Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Modulation of amygdala neural network activity by the 5-HT7 receptor

2016/21/B/NZ4/03618

Keywords:

amygdala 5-HT7 electrophysiology plasticity depression

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Tokarski 

Number of co-investigators in the project: 4

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 047 510 PLN

Project start date (Y-m-d): 2017-02-17

Project end date (Y-m-d): 2023-02-16

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dwukanałowy wzmacniacz do eksperymentów patch clamp (89 000 PLN)
  2. Mikromanipulator (104 000 PLN)
  3. Mikroskop Axio Examiner z wyposażeniem dodatkowym.
  4. Osmometr (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. 5-HT7 receptors enhance inhibitory synaptic input to principal neurons in the mouse basal amygdala.
    Authors:
    Kusek M, Siwiec M, Sowa JE, Bobula B, Bilecki W, Ciurej I, Kaczmarczyk M, Kowalczyk T, Maćkowiak M, Hess G, Tokarski K
    Academic press:
    Neuropharmacology (rok: 2021, tom: 198, strony: 45301), Wydawca: https://www.elsevier.com/locate/neuropharm
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2021.108779 - link to the publication
  2. Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior.
    Authors:
    Bijata M, Bączyńska E, Müller FE, Bijata K, Masternak J, Krzystyniak A, Szewczyk B, Siwiec M, Antoniuk S, Roszkowska M, Figiel I, Magnowska M, Olszyński KH, Wardak AD, Hogendorf A, Ruszczycki B, Gorinski N, Labus J, Stępień T, Tarka S, Bojarski AJ, Tokarski K, Filipkowski RK, Ponimaskin E, Wlodarczyk J.
    Academic press:
    Cell Reports (rok: 2022, tom: 38, strony: 45314), Wydawca: CELPRESs
    Status:
    Published
    DOI:
    10.1016/j.celrep.2022.110532 - link to the publication
  1. 5-HT7 receptor-mediated modulation of synaptic transmission in the mice basolateral amygdala
    Authors:
    Sowa, J. E., Kusek, M., Siwiec, M., Hess, G., Tokarski, K
    Conference:
    31st Congress of the European-College-of-Neuropsychopharmacology (ECNP)"The future of CNS treatments" (rok: 2018, ), Wydawca: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    Data:
    konferencja 06-09.10.2018
    Status:
    Published
  2. Effects of 5-HT7 receptor activation on basolateral amygdala neuron excitability and synaptic transmission
    Authors:
    Sowa, J. E., Kusek, M., Siwiec, M., Hess, G., Tokarski, K
    Conference:
    11th FENS Forum of Neuroscience (rok: 2018, ), Wydawca: FENS
    Data:
    konferencja 07-11.07.2018
    Status:
    Published
  3. 5-HT7 receptor increases GABAergic transmission in mouse basolateral amygdala.
    Authors:
    Sowa JE, Kusek M., Siwiec M., Hess G., Tokarski K
    Conference:
    11th Conference on Electrophysiological Techniques in Bioelectricity Research (rok: 2018, ), Wydawca: Nencki Institute of Experimental Biology, Polish Neuroscience Society
    Data:
    konferencja 25-26.05.2018
    Status:
    Published

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