Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The application of the yeast model to investigate the genotoxic properties of antimony

2016/21/B/NZ2/01751

Keywords:

antimony toxic metalloid yeast Saccharomyces cerevisiae DNA damage DNA repair

Descriptors:

  • NZ2_1: Molecular genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Robert Wysocki 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 673 420 PLN

Project start date (Y-m-d): 2017-02-09

Project end date (Y-m-d): 2021-02-08

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do elektroforezy kwasów nukleinowych (7 500 PLN)
  2. Zestaw do elektroforezy i transferu (9 500 PLN)
  3. Inkubator z wytrząsaniem (15 000 PLN)
  4. Piec do hybrydyzacji (13 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Book publications / chapters in book publications (1)
  1. Complex Mechanisms of Antimony Genotoxicity in Budding Yeast Involves Replication and Topoisomerase I-Associated DNA Lesions, Telomere Dysfunction and Inhibition of DNA Repair
    Authors:
    Ireneusz Litwin, Seweryn Mucha, Ewa Pilarczyk, Robert Wysocki, Ewa Maciaszczyk-Dziubinska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4510 (1-30)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094510 - link to the publication
  2. Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony
    Authors:
    Robert Wysocki, Joana I. Rodrigues, Ireneusz Litwin, Markus J. Tamás
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2023, tom: 80, strony: 342 (1-30)), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
    DOI:
    10.1007/s00018-023-04992-5 - link to the publication
  1. Chapter 12 Molecular mechanisms of antimony transport and detoxification
    Authors:
    Robert Wysocki
    Book:
    Antimony (rok: 2021, tom: Brak, strony: 275-302), Wydawca: Berlin, Boston: De Gruyter
    Status:
    Published

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