Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Block polyelectrolytes controlling blood coagulation - synthesis, physicochemical and biological studies

2016/21/B/ST5/00837

Keywords:

heparins fondaparinux block polymers anticoagulation blood clotting

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_15:
  • ST5_21:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Szczubiałka 

Number of co-investigators in the project: 9

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 240 000 PLN

Project start date (Y-m-d): 2017-03-16

Project end date (Y-m-d): 2022-03-15

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik mikropłytek (110 000 PLN)
  2. Laptop do obsługi Turbiscana.
  3. Turbiscan (126 000 PLN)
  4. Urządzenie wielofunkcyjne: drukarka+skaner (1 548 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (5)
  1. Monitoring of anticoagulant activity of dabigatran and rivaroxaban in the presence of heparins
    Authors:
    Aleksandra Jakimczuk, Bartłomiej Kałaska, Kamil Kamiński, Joanna Mikłosz, Shin-Ichi Yusa, Dariusz Pawlak, Krzysztof Szczubiałka and Andrzej Mogielnicki
    Academic press:
    Journal of Clinical Medicine (rok: 2022, tom: 11, strony: 2236-2246), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm11082236 - link to the publication
  2. Anticoagulant properties of poly(sodium 2-(acrylamido)-2-methylpropanesulfonate)-based di- and triblock polymers
    Authors:
    Bartlomiej Kalaska, Kamiński Kamil, Joanna Miklosz, Keita Nakai, Shin-Ichi Yusa, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki, Krzysztof Szczubiałka
    Academic press:
    Biomacromolecules (rok: 2018, tom: 19, strony: 3104-3118), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.biomac.8b00691 - link to the publication
  3. Heparin-Binding Copolymer as a Complete Antidote for Low-Molecular-Weight Heparins in Rats
    Authors:
    Bartłomiej Kałaska*, Joanna Mikłosz, Kamil Kamiński, Justyna Świętoń, Aleksandra Jakimczuk, Shin-Ichi Yusa, Dariusz Pawlak, Maria Nowakowska, Krzysztof Szczubiałka*, Andrzej Mogielnicki
    Academic press:
    Journal of Pharmacology and Experimental Therapeutics (rok: 2020, tom: 373, strony: 51-61), Wydawca: American Society for Pharmacology and Experimental Therapeutics
    Status:
    Published
    DOI:
    10.1124/jpet.119.262931 - link to the publication
  4. Pharmacogenetic considerations of anticoagulant medication
    Authors:
    Joanna Miklosz, Bartlomiej Kalaska, Andrzej Mogielnicki
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2018, tom: 69, strony: 45305), Wydawca: Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2018.4.01 - link to the publication
  5. Reversal Activity and Toxicity of Heparin-Binding Copolymer after Subcutaneous Administration of Enoxaparin in Mice
    Authors:
    Justyna Świętoń, Joanna Mikłosz, Shin-Ichi Yusa, Krzysztof Szczubiałka, Dariusz Pawlak, Andrzej Mogielnicki, Bartłomiej Kałaska*
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11149), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms222011149 - link to the publication
  6. The neutralization of heparan sulfate by heparin binding copolymer as a potential therapeutic target
    Authors:
    Bartlomiej Kalaska, Joanna Miklosz, Kamil Kamiński, Bogdan Musielak, Shin-Ichi Yusa, Dariusz Pawlak, Maria Nowakowska, Krzysztof Szczubiałka, Andrzej Mogielnicki
    Academic press:
    RSC Advances (rok: 2019, tom: 9, strony: 3020-3029), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8ra09724k - link to the publication
  1. Heparin-binding copolymer as a universal antidote for low-molecular-weight heparins in rats
    Authors:
    Kałaska Bartłomiej, Mikłosz Joanna, Kamiński K., Swieton J., Jakimczuk Aleksandra, Yusa S.-I., Pawlak Dariusz, Nowakowska M., Szczubiałka K., Mogielnicki Andrzej
    Conference:
    The 27th Congress of the International Society of Thrombosis and Haemostasis (ISTH) (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 43652
    Status:
    Published
  2. Polymeric anticoagulants based on poly(2-(acrylamido)-2-methylpropanesulfonic acid) block polymers
    Authors:
    Krzysztof Szczubiałka, Bartlomiej Kalaska, Kamiński Kamil, Joanna Miklosz, Shin-Ichi Yusa, Emilia Sokołowska, Agnieszka Błażejczyk, Joanna Wietrzyk, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    26th Conference Biomaterials in Medicine and Veterinary Medicine, Rytro, Poland (rok: 2017, ), Wydawca: Engineering of Biomaterials, Wydawnictwo Naukowe Akapit
    Data:
    konferencja 12-15 October 2017
    Status:
    Published
  3. Heparin binding copolymer reverses the anticoagulant activity of low molecular weight heparins: safety and efficacy data in rats
    Authors:
    Joanna Miklosz, Bartlomiej Kalaska, Kamiński Kamil, Krzysztof Szczubiałka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    Frontiers in CardioVascular Biology, Fifth Congress of the European Society of Cardiology Council on Basic Cardiovascular Science (rok: 2018, ), Wydawca: Oxford University Press
    Data:
    konferencja 20-22 April, 2018
    Status:
    Published
  4. New parenteral poly(2-(acrylamide)-2-methylpropanesulfonic acid)-based anticoagulants (NPACs): efficacy and safety studies in rats
    Authors:
    Bartłomiej Kałaska, Kamil Kamiński, Joanna Mikłosz, Shin-Ichi Yusa, Keita Nakai, Krzysztof Szczubiałka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
    Conference:
    International Society on Thrombosis and Haemostasis (rok: 2017, ), Wydawca: Wiley
    Data:
    konferencja 8-13 lipca 2017
    Status:
    Published
  5. The therapeutic potential of heparin-binding copolymer as an inhibitor of heparan sulfate
    Authors:
    Mogielnicki Andrzej, Kałaska Bartłomiej, Mikłosz Joanna, Kamiński K., Yusa S.-I., Pawlak Dariusz, Nowakowska M., Szczubiałka K.
    Conference:
    The 27th Congress of the International Society of Thrombosis and Haemostasis (ISTH) (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 43652
    Status:
    Published

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