Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Examination of the relations between the HSPA2 chaperone protein and the proteins encoded by normal or mutated TP53 gene in non-small cell lung carcinoma.

2016/21/N/NZ5/01917

Keywords:

p53 p53 mutants molecular chaperones HSPA2 non-small cell lung carcinoma

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_14: Other related subjects
  • NZ5_1: Etiology of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Damian Sojka 

Number of co-investigators in the project: 3

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2017-02-21

Project end date (Y-m-d): 2022-02-20

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. Various Anti-HSPA2 Antibodies Yield Different Results in Studies on Cancer-Related Functions of Heat Shock Protein A2
    Authors:
    Dorota Scieglinska, Damian Robert Sojka, Agnieszka Gogler-Pigłowska, Vira Chumak, Zdzisław Krawczyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21124296 - link to the publication
  2. Functional redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma (NSCLC); an implication for NSCLC treatment
    Authors:
    Damian Robert Sojka, Agnieszka Gogler-Pigłowska, Natalia Vydra, Alexander Jorge Cortez, Piotr Teodor Filipczak, Zdzisław Krawczyk, Dorota Scieglinska
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 45306), Wydawca: Springer Nature Publishing AG
    Status:
    Published
    DOI:
    10.1038/s41598-019-50840-7 - link to the publication
  3. Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A
    Authors:
    Damian Robert Sojka, Sylwia Hasterok, Natalia Vydra, Agnieszka Toma‐Jonik, Anna Wieczorek, Agnieszka Gogler‐Pigłowska, Dorota Scieglinska
    Academic press:
    Cells (rok: 2021, tom: 10, 1418, strony: 2021, 10, 1418), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061418 - link to the publication
  1. p53-depletion enhances colon cancer cells' resistance to manumycin A
    Authors:
    Sojka DR, Rusin M, Zając G, Klyszcz K, Scieglinska D
    Conference:
    XXV Gliwice Scientific Meetings (rok: 2021, ), Wydawca: STOWARZYSZENIE NA RZECZ WSPIERANIA BADAŃ NAD RAKIEM
    Data:
    konferencja 18-20.11.2021
    Status:
    Published
  2. Analiza wpływu inhibicji proteasomu na ekspresję i agregację białek HSPA2 oraz p53
    Authors:
    Damian Sojka , Wojciech Pigłowski , Agnieszka Gogler-Pigłowska , Zdzisław Krawczyk , Krystyna Klyszcz , Dorota Ścieglińska
    Conference:
    V Śląskie Spotkania Naukowe (rok: 2018, ), Wydawca: STOWARZYSZENIE NA RZECZ WSPIERANIA BADAŃ NAD RAKIEM
    Data:
    konferencja 25-26.05.2018
    Status:
    Published
  3. THE HSPA PROTEIN FAMILY ARE INVOLVED IN PROTECTION AGAINST MANUMYCIN A TREATMENT IN NON SMALL CELL LUNG CARCINOMA (NSCLC)
    Authors:
    Damian Sojka , Sylwia Hasterok, Agnieszka Gogler-Pigłowska , Anna Wieczorek , Krystyna Klyszcz , Dorota Ścieglińska
    Conference:
    XXII Gliwice Scientific Meetings (rok: 2018, ), Wydawca: STOWARZYSZENIE NA RZECZ WSPIERANIA BADAŃ NAD RAKIEM
    Data:
    konferencja 16-17.11.2018
    Status:
    Published
  4. The functional comparison of HSPA1 and HSPA2 impact on growth and chemoresistance of nonsmall cell lung carcinoma cells (NSCLC)
    Authors:
    D.R. Sojka, A. GoglerPigłowska, N. Vydra, A.J. Cortez, Z. Krawczyk, D. Scieglinska
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: WILEY
    Data:
    konferencja 6-11.07.2019
    Status:
    Published
    DOI:
    link to the publication

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