Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of protein factors that bind to the 5' non-coding region of human p53 mRNA in regulation of p53 expression at the translational level

2016/21/B/NZ1/02832

Keywords:

p53 mRNA protein isoforms non-coding region translation regulation of expression RNA-protein complexes

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Ciesiołka 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 092 000 PLN

Project start date (Y-m-d): 2017-02-16

Project end date (Y-m-d): 2021-08-15

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do elektroforezy żelowej (7 000 PLN)
  2. Zamrażarka niskotemperaturowa -80 st. C (67 000 PLN)
  3. Ekran z kasetą (35 000 PLN)
  4. Komputer z drukarką (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  1. Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 50-Terminal Region of p53 mRNA
    Authors:
    Damian M. Janecki, Agata Swiatkowska, Joanna Szpotkowska, Anna Urbanowicz, Martyna Kabacińska, Kamil Szpotkowski, Jerzy Ciesiołka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(24), strony: 13306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222413306 - link to the publication
  2. Translation of human Δ133p53 mRNA and its targeting by antisense oligonucleotides complementary to the 5'-terminal region of this mRNA.
    Authors:
    Żydowicz-Machtel P, Dutkiewicz M, Swiatkowska A, Gurda-Woźna D, Ciesiołka J.
    Academic press:
    PLoS One (rok: 2021, tom: 16(9), strony: e0256938), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0256938 - link to the publication
  3. Length and secondary structure of the 5′ non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies
    Authors:
    Joanna Szpotkowska, Agata Swiatkowska & Jerzy Ciesiołka
    Academic press:
    RNA Biology (rok: 2019, tom: 16(1), strony: 25-41), Wydawca: Taylor & Francis, Informa UK Limited, 5 Howick Place, London, SW1P 1WG
    Status:
    Published
    DOI:
    10.1080/15476286.2018.1556084 - link to the publication
  4. Regulation of the p53 expression profile by hnRNP K under stress conditions.
    Authors:
    Agata Swiatkowska, Mariola Dutkiewicz, Piotr Machtel, Damian M. Janecki, Martyna Kabacinska, Paulina Żydowicz-Machtel, Jerzy Ciesiołka
    Academic press:
    RNA Biology (rok: 2020, tom: 17, strony: 1402-1415), Wydawca: Taylor & Francis, Informa UK Limited, 5 Howick Place, London, SW1P 1WG
    Status:
    Published
    DOI:
    10.1080/15476286.2020.1771944 - link to the publication
  5. Structural Characteristics of the 5'-Terminal Region of Mouse p53 mRNA and Identification of Proteins That Bind to This mRNA Region
    Authors:
    Szpotkowska, J., Szpotkowski, K., Ciesiołka, J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 9709), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23179709 - link to the publication
  6. Translational Control in p53 Expression: The Role of 5'-Terminal Region of p53 mRNA
    Authors:
    Agata Świątkowska, Mariola Dutkiewicz, Paulina Żydowicz-Machtel, Joanna Szpotkowska, Damian M. Janecki, Jerzy Ciesiołka
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 5382), Wydawca: MDPI - Multidisciplinary Digital Publishing Institute, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms20215382 - link to the publication
  1. Structure and interactions of the 5′-terminal region of p53 mRNA which encodes Δ133p53 and Δ160p53 isoforms
    Authors:
    Paulina Żydowicz-Machtel, Mariola Dutkiewicz, Agata Świątkowska, Jerzy Ciesiołka
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: Polish Biochemical Society
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  2. Regulation of the p53 expression profile by hnRNP K under stress conditions
    Authors:
    Agata Świątkowska, Mariola Dutkiewicz, Piotr Machtel, Martyna Kabacińska, Paulina Żydowicz-Machtel, Jerzy Ciesiołka
    Conference:
    RNA 2019, The 24th Annual Meeting of the RNA Society, Kraków, Poland (rok: 2019, ), Wydawca: The RNA Society, Bethesda, Maryland, USA
    Data:
    konferencja 2019-06-11-16
    Status:
    Published

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