Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Epitope mapping of Clostridium difficile surface proteins with characteristics of protective properties of epitope conjugated with carrier protein in combination with novel nanoadjuvant.

2016/21/B/NZ6/02286

Keywords:

antigen vaccine umbilical cord blood Clostridium difficile infection

Descriptors:

  • NZ6_4: Bacteriology
  • NZ6_8: Other related subjects
  • NZ7_12: Prevention of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Gamian 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 766 580 PLN

Project start date (Y-m-d): 2017-02-17

Project end date (Y-m-d): 2021-02-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikser laboratoryjny (15 000 PLN)
  2. Odwrócony mikroskop biologiczny z komputerem i oprogramowaniem (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. The Bioinformatic and In Vitro Studies of Clostridioides Difficile Aminopeptidase M24 Revealed the Immunoreactive KKGIK Peptide
    Authors:
    Pacyga K., Razim A., Martirosian G., Aptekorz M., Szuba A., Gamian A., Myc A., Górska S.
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1146), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9051146 - link to the publication
  2. Flagellar proteins as candidate vaccine antigens: identification of Clostridioides difficile FliC and FliD linear epitopes using patients' serum antibodies
    Authors:
    Razim A., Pacyga K., Naporowski P., Martynowski D., Szuba A., Gamian A., Górska S.
    Academic press:
    Scientific Reports (rok: 2021, tom: 11(1), strony: 45304), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-89488-7 - link to the publication
  3. Mapping Epitopes of a Novel Peptidoglycan Cross-Linking Enzyme Cwp22 Recognized by Human Sera Obtained from Patients with Clostridioides difficile Infection and Cord Blood
    Authors:
    Razim Agnieszka, Pacyga Katarzyna, Martirosian Gajene, Szuba Andrzej, Gamian Andrzej, Myc Andrzej, Górska Sabina
    Academic press:
    Microorganisms (rok: 2019, tom: 7, strony: 565), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/microorganisms7110565 - link to the publication
  4. Epitopes identified in GAPDH from Clostridium difficile recognized as common antigens with potential autoimmunizing properties
    Authors:
    Agnieszka Razim, Katarzyna Pacyga, Małgorzata Aptekorz, Gayane Martirosian, Andrzej Szuba, Edyta Pawlak-Adamska, Monika Brzychczy-Włoch, Andrzej Myc, Andrzej Gamian, Sabina Górska
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 13946), Wydawca: Springer Nature Publishing AG
    Status:
    Published
    DOI:
    10.1038/s41598-018-32193-9 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy