Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Modifications of betulin A ring in the synthesis of cytotoxic derivatives.

2016/21/B/ST5/02141

Keywords:

lupanes betulin glycosylation saponins biological activity

Descriptors:

  • ST5_23:
  • ST5_20:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Organicznej Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Zbigniew Pakulski 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 796 000 PLN

Project start date (Y-m-d): 2017-01-18

Project end date (Y-m-d): 2021-01-17

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Autoklawy z wyposażeniem (nisko- i wysokociśnieniowy). (2 szt.) (33 000 PLN)
  2. Mieszadła magnetyczne i mieszadła magnetyczne z kontrolerem temperatury. (4 szt.) (9 317 PLN)
  3. Waga analityczna z jonizatorem antystatycznym. (9 000 PLN)
  4. Zestaw komputerowy + oprogramowanie. (4 000 PLN)
  5. Blok grzewczy aluminiowy (1 028 PLN)
  6. Pompy strzykawkowe z wyposażeniem. (3 szt.) (12 000 PLN)
  7. Wyparka z oprzyrządowaniem. (26 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Book publications / chapters in book publications (1)
  1. Rearrangements of betulin core. Synthesis of terpenoids possessing the bicyclo[3.3.1]nonane fragment by rearrangement of lupane-type epoxides
    Authors:
    Pakulski, Z.; Cmoch, P.; Korda, A.; Luboradzki, R.; Gwardiak, K.; Karczewski, R.
    Academic press:
    J. Org. Chem. (rok: 2021, tom: 86, strony: 1084-1095), Wydawca: AMER CHEMICAL SOC
    Status:
    Published
    DOI:
    10.1021/acs.joc.0c02560 - link to the publication
  2. Oxidative functionalization of trinor-18α-olean-17(22)-ene derivatives. Annulation of the E-ring by an intramolecular aldol reaction
    Authors:
    Kuczynska, K.; Jaźwiński, J.; Pakulski, Z.; Cmoch, P.; Luboradzki, R.
    Academic press:
    J. Org. Chem. (rok: 2021, tom: 86, strony: 7636-7647), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.joc.1c00697 - link to the publication
  3. Effect of modification of betulinic acid at the C3-carbon atom on the cytotoxicity of homolupane triterpenoids
    Authors:
    Lucie Rárová, Zbigniew Pakulski, Miroslav Strnad, Marie Kvasnicová, Tereza Štenclová, Piotr Cmoch
    Academic press:
    J. Med. Chem. (rok: 2021, tom: -, strony: -), Wydawca: AMER CHEMICAL SOC
    Status:
    Submitted
    DOI:
    Manuscript - link to the publication
  4. New lupane bidesmosides exhibiting strong cytotoxic activities in vitro
    Authors:
    Korda, A.; Rárová, L.; Pakulski, Z.; Strnad, M.; Okleš ková, J.; Kuczynska, K.; Cmoch, P.; Gwardiak, K.; Karczewski, R.
    Academic press:
    Bioorg. Chem. (rok: 2020, tom: 100, strony: 103868), Wydawca: ACADEMIC PRESS INC ELSEVIER SCIENCE
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103868 - link to the publication
  5. Synthesis and cytotoxic activity of 1,2,3-triazoles derived from 2,3-seco-dihydrobetulin via a click chemistry approach
    Authors:
    Kuczynska, K.; Bończak, B.; Rárová, L.; Kvasnicová, M.; Strnad, M.; Pakulski, Z.; Cmoch, P.; Fiałkowski, M.
    Academic press:
    J. Mol. Struct. (rok: 2022, tom: 1250, strony: 131751), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2021.131751 - link to the publication
  6. Synthesis of bidesmosidic lupane saponins – comparison of batch and continuous-flow methodologies
    Authors:
    Korda, A.; Pakulski, Z.; Cmoch, P.; Gwardiak, K.; Karczewski, R.
    Academic press:
    Carbohydr. Res. (rok: 2018, tom: 461, strony: 32-37), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.carres.2018.03.006 - link to the publication
  1. Recent progress in the glycosylation of lupanes
    Authors:
    Pakulski, Z.
    Book:
    Carbohydrate Chemistry: Chemical and Biological Approaches (rok: 2021, tom: 45, strony: 57-108), Wydawca: The Royal Society of Chemistry
    Status:
    Published

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