Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Modulation of the expression and activation of transcription factors Nrf2 and NF-kappaB by new synthetic triterpenoids and their conjugates potential chempreventive and therapeutic agents

2016/21/B/NZ7/01758

Keywords:

Nrf2 NF-kappaB triterpenoids chemoprevention liver and pancreas cancers

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wanda Baer-Dubowska 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 941 800 PLN

Project start date (Y-m-d): 2017-02-14

Project end date (Y-m-d): 2021-11-13

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Analizator systemowy Chemi DocTM (140 000 PLN)
  2. Komputer z oprogramowaniem do analizy statystycznej (4 500 PLN)
  3. Analizator komórek Muse (TM) (55 000 PLN)
  4. Stacja robocza do analizy stężenia białka z wykorzystaniem spektroskopii IR oraz opartej na wzbudzeniu fluorescencyjnym analizy mutipleksowej.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (12)
  1. Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Małgorzata Kucińska, Robert Kleszcz, Jacek Kujawski, Hanna Piotrowska-Kempisty, Adam Plewiński, Marek Murias, Wanda Baer-Dubowska
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 688), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14070688 - link to the publication
  2. Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Wanda Baer-Dubowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1230), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031230 - link to the publication
  3. Morpholide derivative of the novel oleanolic oxime and succinic acid conjugate diminish the expression and activity of NF-κB and STATs in human hepatocellular carcinoma cells
    Authors:
    Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Maria Narożna, Hanna Szaefer, Wanda Baer-Dubowska
    Academic press:
    Chemico-Biological Interactions (rok: 2019, tom: 311, strony: 108786), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.cbi.2019.108786 - link to the publication
  4. Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-κBmediated transcription in HepG2 hepatoma cells
    Authors:
    Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Jarosław Paluszczak, Hanna Szaefer, Maria Narożna, Lucjusz Zaprutko, Wanda Baer-Dubowska
    Academic press:
    BIOORGANIC CHEMISTRY (rok: 2019, tom: 93, strony: 103326), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bioo - link to the publication
  5. Activation of the Nrf2 response by oleanolic acid oxime morpholide (3-hydroxyiminoolean-12-en-28-oic acid morpholide) is associated with its ability to induce apoptosis and inhibit proliferation in HepG2 hepatoma cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Barbara Bednarczyk-Cwynar, Hanna Szaefer, Wanda Baer-Dubowska
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 883, strony: art.173307 str 1-11), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173307 - link to the publication
  6. Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs
    Authors:
    Wanda Baer-Dubowska, Maria Narożna, Violetta Krajka-Kuźniak
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 4957), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26164957 - link to the publication
  7. The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Robert Kleszcz, Wanda Baer-Dubowska
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 32), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14010032 - link to the publication
  1. Modulation of NF-kappaB signaling pathway by oleanolic acid derivatives and its conjugates with non-steroidal ant-inflammatory drugs in HepG2 hepatocellular cells line
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Robert Kleszcz, Wanda Baer-Dubowska
    Conference:
    BIO2018 Congress and 51st Meeting of the Polish Biochemical Society (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21 września
    Status:
    Published
  2. Modulation of the Nrf2 signaling pathwya by the new oleanolic acid derivatives in human hepatocellular carcinoma cells
    Authors:
    Krajka-Kuźniak V., Paluszczak J., Szaefer H., Dednarczyk-Cwynar B., Baer-Dubowska W.
    Conference:
    42nd FEBS Congress Jerusalem, Israel (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja 40100
