Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Modified borondipyrromethane derivatives (BODIPY) with selective photodynamic activity against cancer and bacterial cells

2016/21/D/NZ7/01540

Keywords:

BODIPY photodynamic therapy cytotoxicity antibacterial drugs cancers antybiotics dypyrromethane

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ6_4: Bacteriology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jarosław Piskorz 

Number of co-investigators in the project: 6

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 862 450 PLN

Project start date (Y-m-d): 2017-02-06

Project end date (Y-m-d): 2022-02-05

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do chromatografii Flash z detektorem mas (np. CombiFlash RF+ PurIon, PuriFlash TM215 MS) (490 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (11)
  1. BODIPY-Based Photosensitizers as Potential Anticancer and Antibacterial Agents: Role of the Positive Charge and the Heavy Atom Effect
    Authors:
    Jaroslaw Piskorz, Weronika Porolnik, Malgorzata Kucinska, Jolanta Dlugaszewska, Marek Murias, Jadwiga Mielcarek
    Academic press:
    ChemMedChem (rok: 2021, tom: 16, strony: 399-411), Wydawca: Chemistry Europe
    Status:
    Published
    DOI:
    10.1002/cmdc.202000529 - link to the publication
  2. Boron-dipyrromethene derivatives bearing N-alkyl phthalimide and amine substituents of potential application in the photoinactivation of bacteria
    Authors:
    Jaroslaw Piskorz, Jolanta Dlugaszewska, Weronika Porolnik, Anna Teubert, Jadwiga Mielcarek
    Academic press:
    Dyes and Pigments (rok: 2020, tom: 178, strony: 108322 (1-9)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2020.108322 - link to the publication
  3. Tuning photodynamic properties of BODIPY dyes, porphyrins' little sisters
    Authors:
    Wojciech Krzemień, Monika Rohlickova, Miloslav Machacek, Veronika Novakova, Jarosław Piskorz, Petr Zimcik
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 4194 (1-18)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26144194 - link to the publication
  4. Photochemical Properties and Stability of BODIPY Dyes
    Authors:
    Patryk Rybczynski, Aleksander Smolarkiewicz-Wyczachowski, Jaroslaw Piskorz, Szymon Bocian, Marta Ziegler-Borowska, Dariusz Kedziera, Anna Kaczmarek-Kedziera
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6735 (1-22)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136735 - link to the publication
  5. Serendipitous synthesis of unsymmetrical porphyrazine: Incomplete transesterification during macrocyclization
    Authors:
    Weronika Porolnik, Monika Kasprzycka, Anna Teubert, Jaroslaw Piskorz
    Academic press:
    Inorganic Chemistry Communications (rok: 2021, tom: 133, strony: 108953 (1-5)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.inoche.2021.108953 - link to the publication
  1. Development of the novel boron-dipyrromethene derivatives of potential application in the photodynamic therapy
    Authors:
    Porolnik W., Podciechowska K., Wieczorek E., Krzemień W., Teubert A., Mielcarek J., Piskorz J.
    Conference:
    Chemistry Beyond Nature (rok: 2018, ), Wydawca: Cursiva
    Data:
    konferencja 21-22.06.2018
    Status:
    Published
  2. Novel BODIPYs with dimethylamine substituents and their cationic and iodinated derivatives for anticancer and antibacterial photodynamic therapy
    Authors:
    Porolnik W., Kucinska M., Dlugaszewska J., Murias M., Mielcarek J., Piskorz J.
    Conference:
    6th International Electronic Conference on Medicinal Chemistry (rok: 2020, ), Wydawca: sciforum
    Data:
    konferencja 01.11-30.11
    Status:
    Published
  3. Synthesis, photochemical and antimicrobial studies of novel BODIPY-based photosensitizers with various alkylamine substituents
