Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Synthesis and pharmacological characterization of structurally diverse chemical analogues of compound PO-10 as multiple ligands for potential cognition enhamencement in animal models of depression, anxiety and schizophrenia.

2016/21/D/NZ7/01573

Keywords:

of depression anxiety schizophrenia cognitive impairment

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_16:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Zagórska 

Number of co-investigators in the project: 8

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 637 790 PLN

Project start date (Y-m-d): 2017-01-23

Project end date (Y-m-d): 2021-01-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wyparka rotacyjnaz pompa próżniową, łaźnią i termostatem cyrkulacyjnym (chiller) (42 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (3)
  1. Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl- piperazinyl- alkyl derivatives of 1H-imidazo[ 2,1-f] purine-2,4( 3H,8H)-dione with antidepressant-and anxiolytic-like activities
    Authors:
    Agnieszka Zagórska, Anna Partyka, Adam Bucki, Marcin Kołaczkowski, Magdalena Jastrzębska-Więsek, Anna Czopek, Agata Siwek, Monika Głuch-Lutwin, Marek Bednarski, Marek Bajda, Jakub Jończyk, Kamil Piska, Paulina Koczurkiewicz, Anna Wesołowska, Maciej Pawłowski
    Academic press:
    Chemical Biology & Drug Design (rok: 2018, tom: 45609, strony: 45313), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1111/cbdd.13442. - link to the publication
  2. Design, synthesis, and behavioral evaluation of dual-actingcompounds as phosphodiesterase type 10A (PDE10A) inhibitors andserotonin ligands targeting neuropsychiatric symptoms in dementia
    Authors:
    Agnieszka Zagórska, Adam Bucki, Anna Partyka, Magdalena Jastrzębska-Więsek, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Anna Jaromin, Maria Walczak, Anna Wesołowska, Marcin Kołaczkowski
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2022, tom: 233, strony: 114218), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2022.114218 - link to the publication
  3. The Antidepressant-like Activity, Effects on RecognitionMemory Deficits, Bioavailability, and Safety after ChronicAdministration of New Dual-Acting Small CompoundsTargeting Neuropsychiatric Symptoms in Dementia
    Authors:
    Magdalena Jastrzębska-Więsek, Magdalena Kotańska, Aleksandra Grzeszczak, Anna Jaromin, Maria Walczak, Anna Partyka, Joanna Gdula-Argasińska, Magdalena Smolik ,Agnieszka Zagórska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 11452), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231911452 - link to the publication
  4. Phosphodiesterase 10 (PDE10) inhibitors: an updated patent review (2014-present)
    Authors:
    Agnieszka Zagórska
    Academic press:
    Expert Opinion On Therapeutic Patents (rok: 2020, tom: 30, strony: 147-157), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/13543776.2020.1709444 - link to the publication
  5. Phosphodiesterase 10 Inhibitors – Novel Perspectives for Psychiatric and Neurodegenerative Drug Discovery
    Authors:
    Agnieszka Zagórska, Anna Partyka, Adam Bucki, Alicja Gawalska, Anna Czopek, Maciej Pawłowski
    Academic press:
    Current Medicinal Chemistry (rok: 2018, tom: 25, strony: 3455-3481), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867325666180309110629 - link to the publication
  1. PHARMACOKINETIC PROFILE OF NEW DUAL-ACTING COMPOUNDS - SEROTONIN RECEPTOR LIGANDS AND PHOSPHODIESTERASE 10A INHIBITORS
    Authors:
    Agnieszka ZAGÓRSKA, Paulina JANISZEWSKA, Anna PARTYKA, Maria WALCZAK
    Conference:
    XI Multidyscyplinarna Konferencja Nauki o Leku (rok: 2018, ), Wydawca: INSTYTUT FARMACEUTYCZNY
    Data:
    konferencja 14 – 16 LISTOPADA
    Status:
    Published
  2. Physicochemical and Pharmacokinetic Properties of New Dual-Acting Compounds for the Treatment of Mental Disorders
    Authors:
    Agnieszka Zagórska , Paweł Żmudzki , Paulina Janiszewska, Maria Walczak
    Conference:
    2nd Molecules Medicinal Chemistry Symposium (rok: 2019, ), Wydawca: MDPI
    Data:
    konferencja 15-17 maja
    Status:
    Published
  3. SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF STRUCTURALLY DIVERSE CHEMICAL ANALOQUES OF COMPOUND PQ-10
    Authors:
    Agnieszka Zagórska, Anna Partyka, Adam Bucki, Grażyna Chłoń-Rzepa, Magdalena Jastrzębska-Więsek, Agata Siwek, Monika Głuch-Lutwin, Maciej Pawłowski
    Conference:
    Hellenic Symposium on Medicinal Chemistry (rok: 2017, ), Wydawca: EFMC
    Data:
    konferencja 1-3, czerwca
    Status:
    Published

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