Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Creation of immunosuppressive exosomes for the induction of antigen-specific tolerance

2016/21/B/NZ7/02747

Keywords:

exosomes miRNA electroporation transplantation auto-immunity

Descriptors:

  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Markus Düchler 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 679 200 PLN

Project start date (Y-m-d): 2017-02-15

Project end date (Y-m-d): 2020-10-14

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. aparat do elektroporacja (42 200 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. EVs separation: release of intact extracellular vesicles immunocaptured on magnetic particles
    Authors:
    Dario Brambilla, Laura Sola, Anna Ferretti, Elisa Chiodi, Natasa Zarovni, Diogo Fortunato, Mattia Criscuoli, Vincenza Dolo, Ilaria Giusti, Valentina Murdica, Katarzyna Kluszczyńska, Liliana Czernek, Markus Düchler, Riccardo Vago, Marcella Chiari
    Academic press:
    Analytical Chemistry (rok: 2021, tom: 93 (13), strony: 5476-5483), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.analchem.0c05194 - link to the publication
  2. Exosomes as messengers between mother and fetus in pregnancy
    Authors:
    Liliana Czernek and Markus Düchler
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21 (12), strony: 4264), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21124264 - link to the publication
  3. Melanoma-Derived Extracellular Vesicles Bear the Potential for the Induction of Antigen-Specific Tolerance
    Authors:
    Düchler, M; Czernek, L; Peczek, L; Cypryk, W; Sztiller-Sikorska, M; Czyz, M.
    Academic press:
    CELLS (rok: 2019, tom: 8 (7), strony: E665), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8070665 - link to the publication
  4. U6/miR-211 expression ratio as a purity parameter forHEK293 cell-derived exosomes
    Authors:
    Katarzyna Kluszczyńska, Łukasz Pęczek, Artur Różański, Liliana Czernek, and Markus Düchler
    Academic press:
    Acta Biochimica Polonica (rok: 2022, tom: 69, strony: 409-415), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2020_5870 - link to the publication
  5. Methods for the determination of the purity of exosomes
    Authors:
    Kluszczyńska K, Czernek L, Cypryk W, Pęczek Ł, Düchler M.
    Academic press:
    Current Pharmaceutical Design (rok: 2019, tom: 25, strony: 4464-4485), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/1381612825666191206162712 - link to the publication

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