Projects funded by the NCN

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Studying the molecular dynamics, phase transitions, isomerizations, at different temperature and pressure conditions in binary mixtures composed of active pharmaceutical ingredient (API) and modified saccharide.

2016/22/E/NZ7/00266

Keywords:

modified saccharide active pharmaceutical ingredient high pressures molecular dynamics phase transitions isomerization

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Śląski Uniwersytet Medyczny w Katowicach, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej w Sosnowcu

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewa Ozimina-Kamińska 

Number of co-investigators in the project: 7

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 632 900 PLN

Project start date (Y-m-d): 2017-04-06

Project end date (Y-m-d): 2023-04-05

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Szerokozakresowy analizator impedancji (250 000 PLN)
  2. Zestaw do badań wysokociśnieniowych (300 000 PLN)

Information in the final report

  • Publication in academic press/journals (34)
  1. Anomalous narrowing of the shape of the structural process in derivatives of trehalose at high pressure. The role of the internal structure.
    Authors:
    Dawid Heczko, Joanna Grelska, Karolina Jurkiewicz, Patrycja Spychalska, Anna Kasprzycka, Kamil Kamiński, Marian Paluch, Ewa Kamińska
    Academic press:
    Journal of Molecular Liquids (rok: 2021, tom: 336, strony: 116321), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2021.116321 - link to the publication
  2. Conformational changes underlying variation in the structural dynamics of the materials confined at the nanometric scale.
    Authors:
    Aldona Minecka, Ewa Kaminska, Magdalena Tarnacka, Agnieszka Talik, Iwona Grudzka-Flak, Kamila Wolnica, Mateusz Dulski, Kamil Kaminski, Marian Paluch
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2018, tom: 20, strony: 30200-30208), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8CP06086J - link to the publication
  3. High pressure aging studies on the low-molecular weight glass-forming pharmaceutical – probucol.
    Authors:
    Aldona Minecka, Barbara Hachuła, Karolina Jurkiewicz, Kamil Kamiński, Marian Paluch, Ewa Kamińska
    Academic press:
    Journal of Molecular Liquids (rok: 2021, tom: 321, strony: 114626), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.114626 - link to the publication
  4. Impact of Intermolecular Interactions, Dimeric Structures on the Glass Forming Ability of Naproxen, and a Series of Its Derivatives
    Authors:
    Aldona Minecka, Ewa Kaminska, Magdalena Tarnacka, Iwona Grudzka-Flak, Mariola Bartoszek, Kamila Wolnica, Mateusz Dulski, Kamil Kaminski, and Marian Paluch
    Academic press:
    Molecular Pharmaceutics (rok: 2018, tom: 15, strony: 4764-4776), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.8b00725 - link to the publication
  5. Influence of annealing in the close vicinity of Tg on the reorganization within dimers and its impact on the crystallization kinetics of Gemfibrozil.
    Authors:
    Ewa Kamińska, Aldona Minecka, Magdalena Tarnacka, Barbara Hachuła, Kamil Kamiński, Marian Paluch
    Academic press:
    Molecular Pharmaceutics (rok: 2020, tom: 17, strony: 990-1000), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.9b01244 - link to the publication
  6. Melts of Octaacetyl Sucrose as Oral-Modified Release Dosage Forms for Delivery of Poorly Soluble Compound in Stable Amorphous Form.
    Authors:
    D. Haznar-Garbacz, E. Kaminska, D. Zakowiecki, M. Lachmann, K. Kaminski, G. Garbacz, P. Dorożyński, P. Kulinowski
    Academic press:
    AAPS PharmSciTech (rok: 2018, tom: 19, strony: 951-960), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1208/s12249-017-0912-0 - link to the publication
  7. Relationship between Nanoscale Supramolecular Structure, Effectiveness of Hydrogen Bonds, and Appearance of Debye Process.
    Authors:
    Karolina Jurkiewicz, Barbara Hachuła, Ewa Kaminska, Katarzyna Grzybowska, Sebastian Pawlus, Roman Wrzalik, Kamil Kamiński, Marian Paluch
    Academic press:
