adamus P, Kret A, Babyak O, Wójcik K, Dobosz E, Potempa J, Lesner A, Koziel J.
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: 20(19), strony: E4761), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20194761 - link to the publication
  1. Characterization of neutrophil extracellular traps (NETs) induced by host and pathogens proteases
    Authors:
    Danuta Bryzek1, Anna Gąsiorek1, Maciej Lech1,2, Jan Potempa1,3, Joanna Kozieł1
    Conference:
    8th International Weigl Conference (rok: 2019, ), Wydawca: Grupa Medica s.c.
    Data:
    konferencja 2019-06-26 - 2019-06-28
    Status:
    Published

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