Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of novel, synergistic drug combinations for the treatment of B cell malignancies

2016/21/B/NZ7/02041

Keywords:

B cell malignancies therapy non-Hodgkin lymphoma chronic lymphoblastic leukemia thioredoxin reductase

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Firczuk 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 386 300 PLN

Project start date (Y-m-d): 2017-03-06

Project end date (Y-m-d): 2020-03-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Regał do hodowli myszy laboratoryjnych IVC z jednostką nawiewczą (130 000 PLN)
  2. Termoblok z funkcją mieszania (20 000 PLN)
  3. System do elektroporacji komórek eukariotycznych i prokariotycznych.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy
    Authors:
    Firczuk M, Bajor M, Graczyk-Jarzynka A, Fidyt K, Goral A, Zagozdzon R
    Academic press:
    Cancer letters (rok: 2020, tom: 471, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2019.11.037 - link to the publication
  2. Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy
    Authors:
    Antoni Domagala, Klaudyna Fidyt, Malgorzata Bobrowicz, Joanna Stachura, Kacper Szczygiel and Malgorzata Firczuk
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19082256 - link to the publication
  3. Inhibition of thioredoxin-dependent H2O2 removal sensitizes malignant Bcells to pharmacological ascorbate
    Authors:
    Agnieszka Graczyk-Jarzynka, Agnieszka Goral, Angelika Muchowicz, Radoslaw Zagozdzon, Magdalena Winiarska, Malgorzata Bajor, Anna Trzeciecka, Klaudyna Fidyt, Joanna Alicja Krupka, Julia Cyran, Kacper Szczygiel, Dimitar G. Efremov, Stefania Gobessi, Adam Jagielski, Karolina Siudakowska, Malgorzata Bobrowicz, Marta Klopotowska, Joanna Barankiewicz, Agata Malenda, Ewa Lech-Maranda, Nina Miazek-Zapala, Piotr Henryk Skarzynski, Antoni Domagala, Jakub Golab, Malgorzata Firczuk
    Academic press:
    Redox biology (rok: 2018, tom: 101062, strony: 45298), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.redox.2018.11.020 - link to the publication
  4. cROSsing the line: between beneficial and harmful effects of Reactive Oxygen Species in B-cell malignancies
    Authors:
    Domka K, Goral A, Firczuk M
    Academic press:
    Frontiers immunology (rok: 2020, tom: 11, strony: 45299), Wydawca: frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.01538 - link to the publication
  1. Oxidative stress in the microenvironment of B cell chronic lymphocytic leukemia
    Authors:
    M. Firczuk, A. Goral, A. Muchowicz, K. Fidyt, S. Gobessi, D. Efremov
    Conference:
    European Congress of Immunology (rok: 2018, ), Wydawca: ECI2018 and EFIS President's Office
    Data:
    konferencja 2-5 wrzesień
    Status:
    Published

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