    Journal of Physical Chemistry C (rok: 2020, tom: 124, strony: 2672-2679), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.9b09803 - link to the publication
  8. Studies on dynamics and isomerism in supercooled photochromic compound Aberchrome 670 with the use of different experimental techniques.
    Authors:
    Wioleta Edyta Śmiszek-Lindert, Ewa Kamińska, Aldona Minecka, Dawid Heczko, Olga Madejczyk, Magdalena Tarnacka, Karolina Jurkiewicz, Andrzej Dzienia, Kamil Kamiński and Marian Paluch
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2018, tom: 20, strony: 18009-18019), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8CP02993H - link to the publication
  9. Studies on the molecular dynamics of acetylated oligosaccharides of different topologies (linear versus cyclic).
    Authors:
    Dawid Heczko, Ewa Kamińska, Aldona Minecka, Magdalena Tarnacka, Patrycja Waliłko, Anna Kasprzycka, Kamil Kaminski, Marian Paluch
    Academic press:
    Carbohydrate Polymers (rok: 2019, tom: 206, strony: 273-280), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.118 - link to the publication
  10. Anormal Thermal History Effect on the Structural Dynamics of Probucol Infiltrated into Porous Alumina.
    Authors:
    Agnieszka Talik, Magdalena Tarnacka, Aldona Minecka, Barbara Hachuła, Joanna Grelska, Karolina Jurkiewicz, Kamil Kaminski, Marian Paluch, Ewa Kaminska,
    Academic press:
    J. Phys. Chem. C (rok: 2021, tom: 125, strony: 3901-3912), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.0c10560 - link to the publication
  11. Does the molecular mobility and flexibility of the saccharide ring affect the glass-forming ability of naproxen in binary mixtures?
    Authors:
    A. Minecka, E. Kamińska, M. Tarnacka, K. Jurkiewicz, A. Talik, K. Wolnica, M. Dulski, A. Kasprzycka, P. Spychalska, G. Garbacz, K. Kamiński, M. Paluch
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2020, tom: 141, strony: 105091), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2019.105091 - link to the publication
  12. Studying structural and local dynamics in model H-bonded active ingredient – Curcumin in the supercooled and glassy states at various thermodynamic conditions.
    Authors:
    Aldona Minecka, Ewa Kamińska, Dawid Heczko, Karolina Jurkiewicz, Kamila Wolnica, Mateusz Dulski, Barbara Hachuła, Wojciech Pisarski, Magdalena Tarnacka, Agnieszka Talik, Kamil Kamiński, Marian Paluch
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2019, tom: 135, strony: 38-50), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2019.05.005 - link to the publication
  13. The Impact of Liquid Crystalline Phase Ordering on the Thermodynamic Scaling of Itraconazole.
    Authors:
    Dawid Heczko, Ewa Kaminska, Magdalena Tarnacka, Kajetan Koperwas, Andrzej Dzienia, Miroslaw Adam Chorazewski, Kamil Kaminski, Marian Paluch
    Academic press:
    Journal of Physical Chemistry C (rok: 2019, tom: 123, strony: 4558-4566), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.8b12074 - link to the publication
  14. The impact of various azole antifungals on the liquid crystalline ordering in itraconazole.
    Authors:
    Dawid Heczko, Ewa Kamińska, Karolina Jurkiewicz, Magdalena Tarnacka, Katarzyna Merkel, Kamil Kamiński, Marian Paluch
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 307, strony: 112959), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.112959 - link to the publication
  15. Influence of the Internal Structure and Intermolecular Interactions on the Correlation Between Structural () and Secondary (β-JG)-relaxation Below the Glass Transition Temperature in Neat Probucol and its Binary Mixtures with Modified Saccharides.
    Authors:
    A. Minecka, M. Tarnacka, K. Jurkiewicz, B. Hachuła, K. Kamiński, M. Paluch, E. Kamińska
    Academic press:
    Journal of Physical Chemistry B (rok: 2020, tom: 124, strony: 4821-4834), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.0c02384 - link to the publication
  16. Studies on the Vitrified and Cryomilled Bosentan.
    Authors:
    Aldona Minecka, Krzysztof Chmiel, Karolina Jurkiewicz, Barbara Hachuła, Rafał Łunio, Daniel Żakowiecki, Kinga Hyla, Bartłomiej Milanowski, Kajetan Koperwas, Kamil Kamiński, Marian Paluch, Ewa Kamińska