    Status:
    Published
  3. Oleanolic acid oxime derivatives modulate NF-κB signaling pathway leading to cell cycle arrest in pancreatic cancer cells
    Authors:
    Maria Narożna, Violetta Krajak-Kuźniak, Robert Kleszcz, Wanda Baer-Dubowska
    Conference:
    AACR Annual Meeting 2020, Philadelphia, PA, USA (rok: 2020, ), Wydawca: AACR
    Data:
    konferencja June 22-24, 2020
    Status:
    Published
  4. Synthesis and modulation of NF-kappaB pathway by new conjugates of oleanolic acid oximes and aspirin
    Authors:
    Bednarczyk-Cwynar B, Krajka-Kuźniak V., Paluszczak J., Szaefer H., Baer-Dubowska W.
    Conference:
    42nd FEBS Congress Jesrusalem, Israel (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja 40100
    Status:
    Published
  5. The effect of novel oleanolic acid derivatives on the expression and activity of transcription factors Nrf2 and Stat3 in HepG2 cells
    Authors:
    Narożna M, Krajka-Kuźniak V., Szaefer H., Baer-Dubowska W
    Conference:
    XXI Gliwice Scientific Meetings 2017 (rok: 2017, ), Wydawca: Instytut Onkologii im Marii Skłodowskiej-Curie i Gliwice, Śląski Uniwersytet Techniczny
    Data:
    konferencja 17-18 /11
    Status:
    Published
  6. Benzyl and morpholide derivatives of the novel oleanolic acid oximes conjugated with diclofenac downregulate the Nrf2-ARE signaling pathway in human hepatocellular cancer cells in comparison with normal hepatocytes
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
    Conference:
    20th International Congress of Young Medical Scientists (rok: 2020, ), Wydawca: Uniwersytet Medyczny w Poznaniu
    Data:
    konferencja 28-30th May, 2020
    Status:
    Published
  7. Morpholide derivatives of the novel oleanolic oxime conjugated with diclofenac and indomethacin modulate the cell cycle, proliferation, apoptosis and inflammation markers in human hepatocellular cancer cells.
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Szaefer Hanna, Paluszczak Jarosław, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
    Conference:
    19th International Congress of Young Medical Scientists (rok: 2019, ), Wydawca: Uniwersytet Medyczny w Poznaniu
    Data:
    konferencja 43615
    Status:
    Published
  8. Novel synthetic derivatives of oleanolic acid conjugated with diclofenac modulate Nrf2-ARE signaling pathway in pancreatic cancer cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Robert Kleszcz, Wanda Baer-Dubowska
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: FEBS Open BIO
    Data:
    konferencja 43652
    Status:
    Published
  9. Diclofenac hybrids with oleanolic acid oximes modulate key signaling pathways in pancreatic cancer cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Wanda Baer-Dubowska
    Conference:
    AACR Annual Meeting 2022 (rok: 2022, ), Wydawca: AACR
    Data:
    konferencja April 8-13, 2022
    Status:
    Accepted for publication
  10. Morpholide and methyl ester oleanolic acid oxime derivatives and their conjugates with aspirin modulate the cell cycle, proliferation and apoptosis in HepG2 hepatoma cells.
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
    Conference:
    XXIIIrd Gliwice Scientific Meeting, Gliwice, November 22-23,2019 (rok: 2019, ), Wydawca: B.m. 2019
    Data:
    konferencja 43791
    Status:
    Published
  11. Conjugation of indomethacin with novel oleanolic acid oximes increases its Nrf2 and NF-κB signaling pathways modulating effect in pancreatic cancer cells
    Authors:
    Wanda Baer-Dubowska, Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar
    Conference:
    AACR Annual Meeting 2021 (rok: 2021, ), Wydawca: AACR
    Data:
    konferencja April 10-15 and May 17-21 2021
    Status:
    Published
  12. NOVEL OLEANOLIC ACID OXIMES CONJUGATED WITH IBUPROFEN AND KETOPROFEN DOWNREGULATE THE NRF2- ARE SIGNALING PATHWAY IN HUMAN HEPATOCELLULAR CANCER CELLS IN CONTRAST TO NORMAL HEPATOCYTES
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
    Conference:
    XXIV Gliwice Scientific Meeting (rok: 2020, ), Wydawca: B.m.2020
    Data:
    konferencja 20-21 November 2020
    Status:
    Published

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