Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Hyperhomocysteinemia, brain proteom chganges, cognitive function and aging in mice.

2016/21/D/NZ4/00478

Keywords:

homocysteine hyperhomocysteinemia proteom mice models brain cognitive function aging autophagy

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ2_3: Proteomics
  • NZ4_7: Neurophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Suszyńska-Zajczyk 

Number of co-investigators in the project: 3

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 823 840 PLN

Project start date (Y-m-d): 2017-02-08

Project end date (Y-m-d): 2022-02-07

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (12)
  1. A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease
    Authors:
    Anna Kotowska-Zimmer, Lukasz Przybyl, Marianna Pewinska, Joanna Suszynska-Zajczyk, Dorota Wronka, Maciej Figiel, Marta Olejniczak
    Academic press:
    Molecular Therapy Nucleic Acids (rok: 2022, tom: 28, strony: 702-715), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtn.2022.04.031 - link to the publication
  2. Insights into RNA-mediated pathology in new mouse models of Huntington's disease
    Authors:
    Magdalena Wozna-Wysocka, Magdalena Jazurek-Ciesiolka, Lukasz Przybyl, Dorota Wronka, Julia Oliwia Misiorek, Joanna Suszynska-Zajczyk, Grzegorz Figura, Adam Ciesiolka, Paula Sobieszczanska, Anna Zeller, Magdalena Niemira, Pawel Michal Switonski, Agnieszka Fiszer
    Academic press:
    FASEB Journal , Wydawca: Wiley
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Diet-induced hyperhomocysteinemia causes sex-dependent deficiencies in offspring musculature and brain function
    Authors:
    Joanna Suszyńska-Zajczyk, Łukasz Witucki, Joanna Perła-Kaján, Hieronim Jakubowski
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2024, tom: 12, strony: n/a), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcell.2024.1322844. - link to the publication
  1. Dietary hyperhomocysteinemia accelerates neurodegeneration by upregulating mTOR signaling and impairing autophagy in the mouse brain
    Authors:
    Joanna Suszyńska-Zajczyk, and Hieronim Jakubowski
    Conference:
    The Third Annual Rutgers BHI Symposium, Branchburg, NJ, USA (rok: 2017, ), Wydawca: Rutgers
    Data:
    konferencja 1 grudnia 2017.
    Status:
    Published
  2. Phf8-mediated epigenetic dysregulation of mTOR/autophagy increases amyloid beta accumulation and cognitive deficits in hyperhomocysteinemic and bleomycin hydrolase-deficient mice
    Authors:
    Witucki Ł, Suszyńska-Zajczyk J, Wróblewski J, Jakubowski H
    Conference:
    13th International Conference on One-Carbon Metabolism, B Vitamins and Homocysteine (rok: 2021, ), Wydawca: Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu
    Data:
    konferencja 12-16.09.2021
    Status:
    Published
  3. H4K20me1-mediated epigenetic dysregulation of mTOR/autophagy increases amyloid beta accumulation and cognitive/neuromotor deficits in hyperhomocysteinemic and bleomycin hydrolase- deficient mice
    Authors:
    Witucki Ł, Suszyńska-Zajczyk J, Wróblewski J, Jakubowski H
    Conference:
    AAT-AD/PD™ Advances in Alzheimer's Therapies Focus Meeting, AD/PD (rok: 2022, ), Wydawca: Kenes Group
    Data:
    konferencja 15-20.03.2022
    Status:
    Published
  4. Hyperhomocysteinemia during pregnancy causes neurological deficiencies in musculature and brain function in neonatal pups
    Authors:
    Suszyńska-Zajczyk J, Jakubowski H.
    Conference:
    Homocysteine Mini-Conference (rok: 2019, ), Wydawca: Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu
    Data:
    konferencja 43734
    Status:
    Published