    Authors:
    Piskorz J., Porolnik W., Dlugaszewska J., Teubert A., Mielcarek J.
    Conference:
    11th International Conference on Porphyrins and Phthalocyanines ICPP-11 (rok: 2021, ), Wydawca: Society of Porphyrins & Phthalocyanines
    Data:
    konferencja 44344
    Status:
    Published
  4. Boron-dipyrromethene (BODIPY) derivatives bearing N-alkyl phthalimide and amine substituents of potential application in the photoinactivation of bacteria
    Authors:
    Piskorz J., Dlugaszewska J., Gdaniec Z., Mielcarek J.
    Conference:
    Annual Congress of the Italian Society of Photobiology – SIFB2019 (rok: 2019, ), Wydawca: Società Italiana di Fotobiologia
    Data:
    konferencja 43635
    Status:
    Published
  5. In vitro photodynamic antimicrobial activity of novel boron-dipyrromethene derivatives substituted with various alkylamine substituents
    Authors:
    Piskorz J., Porolnik W., Dlugaszewska J., Mielcarek J.
    Conference:
    18th Blue Danube Symposium on Heterocyclic Chemistry (rok: 2019, ), Wydawca: University of Ljubljana Faculty of Chemistry and Chemical Technology
    Data:
    konferencja 43726
    Status:
    Published
  6. Novel boron-dipyrromethene derivatives as potential photosensitizers for the photodynamic therapy
    Authors:
    Porolnik W., Podciechowska K., Teubert A., Mielcarek J., Piskorz. J
    Conference:
    IX Konwersatorium Chemii Medycznej (rok: 2018, ), Wydawca: IX Konwersatorium Chemii Medycznej
    Data:
    konferencja 13-15.09.2018
    Status:
    Published
  7. In vitro photodynamic antimicrobial activity of novel boron-dipyrromethene derivatives with aliphatic tertiary and quaternary amino substituents
    Authors:
    Porolnik W., Długaszewska J., Mielcarek J., Piskorz J.
    Conference:
    Annual Congress of the Italian Society of Photobiology – SIFB2019 (rok: 2019, ), Wydawca: Società Italiana di Fotobiologia
    Data:
    konferencja 43635
    Status:
    Published
  8. Novel BODIPY derivatives possessing aliphatic tertiary and quaternary amine groups as efficient anticancer and antibacterial photosensitizers
    Authors:
    Porolnik W., Kucinska M., Dlugaszewska J., Murias M., Mielcarek J., Piskorz J.
    Conference:
    XXXII Annual Conference of the Italian Society of Photobiology SIFB 2021 (rok: 2021, ), Wydawca: Società Italiana di Fotobiologia
    Data:
    konferencja 44370
    Status:
    Published
  9. Novel BODIPYs with strong heavy atom effect as dual photosensitizers for antimicrobial and anticancer PDT
    Authors:
    Porolnik W., Kucinska M., Dlugaszewska J., Murias M., Mielcarek J., Piskorz J.
    Conference:
    1st HighLIGHTing Science Meeting & PANIC 2021 (rok: 2021, ), Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
    Data:
    konferencja 44342
    Status:
    Published
  10. Novel dipyrrole and tetrapyrrole-based photosensitizers with various biphenylmethyl substituents of potential application in PDT
    Authors:
    Porolnik W., Podciechowska K., Kasprzycka M., Foltynowicz M., Górzna N., Maćkowiak A., Karpińska N., Teubert A., Piskorz J.
    Conference:
    XXXII Annual Conference of the Italian Society of Photobiology SIFB 2021 (rok: 2021, ), Wydawca: Società Italiana di Fotobiologia
    Data:
    konferencja 44370
    Status:
    Published
  11. Synthesis of phthalimide sulfanyl porphyrazines and their optical properties
    Authors:
    Michal Falkowski a , Lukasz PopeFalkowski M., Popenda L., Piskorz J., Wieczorek E., Jurga S., Marszall M.P., Mieszkowski D., Mielcarek J., Goslinski T.
    Conference:
    NanoTech Poland 2018 & 1st Symposium on Polydopamine (rok: 2018, ), Wydawca: NanoTech Poland 2018 & 1st Symposium on Polydopamine
    Data:
    konferencja 06-09.06.2018
    Status:
    Published

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