    Academic press:
    Molecular Pharmaceutics (rok: 2022, tom: 19, strony: 80-90), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.1c00613 - link to the publication
  17. Studying the crystal growth of selected APIs from single and two-component systems above and below the glass transition temperature.
    Authors:
    Olga Madejczyk, Aldona Minecka, Ewa Kaminska, Dawid Heczko, Magdalena Tarnacka, Kamila Wolnica, Kamil Kaminski,Marian Paluch
    Academic press:
    Crystal Growth&Design (rok: 2019, tom: 19, strony: 1031−1040), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.cgd.8b01562 - link to the publication
  18. The impact of chemical structure on the formation of the medium-range order and dynamical properties of selected antifungal APIs.
    Authors:
    Dawid Heczko, Karolina Jurkiewicz, Magdalena Tarnacka, Joanna Grelska, Roman Wrzalik, Kamil Kamiński, Marian Paluch, Ewa Kamińska
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2020, tom: 22, strony: 28202-28212), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D0CP02332A - link to the publication
  19. Breakdown of the isochronal structural (α) and secondary (JG β) exact superpositioning in probucol - A low molecular weight pharmaceutical
    Authors:
    E. Kamińska, A. Minecka, M. Tarnacka, K. Kamiński, M. Paluch
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 299, strony: 112169), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2019.112169 - link to the publication
  20. Dramatic slowing down of the conformational equilibrium in the silyl derivative of glucose in the vicinity of the glass transition temperature
    Authors:
    K. Wolnica, M. Dulski, E. Kamińska, M. Tarnacka, R. Wrzalik, A. Zięba, A. Kasprzycka, M. Nowak, K. Jurkiewicz, W. Szeja, K. Kaminski, M. Paluch
    Academic press:
    Soft Matter (rok: 2019, tom: 15, strony: 7429-7437), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C9SM01259A - link to the publication
  21. High-pressure dielectric studies on 1,6-anhydro-β-D-mannopyranose (plastic crystal) and 2,3,4-tri-O-acetyl-1,6-anhydro-β-D-glucopyranose (canonical glass).
    Authors:
    Dawid Heczko, Ewa Kamińska, Aldona Minecka, Andrzej Dzienia, Karolina Jurkiewicz, Magdalena Tarnacka, Agnieszka Talik, Kamil Kamiński, Marian Paluch
    Academic press:
    The Journal of Chemical Physics (rok: 2018, tom: 148, strony: 204510), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.5032209 - link to the publication
  22. Studies on the internal medium-range ordering and high pressure dynamics in modified ibuprofens.
    Authors:
    Aldona Minecka, Ewa Kamińska, Karolina Jurkiewicz, Dawid Heczko, Barbara Hachuła, Wojciech Pisarski, Kamil Kamiński, Marian Paluch
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2020, tom: 22, strony: 295-305), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C9CP04886C - link to the publication
  23. Studying molecular dynamics of the slow, structural and secondary relaxation processes in series of substituted ibuprofens.
    Authors:
    A. Minecka, E. Kamińska, D. Heczko, M. Tarnacka, I. Grudzka-Flak, M. Bartoszek, A. Zięba, R. Wrzalik, W. E. Śmiszek-Lindert, M. Dulski, K. Kaminski, and M. Paluch
    Academic press:
    The Journal of Chemical Physics (rok: 2018, tom: 148, strony: 224505), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.5026818 - link to the publication
  24. Variation in the local ordering, H-bonding pattern and molecular dynamics in the pressure densified ritonavir.
    Authors:
    Dawid Heczko, Paulina Jesionek, Barbara Hachuła, Karolina Jurkiewicz, Joanna Grelska, Magdalena Tarnacka, Kamil Kamiński, Marian Paluch, Ewa Kamińska
    Academic press:
    Journal of Molecular Liquids (rok: 2022, tom: 351, strony: 118666), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2022.118666 - link to the publication
  25. Varying thermodynamic conditions as a new way to tune the molecular order in glassy itraconazole.
    Authors:
    Dawid Heczko, Ewa Kamińska, Magdalena Tarnacka, Karolina Jurkiewicz, Mateusz Dulski, Anna Bębenek, Grzegorz Garbacz, Kamil Kamiński, Marian Paluch
    Academic press:
    Journal of Molecular Liquids (rok: 2019, tom: 286, strony: 110920), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2019.110920 - link to the publication
  26. A study on the progress of mutarotation above and below the Tg and the relationship between constant rates and structural relaxation times
    Authors:
    K. Wolnica, M. Dulski, E. Kaminska, A. Cecotka, M. Tarnacka, R. Wrzalik, K. Kaminski, M. Paluch
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2017, tom: 19, strony: 20949-20958), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C7CP02046E - link to the publication
  27. Anhydrosaccharides- a new class of the fragile plastic crystals.
    Authors:
    Ewa Kaminska, Olga Madejczyk, Magdalena Tarnacka, Karolina Jurkiewicz, Kamila Wolnica, Wioleta Edyta Śmiszek-Lindert, Kamil Kaminski, Marian Paluch
    Academic press:
    The Journal of Chemical Physics (rok: 2018, tom: 148, strony: 74501), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.5011672 - link to the publication
  28. High pressure as a novel tool for the cationic ROP of g-butyrolactone.
    Authors:
    Roksana Bernat, Paulina Maksym, Magdalena Tarnacka, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz, Tadeusz Biela, Sylwia Golba, Ewa Kamińska, Marian Paluch, Kamil Kamiński
    Academic press:
    RSC Advances (rok: 2021, tom: 11, strony: 34806), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1RA06081C - link to the publication
  29. High pressure studies on structural and secondary relaxation dynamics in silyl derivative of glucose.
    Authors:
    Aldona Minecka, Ewa Kamińska, Magdalena Tarnacka, Andrzej Dzienia, Olga Madejczyk, Patrycja Waliłko, Anna Kasprzycka, Kamil Kamiński, Marian Paluch
    Academic press:
    The Journal of Chemical Physics (rok: 2017, tom: 147, strony: 64502), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4989679 - link to the publication
  30. How does pressure affect the molecular dynamics, intramolecular interactions, and the relationship between structural (α) and secondary (JG-β) relaxation above and below the glass transition temperature in binary mixtures of H-bonded API – probucol and acetylated saccharides?
    Authors:
    Aldona Minecka, Barbara Hachuła, Kamil Kamiński, Marian Paluch, Ewa Kamińska
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2021, tom: 164, strony: 105894), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2021.105894 - link to the publication
  31. Impact of the Chain Length and Topology of the Acetylated Oligosaccharide on the Crystallization Tendency of Naproxen from Amorphous Binary Mixtures
    Authors:
    Aldona Minecka, Magdalena Tarnacka, Karolina Jurkiewicz, Barbara Hachuła, Roman Wrzalik, Kamil Kaminski, Marian Paluch, Ewa Kaminska
    Academic press:
    Molecular Pharmaceutics (rok: 2021, tom: 18, strony: 347-358), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.0c00982 - link to the publication
  32. Influence of High Pressure on the Local Order and Dynamical Properties of the Selected Azole Antifungals.
    Authors:
    Dawid Heczko, Karolina Jurkiewicz, Joanna Grelska, Kamil Kamiński, Marian Paluch, Ewa Kamińska
    Academic press:
    Journal of Physical Chemistry B (rok: 2020, tom: 124, strony: 11949-11961), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.0c08083 - link to the publication
  33. Studying the crystallization of various polymorphic forms of nifedipine from binary mixtures with the use of different experimental techniques
    Authors:
    O. Madejczyk, E. Kaminska, M. Tarnacka, M. Dulski, K. Jurkiewicz, K. Kaminski, M. Paluch
    Academic press:
    Molecular Pharmaceutics (rok: 2017, tom: 14, strony: 2116-2125), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.7b00228 - link to the publication
  34. Unexpected Crossover in the kinetics of mutarotation in the supercooled region: the role of H-bonds.
    Authors:
    K. Wolnica, M. Dulski, E. Kaminska, M. Tarnacka,R. Wrzalik,W. E. Śmiszek- Lindert, K. Kaminski and M. Paluch
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 5312), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-23117-8 - link to the publication

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