Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Targeting Nrf2-ARE pathway for chemoprevention and /or therapy of the liver and the pancreas cancers by naturally occurring phytochemicals

2016/21/B/NZ5/01390

Keywords:

Nrf2 NF-kB p53 phytochemicals liver and pancreas cancers

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Violetta Krajka-Kuźniak 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 918 140 PLN

Project start date (Y-m-d): 2017-02-13

Project end date (Y-m-d): 2022-02-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Analizator systemowy Chemi DocTM (140 000 PLN)
  2. Komputer z oprogramowaniem do analizy statystycznej (4 500 PLN)
  3. Analizator komórek Muse (TM) (55 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (9)
  1. Comparison of the impact of xanthohumol and phenethyl isothiocyanate and their combination on Nrf2 and NF-κB pathways in HepG2 cells in vitro and tumor burden in vivo.
    Authors:
    M. Cykowiak, V. Krajka-Kuźniak, R. Kleszcz, M. Kucińska, H. Szaefer, H. Piotrowska-Kempisty, A. Plewiński, M. Murias, W. Baer-Dubowska
    Academic press:
    Nutrients (rok: 2021, tom: 13, strony: 28), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu13093000 - link to the publication
  2. Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-kB and activates Nrf2 in pancreatic cancer cells
    Authors:
    V. Krajka-Kuźniak, M. Cykowiak, H. Szaefer, R. Kleszcz, W. Baer-Dubowska
    Academic press:
    Toxicology in Vitro (rok: 2020, tom: 65, strony: 104799), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2020.104799 - link to the publication
  3. Modulation of Nrf2 and NF-kB singaling pathways by naturally occurring compounds in relation to cancer prevention and therapy. Are combinations better than single compounds?
    Authors:
    V. Krajka-Kuźniak, W. Baer-Dubowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 8223), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22158223 - link to the publication
  4. Attenuation of pancreatic cancer in vitro and in vivo via modulation of Nrf2 and NF-κB signaling pathways by natural compounds.
    Authors:
    M. Cykowiak, R. Kleszcz, M. Kucińska, J. Paluszczak, H. Szaefer, A. Plewiński, H. Piotrowska-Kempisty, M. Murias, V. Krajka-Kuźniak
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 31), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  5. Role of Nrf2 in pancreatic cancer.
    Authors:
    M. Cykowiak, V. Krajka-Kuźniak
    Academic press:
    Antioxidants (Basel) (rok: 2021, tom: 11, strony: 19), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  6. Phytochemical combinations modulate the activation of Nrf2 and expression of SOD in pancreatic cancer cells more efficiently than single plant components
    Authors:
    V. Krajka-Kuźniak, M. Cykowiak, W. Baer-Dubowska
    Academic press:
    Proceedings (rok: 2019, tom: 11, strony: 45295), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/proceedings2019011022 - link to the publication
  7. Nrf2 as therapeutic target in prevention and therapy of civilization diseases
    Authors:
    M. Cykowiak, V. Krajka-Kuźniak
    Academic press:
    Farmacja Współczesna (rok: 2019, tom: 12, strony: 42-49), Wydawca: Akademia Medycyny
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Combinatorial treatment with phytochemicals modulate Nrf2 signaling pathway, but not affect proliferation and cell cycle in HEPA1-6 cell line
    Authors:
    M. Cykowiak, H. Szaefer, R. Kleszcz, V. Krajka-Kuźniak
    Conference:
    19th International Congress of Young Medical Scientists (rok: 2019, ), Wydawca: Uniwersytet Medyczny w Poznaniu
    Data:
    konferencja 43615
    Status:
    Published
  2. Modulation of the Nrf2 signaling pathways by a combination of phytochemicals in human hepatocellular carcinoma cells
    Authors:
    M. Cykowiak, J. Paluszczak, H. Szaefer, V. Krajka-Kuźniak
    Conference:
    XXI Gliwice Scientific Meetings 2017 (rok: 2017, ), Wydawca: Instytut Onkologii im. Marii Skłodowskiej-Curie, Gliwice, Śląski Uniwersytet Techniczny
    Data:
    konferencja 17-18/11/2017
    Status:
    Published
  3. Phytochemicals and their combinations affect the cell cycle, apoptosis and proliferation of HepG2 cells with different efficiency
    Authors:
    M. Cykowiak, V. Krajka-Kuźniak, R. Kleszcz
    Conference:
    XXIV Gliwice Scientific Meetings 2020 (rok: 2020, ), Wydawca: http://gsn.io.gliwice.pl/
    Data:
    konferencja 20-21/11/2020
    Status:
    Published
  4. The effect of phytochemicals and their combination on the expression and activity of Nrf2 in human pancreatic cancer cells
    Authors:
    M. Cykowiak, H. Szaefer, V. Krajka-Kużniak
    Conference:
    Congress BIO 2018; 51th Meeting of the Polish Biochemical Society; 14th Conference of the Polish Society for Cell Biology (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21/09/2018
    Status:
    Published
  5. Modulation of NF-KB and STATs signaling pathways by selected phytochemicals and their combinations in human hepatoma HepG2 cells.
    Authors:
    M. Cykowiak, V. Krajka-Kuźniak, W. Baer-Dubowska
    Conference:
    NutRedOx COST Action CA16112 (rok: 2021, ), Wydawca: NutRedOx COST
    Data:
    konferencja 19-21/09/2021
    Status:
    Published
  6. Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB more effectively than single compounds in pancreatic cancer cells.
    Authors:
    M. Cykowiak, V. Krajka-Kuźniak , J. Paluszczak, R. Kleszcz, W. Baer-Dubowska
    Conference:
    45th FEBS Congress "Molecules of Life: Towards New Horizons". Virtual, July 3-8, 2021. (rok: 2021, ), Wydawca: "Molecules of Life: Towards New Horizons". 2021 : Vol. 11, suppl. 1
    Data:
    konferencja 3-8/07/2021
    Status:
    Published
  7. Xanthohumol and phenethyl isothiocyanate combinations is the potent inducer of activation of Nrf2 and expression of antioxidant enzymes in pancreatic cancer cells
    Authors:
    V. Krajka-Kuźniak, M. Cykowiak, W. Baer-Dubowska
    Conference:
    NutRedox (rok: 2019, ), Wydawca: COST ACTION
    Data:
    konferencja 43740
    Status:
    Published
  8. Modulation of the Nrf2 signaling pathway by selected phytochemicals and their combinations in human pancreatic cancer cells
    Authors:
    M. Cykowiak, H. Szaefer, J.Paluszczak, V. Krajka-Kuźniak
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: FEBS Open BIO
    Data:
    konferencja 43652
    Status:
    Published
  9. Ścieżka sygnałowa Nrf2-ARE: nowe mechanizmy regulacji i możliwości wykorzystania w profilaktyce i terapii nowotworów
    Authors:
    W. Baer-Dubowska, V. Krajka-Kuźniak, J. Paluszczak
    Conference:
    XXIII Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego, Kraków (rok: 2017, ), Wydawca: Polskie Towarzystwo Farmaceutyczne, Wydział Farmaceutyczny, Uniwersytet Jagielloński
    Data:
    konferencja 19-22/09/2017
    Status:
    Published

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