Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New functional links in eukaryotic cell: Vesicular trafficking is a genome stability guardian.

2016/21/B/NZ3/03641

Keywords:

genome instability ploidy shift cell cycle genotoxic stress response intracellular traficking

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology
  • NZ2_1: Molecular genetics

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Adrianna Skoneczna 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 069 400 PLN

Project start date (Y-m-d): 2017-03-07

Project end date (Y-m-d): 2021-03-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Ekran BAS-IP MS 2040 E do fosfoimagera wraz z kasetą, 200x400 mm (8 000 PLN)
  2. Zestaw umożliwiający analizę elektroforetyczną DNA pojedynczych komórek (8 900 PLN)
  3. Oprogramowanie do analizy wyników testów kometkowych (26 800 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (14)
  • Book publications / chapters in book publications (2)
  1. Lack of G1/S control destabilizes the yeast genome via replication stress-induced DSBs and illegitimate recombination
    Authors:
    Kamil Krol, Justyna Antoniuk-Majchrzak, Marek Skoneczny, Marzena Sienko, Justyna Jendrysek, Izabela Rumienczyk, Agnieszka Halas, Anna Kurlandzka, Adrianna Skoneczna
    Academic press:
    Journal of Cell Science (rok: 2018, tom: 131(24), strony: jcs226480), Wydawca: The Company of Biologists Ltd
    Status:
    Published
    DOI:
    10.1242/jcs.226480 - link to the publication
  2. Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO
    Authors:
    Justyna Antoniuk-Majchrzak, Tuguldur Enkhbaatar, Anna Długajczyk, Joanna Kaminska, Marek Skoneczny, Daniel J. Klionsky, Adrianna Skoneczna
    Academic press:
    Biochimica et Biophysica Acta - Molecular Cell Research (rok: 2023, tom: 1870(7), strony: 119526), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2023.119526 - link to the publication
  3. Live while the DNA lasts. The role of autophagy in DNA loss and survival of diploid yeast cells during chronological aging
    Authors:
    Tuguldur Enkhbaatar, Marek Skoneczny, Karolina Stępień, Mateusz Mołoń, Adrianna Skoneczna
    Academic press:
    Aging-US (rok: 2023, ), Wydawca: IMPACT JOURNALS LLC
    Status:
    Submitted
    DOI:
    praca - link to the publication
  1. Intracellular level of S. cerevisiae Rad51 is regulated via Ubi-dependent proteolysis
    Authors:
    Adrianna Skoneczna
    Conference:
    11th Central European Genome Stability and Dynamics Meeting (rok: 2021, ), Wydawca: University of Szeged
    Data:
    konferencja 23-24 marca 2021
    Status:
    Published
  2. The SRS2 mRNA colocalizes with P-bodies and stress granules during genotoxic and replication stress
    Authors:
    Tuguldur Enkhbaatar
    Conference:
    11th Central European Genome Stability and Dynamics Meeting (rok: 2021, ), Wydawca: University of Szeged
    Data:
    konferencja 23-24 marca 2021
    Status:
    Published
  3. Unperturbed vesicular trafficking ensures efficient DNA damage response
    Authors:
    Długajczyk Anna, Król Kamil, Skoneczny Marek, Skoneczna Adrianna
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (rok: 2018, ), Wydawca: IBB PAN
    Data:
    konferencja 13-14 września
    Status:
    Published
  4. Malfunctions of the vesicular trafficking affect the post-translational modifications status, activity, and localization of DNA repair proteins
    Authors:
    Anna Długajczyk, Kamil Król, Adrianna Skoneczna, Marek Skoneczny
    Conference:
    11th Central European Genome Stability and Dynamics Meeting (rok: 2021, ), Wydawca: University of Szeged
    Data:
    konferencja 23-24 marca 2021
    Status:
    Published
  5. The checkpoint activation in replication deficient mutants is rescued in temperature-dependent manner
    Authors:
    Antoniuk-Majchrzak Justyna, Denkiewicz-Kruk Milena, Jędrychowska Małgorzata, Długajczyk Anna, Król Kamil, Dmowski Michał, Skoneczny Marek, Skoneczna AdriannaInstitute
    Conference:
    10th Inhibitors of Protein Kinases Conference (rok: 2019, ), Wydawca: Komitet Organizacyjny IPK 2019
    Data:
    konferencja 43722
    Status:
    Published
  6. Vesicular trafficking contribution to genome maintenance
    Authors:
    Anna Długajczyk, Kamil Król, Marek Skoneczny, Adrianna Skoneczna
    Conference:
    10th Central European Genome Stability and Dynamics Meeting (rok: 2019, ), Wydawca: Komitet Organizacyjny 10th CEGSDM
    Data:
    konferencja 43734
    Status:
    Published
  7. Inefficient DNA damage signaling contribute to genome instability of Saccharomyces cerevisiae swi6Δ cells
    Authors:
    Antoniuk-Majchrzak J., Krol K., Kurlandzka A., Skoneczny M., Skoneczna A.
    Conference:
    10th Central European Genome Stability and Dynamics Meeting (rok: 2019, ), Wydawca: Komitet Organizacyjny 10th CEGSD
    Data:
    konferencja 43734
    Status:
    Published
  8. Saccharomyces cerevisiae cells lacking SWI6 gene are genetically unstable
    Authors:
    Antoniuk-Majchrzak Justyna, Król Kamil, Skoneczny Marek, Kurlandzka Anna, Skoneczna Adrianna
    Conference:
    28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB) (rok: 2017, ), Wydawca: Institute of Microbiology of the Czech Academy of Sciences
    Data:
    konferencja 27.08-1.09
    Status:
    Published
  9. Defects in Vesicular Trafficking Leads to Loss of Genome Integrity
    Authors:
    Skoneczna Adrianna, Długajczyk Anna, Król Kamil, Skoneczny Marek
    Conference:
    The 35th International Specialized Symposium on Yeasts (rok: 2019, ), Wydawca: Cukurova University
    Data:
    konferencja 43759
    Status:
    Published
  10. Lack of G1/S control destabilizes the yeast genome via replication stress-induced DSBs and Rad51p-mediated illegitimate recombination
    Authors:
    Antoniuk-Majchrzak Justyna, Król Kamil, Skoneczny Marek, Sieńko Marzena, Jędrysek Justyna, Rumieńczyk Izabela, Hałas Agnieszka, Kurlandzka Anna, Skoneczna Adrianna
    Conference:
    9th Central Europea Genome Stability and Dynamics Meeting (rok: 2018, ), Wydawca: IBB PAN
    Data:
    konferencja 13-14 września
    Status:
    Published
  11. Efficient Vesicular Trafficking Protects Yeast Saccharomyces cerevisiae Genome from Fragmentation
    Authors:
    Anna Długajczyk, Kamil Krol, Marek Skoneczny and Adrianna Skoneczna
    Conference:
    XXIX International Conference on Yeast Genetics and Molecular Biology (rok: 2019, ), Wydawca: Komitet Organizacyjny ICYGMB 2019
    Data:
    konferencja 43695
    Status:
    Published
  12. Lack of G1/S control in swi6Δ mutants destabilizes the budding yeast genome through replication stress-induced DSBs and Rad51p-mediated illegitimate recombination
    Authors:
    Antoniuk-Majchrzak Justyna, Król Kamil, Skoneczny Marek, Sieńko Marzena, Jędrysek Justyna, Rumieńczyk Izabela, Hałas Agnieszka, Kurlandzka Anna, Skoneczna Adrianna
    Conference:
    Keystone Symposia - DNA Replication and Genome Instability: From Mechanism to Disease (rok: 2019, ), Wydawca: Komitet Organizacyjny Keystone Symposia
    Data:
    konferencja 43478
    Status:
    Published
  13. Loss of Control at G1/S Phase Border of Cell Cycle in swi6Δ Cells of S. cerevisiae Leads to Genome Instability through Replication Stress-induced DSBs and Rad51-mediated Illegitimate Recombination
    Authors:
    Adrianna Skoneczna, Justyna Antoniuk-Majchrzak, Kamil Krol, Marzena Sieńko, Anna Kurlandzka and Marek Skoneczny
    Conference:
    XXIX International Conference on Yeast Genetics and Molecular Biology (rok: 2019, ), Wydawca: Komitet Organizacyjny ICYGMB 2019
    Data:
    konferencja 43695
    Status:
    Published
  14. Uncovering Las17 secret service in nucleolus
    Authors:
    Skoneczna Adrianna, Krol Kamil, Skoneczny Marek, Kaminska Joanna, Kurlandzka Anna
    Conference:
    28th International Conference on Yeast Genetics and Molecular Biology (ICYGMB) (rok: 2017, ), Wydawca: Institute of Microbiology of the Czech Academy of Sciences
    Data:
    konferencja 27.08 – 1.09
    Status:
    Published
  1. Response Mechanisms to Chemical and Physical Stresses in Yeast and Filamentous Fungi
    Authors:
    Marek Skoneczny, Adrianna Skoneczna
    Book:
    Stress Response Mechanisms in Fungi: Theoretical and Practical Aspects (rok: 2018, tom: 1, strony: 35-86), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
  2. How Do Yeast and Other Fungi Recognize and Respond to Genome Perturbations?
    Authors:
    Adrianna Skoneczna, Kamil Król, Marek Skoneczny
    Book:
    Stress Response Mechanisms in Fungi: Theoretical and Practical Aspects (rok: 2018, tom: 1, strony: 87-130), Wydawca: Springer Nature Switzerland AG
    Status:
    Published

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