Projects funded by the NCN
Is adipose tissue beneficially involved in lifespan regulation? Analysis of potential mechanisms, mainly the role of GH-IGF-I axis, insulin metabolic pathway and inflammation in long-lived Ames dwarf (df/df) mice
2016/21/B/NZ4/03192
Keywords:
aging adipose tissue lifespan Ames dwarf mice somatotropic signaling inflammation
Descriptors:
- NZ4_12: Other related subjects
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Uniwersytet Medyczny w Łodzi, Wydział Lekarski
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 8
Call: OPUS 11 - announced on 2016-03-15
Amount awarded: 1 381 000 PLN
Project start date (Y-m-d): 2017-01-18
Project end date (Y-m-d): 2022-11-17
Project duration:: 70 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (5)
- Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged miceAuthors:Tatiana Dandolini Saccon, Ravinder Nagpal, Hariom Yadav, Marcelo Borges Cavalcante, Allancer Divino de Carvalho Nunes, Augusto Schneider, Adam Gesing, Brian Hughes, Matthew Yousefzadeh, Tamar Tchkonia, James L. Kirkland, Laura J. Niedernhofer, Paul D. Robbins, Michal M. MasternakAcademic press:J Gerontol A Biol Sci Med Sci (rok: 2021, tom: 76, strony: 1895-1905), Wydawca: Oxford University PressStatus:PublishedDOI:10.1093/gerona/glab002 - link to the publication
- GH deficiency confers protective advantages against Alzheimer's disease through rescued miRNA expression profile in APP/PS1 miceAuthors:Sarah Noureddine, Tatiana Saccon, Trina Rudeski-Rohr, Adam Gesing, Jeffrey B Mason, Augusto Schneider, Joseph Dhabhi, Kendra L Puig, Sharlene Rakoczy, Holly M Brown-Borg, Michal M MasternakAcademic press:Geroscience (rok: 2022, tom: 44, strony: 2885-2893), Wydawca: SpringerStatus:PublishedDOI:10.1007/s11357-022-00633-0 - link to the publication
- The Role of Ames Dwarfism and Calorie Restriction on Gut MicrobiotaAuthors:Denise S. Wiesenborn, Eric J. C. Gálvez, Lina Spinel, Berta Victoria, Brittany Allen, Augusto Schneider, Adam Gesing, Khalid A. Al-Regaiey, Till Strowig, Karl-Herbert Schäfer, Michal M. MasternakAcademic press:J Gerontol A Biol Sci Med Sci (rok: 2020, tom: 75, strony: e1-e8), Wydawca: Oxford University PressStatus:PublishedDOI:10.1093/gerona/glz236 - link to the publication
- Impact of visceral adipose tissue on longevity and metabolic health: a comparative study of gene expression in perirenal and epididymal fat of Ames dwarf mice.Authors:Agnieszka Zaczek, Andrzej Lewiński, Małgorzata Karbownik-Lewińska, Andrea Lehoczki, Adam GesingAcademic press:GeroScience (rok: 2024, ), Wydawca: SpringerStatus:Accepted for publicationDOI:10.1007/s11357-024-01131-1 - link to the publication
- Growth hormone signaling shapes the impact of environmental temperature on transcriptomic profile of different adipose tissue depots in male miceAuthors:Augusto Schneider, Berta Victoria, Maria Isabel Schiavon Cousen, Yimin Fang, Samuel McFadden, Justin Darcy, Adam Gesing, Erin R. Hascup, Kevin N. Hascup, Andrzej Bartke, Michal M. MasternakAcademic press:J Gerontol A Biol Sci Med Sci (rok: 2022, tom: 77, strony: 941-946), Wydawca: Oxford University PressStatus:PublishedDOI:10.1093/gerona/glab291 - link to the publication