    DOI:
    link to the publication
  5. Phf8-mediated epigenetic dysregulation of mTOR signaling/autophagy increases amyloid beta levels and accelerates neurodegeneration in hyperhomocysteinemic and bleomycin hydrolase-deficient mice
    Authors:
    Witucki Ł., Suszyńska-Zajczyk J., Wróblewski J., Jakubowski H.
    Conference:
    Homocysteine Mini-Conference (rok: 2019, ), Wydawca: Wydawnictwo Uniwersytetu Przyrodniczego
    Data:
    konferencja 26 września 2019
    Status:
    Published
    DOI:
    link to the publication
  6. Silencing Cbs or Blmh gene promotes accumulation of amyloid beta via the Phf8/H4K20me1/mTOR/autophagy pathway in mouse neuroblastoma N2A- APPswe cells.
    Authors:
    Witucki Ł, Suszyńska-Zajczyk J, Jakubowski H
    Conference:
    Homocysteine Mini-Conference (rok: 2020, ), Wydawca: Wydawnictwo Uniwersytetu pPrzyrodniczego w Poznaniu
    Data:
    konferencja 25 września 2020
    Status:
    Published
    DOI:
    link to the publication
  7. Dietary hyperhomocysteinemia reduces brain AQP4 expression and cognitive performance in old mice.
    Authors:
    Joanna Suszyńska-Zajczyk, Joanna Śliwowska and Hieronim Jakubowski
    Conference:
    13th International Congress of the Polish Neuroscience Society (rok: 2017, ), Wydawca: Acta Neurobiologiae Experimentalis (suplement 1, vol. 77)
    Data:
    konferencja 28-30 sierpnia 2017
    Status:
    Published
  8. Prenatal hyperhomocysteinemia upregulates mTOR signaling, downregulates autophagy, and increases accumulation of amyloid beta and tau in adult 3xTG-AD mice
    Authors:
    Suszyńska-Zajczyk J, Witucki Ł, Jakubowski H
    Conference:
    13th International Conference on One-Carbon Metabolism, B Vitamins and Homocysteine (rok: 2021, ), Wydawca: Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu
    Data:
    konferencja 12-16.09.2021
    Status:
    Published
  9. Hyperhomocysteinemia causes cognitive impairment by hyper-activating mTOR and impairing autophagy via the inhibition of Phf8 histone demethylase in mice
    Authors:
    Łukasz Witucki, Joanna Suszyńska-Zajczyk, Jacek Wróblewski, Robert Filipkowski, Hieronim Jakubowski
    Conference:
    Folic Acid, Vitamin B12, and One-Carbon Metabolism (rok: 2018, ), Wydawca: FASEB
    Data:
    konferencja 29 lipca-3 sierpnia 2018
    Status:
    Published
  10. Dietary hyperhomocysteinemia accelerates neurodegeneration by upregulating mTOR signaling and impairing autophagy in the mouse brain
    Authors:
    Joanna Suszyńska-Zajczyk, Jacek Wróblewski, Robert J Filipkowski, Hieronim Jakubowski.
    Conference:
    Advances in Alzheimer's and Parkinson's Therapies an ATT-AD/PD Focus Meeting (rok: 2018, ), Wydawca: Kenes Group
    Data:
    konferencja 15-18 March 2018
    Status:
    Published
  11. Hyperhomocysteinemia causes cognitive impairment by hyper-activating mTOR and impairing autophagy via the inhibition of Phf8 histone demethylase in mice
    Authors:
    Łukasz Witucki, Joanna Suszyńska-Zajczyk, Jacek Wróblewski, Robert K Filipkowski, Hieronim Jakubowski
    Conference:
    Fourth Annual Rutgers Brain Health Institute Symposium (rok: 2018, ), Wydawca: Rutgers
    Data:
    konferencja 30 listopada 2018
    Status:
    Published
  12. Neurodegeneration, brain mTOR signaling, and autophagy in a mouse model of dietary hyperhomocysteinemia.
    Authors:
    Joanna Suszyńska-Zajczyk, and Hieronim Jakubowski
    Conference:
    EMBO Conferece: Autophagy: From molecular principles to human diseases (rok: 2017, ), Wydawca: EMBO
    Data:
    konferencja 25 – 29 września 2017
    Status:
    Published

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